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PD-L1 Expression in Mastocytosis

1
Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
2
ARUP Laboratories, Salt Lake City, UT 84108, USA
3
Department of Pathology and Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87102, USA
4
Division of Allergy, Department of Dermatology, University of Basel, 4031 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2362; https://doi.org/10.3390/ijms20092362
Received: 8 April 2019 / Revised: 1 May 2019 / Accepted: 4 May 2019 / Published: 13 May 2019
(This article belongs to the Special Issue Mast Cells in Health and Disease)
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Abstract

Programmed death 1 (PD-1), when activated by its ligands PD-L1 and PD-L2, suppresses active immune cells in normal immune regulation to limit autoimmunity and, in tumors, as a mechanism of immune evasion. PD-L1 expression has been described as both a prognostic and predictive marker in many solid and hematologic neoplasms, as targeted therapies against the PD-1/PD-L1 interaction have gained clinical importance. PD-L1 expression has been assessed in a few studies on mastocytosis. We review this literature and the need for further investigation of the tumor-immune interaction in mastocytosis. View Full-Text
Keywords: immune checkpoint; PD-1; PD-L1; mastocytosis immune checkpoint; PD-1; PD-L1; mastocytosis
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Williams, M.; Lidke, D.S.; Hartmann, K.; George, T.I. PD-L1 Expression in Mastocytosis. Int. J. Mol. Sci. 2019, 20, 2362.

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