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PD-L1 Expression in Mastocytosis

Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
ARUP Laboratories, Salt Lake City, UT 84108, USA
Department of Pathology and Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87102, USA
Division of Allergy, Department of Dermatology, University of Basel, 4031 Basel, Switzerland
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2362;
Received: 8 April 2019 / Revised: 1 May 2019 / Accepted: 4 May 2019 / Published: 13 May 2019
(This article belongs to the Special Issue Mast Cells in Health and Disease)
PDF [2428 KB, uploaded 13 May 2019]


Programmed death 1 (PD-1), when activated by its ligands PD-L1 and PD-L2, suppresses active immune cells in normal immune regulation to limit autoimmunity and, in tumors, as a mechanism of immune evasion. PD-L1 expression has been described as both a prognostic and predictive marker in many solid and hematologic neoplasms, as targeted therapies against the PD-1/PD-L1 interaction have gained clinical importance. PD-L1 expression has been assessed in a few studies on mastocytosis. We review this literature and the need for further investigation of the tumor-immune interaction in mastocytosis. View Full-Text
Keywords: immune checkpoint; PD-1; PD-L1; mastocytosis immune checkpoint; PD-1; PD-L1; mastocytosis

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Williams, M.; Lidke, D.S.; Hartmann, K.; George, T.I. PD-L1 Expression in Mastocytosis. Int. J. Mol. Sci. 2019, 20, 2362.

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