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International Journal of Molecular Sciences, Volume 20, Issue 9

May-1 2019 - 316 articles

Cover Story: Seed storage proteins must be hydrolyzed by proteases to facilitate the delivery of amino acids essential for embryo growth and development. This review focuses on the current implications of proteases in the germination of two cereal species, barley and wheat, for which the establishment of processes of proteolytic control during the germination process has considerable economic value. Emphasis is placed on recent attempts to increase our understanding the proteases involved in barley and wheat seed germination by means of novel genomic and proteomic technologies. View this paper
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Articles (316)

  • Article
  • Open Access
17 Citations
5,049 Views
16 Pages

Due to the inevitable presence of random defects, unpredictable grain boundaries in macroscopic samples, stress concentration at clamping points, and unknown load distribution in the investigation of graphene sheets, uncertainties are crucial and cha...

  • Article
  • Open Access
21 Citations
5,149 Views
24 Pages

Transcriptomic Analysis Reveals a Comprehensive Calcium- and Phytohormone-Dominated Signaling Response in Leymus chinensis Self-Incompatibility

  • Shuangyan Chen,
  • Junting Jia,
  • Liqin Cheng,
  • Pincang Zhao,
  • Dongmei Qi,
  • Weiguang Yang,
  • Hui Liu,
  • Xiaobing Dong,
  • Xiaoxia Li and
  • Gongshe Liu

Sheepgrass (Leymus chinensis (Trin.) Tzvel.) is an economically and ecologically important forage in the grass family. Self-incompatibility (SI) limits its seed production due to the low seed-setting rate after self-pollination. However, investigatio...

  • Review
  • Open Access
11 Citations
8,223 Views
11 Pages

Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development

  • Eunmi Lee,
  • Raziye Piranlioglu,
  • Max S. Wicha and
  • Hasan Korkaya

It is now widely believed that mammary epithelial cell plasticity, an important physiological process during the stages of mammary gland development, is exploited by the malignant cells for their successful disease progression. Normal mammary epithel...

  • Review
  • Open Access
1,243 Citations
56,859 Views
23 Pages

Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications

  • Michele Longo,
  • Federica Zatterale,
  • Jamal Naderi,
  • Luca Parrillo,
  • Pietro Formisano,
  • Gregory Alexander Raciti,
  • Francesco Beguinot and
  • Claudia Miele

Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating systemic energy homeostasis. Adipose tissue expands by a combination o...

  • Article
  • Open Access
13 Citations
5,149 Views
15 Pages

A Natural mtDNA Polymorphism in Complex III Is a Modifier of Healthspan in Mice

  • Misa Hirose,
  • Axel Künstner,
  • Paul Schilf,
  • Anna Katharina Tietjen,
  • Olaf Jöhren,
  • Patricia Huebbe,
  • Gerald Rimbach,
  • Jan Rupp,
  • Markus Schwaninger and
  • Hauke Busch
  • + 1 author

In this study, we provide experimental evidence that a maternally inherited polymorphism in the mitochondrial cytochrome b gene (mt-Cytb; m.15124A>G, Ile-Val) in mitochondrial complex III resulted in middle-aged obesity and higher susceptibility t...

  • Article
  • Open Access
33 Citations
7,833 Views
27 Pages

Rice (Oryza sativa L.) is one of the most important food crops in the world. In plants, jasmonic acid (JA) plays essential roles in response to biotic and abiotic stresses. As one of the largest transcription factors (TFs), basic region/leucine zippe...

  • Article
  • Open Access
4 Citations
4,204 Views
11 Pages

Bombyx mori doublesex (Bmdsx) functions as a double-switch gene in the final step of the sex-determination cascade in the silkworm Bombyx mori. The P-element somatic inhibitor (PSI) protein in B. mori interacts with Bmdsx pre-mRNA in CE1 as an exonic...

  • Review
  • Open Access
7 Citations
3,882 Views
6 Pages

PD-L1 Expression in Mastocytosis

  • Margaret Williams,
  • Diane S. Lidke,
  • Karin Hartmann and
  • Tracy I. George

Programmed death 1 (PD-1), when activated by its ligands PD-L1 and PD-L2, suppresses active immune cells in normal immune regulation to limit autoimmunity and, in tumors, as a mechanism of immune evasion. PD-L1 expression has been described as both a...

  • Review
  • Open Access
24 Citations
8,031 Views
56 Pages

A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies

  • Sara Hegazi,
  • Christopher Lowden,
  • Julian Rios Garcia,
  • Arthur H. Cheng,
  • Karl Obrietan,
  • Joel D. Levine and
  • Hai-Ying Mary Cheng

The central pacemakers of circadian timekeeping systems are highly robust yet adaptable, providing the temporal coordination of rhythms in behavior and physiological processes in accordance with the demands imposed by environmental cycles. These feat...

  • Review
  • Open Access
15 Citations
6,941 Views
28 Pages

Calcium-binding proteins (CBPs) can influence and react to Ca2+ transients and modulate the activity of proteins involved in both maintaining homeostatic conditions and protecting cells in harsh environmental conditions. Hibernation is a strategy tha...

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Int. J. Mol. Sci. - ISSN 1422-0067