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Molecules, Volume 24, Issue 23

December-1 2019 - 221 articles

Cover Story: Dipyrromethanes constitute a widely known and relevant class of useful synthetic building blocks in the chemistry of several high-value pyrrolic macrocycles, e.g. calixpyrroles, porphyrins, chlorins, corroles, saphyrins, and dipyrromethene compounds, such as boron dipyrrins (BODIPYs) and various related transition metal coordination complexes. A bibliographic review on the synthesis of dipyrromethane scaffolds surveying the past six years (2014-2019) is herein provided. Classic synthetic approaches employing the acid-catalyzed condensation of pyrroles and aldehydes or ketones, as well as modern strategies that allow the synthesis of original dipyrromethane structures with novel substitution patterns are presented. View this paper.
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Articles (221)

  • Article
  • Open Access
22 Citations
4,126 Views
13 Pages

3 December 2019

Salvianolic acid B is one of the main water-soluble components of Salvia miltiorrhiza Bge. Many reports have shown that it has significant anti-myocardial ischemia effect. However, the underlying mechanism remains unclear. Our present study demonstra...

  • Article
  • Open Access
12 Citations
5,755 Views
25 Pages

3 December 2019

The downscaling of NMR tensorial interactions, such as dipolar couplings, from tens of kilohertz to a few hertz in low-order media is the result of dynamics spanning several orders of magnitudes, including vibrational modes (~ns-fs), whole-molecule r...

  • Communication
  • Open Access
12 Citations
5,168 Views
12 Pages

3 December 2019

Carpesium divaricatum Sieb. and Zucc. has long been used both as traditional medicine and seasonal food. The most extensively studied specialized metabolites synthesized by the plant are sesquiterpene lactones of germacrane-type. Low-molecular and vo...

  • Review
  • Open Access
69 Citations
12,407 Views
31 Pages

3 December 2019

Annona species have been a valuable source of anti-infective and anticancer agents. However, only limited evaluations of their alkaloids have been carried out. This review collates and evaluates the biological data from extracts and purified isolates...

  • Article
  • Open Access
18 Citations
6,587 Views
32 Pages

Optimizing Water-Based Extraction of Bioactive Principles of Hawthorn: From Experimental Laboratory Research to Homemade Preparations

  • Phu Cao Ngoc,
  • Laurent Leclercq,
  • Jean-Christophe Rossi,
  • Isabelle Desvignes,
  • Jasmine Hertzog,
  • Anne-Sylvie Fabiano-Tixier,
  • Farid Chemat,
  • Philippe Schmitt-Kopplin and
  • Hervé Cottet

3 December 2019

Hawthorn (Crataegus) is used for its cardiotonic, hypotensive, vasodilative, sedative, antiatherosclerotic, and antihyperlipidemic properties. One of the main goals of this work was to find a well-defined optimized extraction protocol usable by each...

  • Article
  • Open Access
5 Citations
3,402 Views
13 Pages

2 December 2019

The aim of the present study was to establish a standard methodology for the extraction of epoxy resin precursors from several types of food packages (cans, multi-layered composite material, and cups) with selected simulation media (distilled water,...

  • Article
  • Open Access
49 Citations
6,852 Views
15 Pages

Poly(Dopamine) Coating on 3D-Printed Poly-Lactic-Co-Glycolic Acid/β-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering

  • Zhimin Xu,
  • Ningning Wang,
  • Peng Liu,
  • Yidan Sun,
  • Yumeng Wang,
  • Fan Fei,
  • Shichen Zhang,
  • Jianying Zheng and
  • Bing Han

2 December 2019

Bone defects caused by osteoporosis, bone malignant tumors, and trauma are very common, but there are many limiting factors in the clinical treatment of them. Bone tissue engineering is the most promising treatment and is considered to be the main st...

  • Article
  • Open Access
14 Citations
4,870 Views
18 Pages

2-Unsubstituted Imidazole N-Oxides as Novel Precursors of Chiral 3-Alkoxyimidazol-2-ylidenes Derived from trans-1,2-Diaminocyclohexane and Other Chiral Amino Compounds

  • Grzegorz Mlostoń,
  • Małgorzata Celeda,
  • Marcin Jasiński,
  • Katarzyna Urbaniak,
  • Przemysław J. Boratyński,
  • Peter R. Schreiner and
  • Heinz Heimgartner

2 December 2019

‘Desymmetrization’ of trans-1,2-diaminocyclohexane by treatment with α,ω-dihalogenated alkylation reagents leads to mono-NH2 derivatives (‘primary-tertiary diamines’). Upon reaction with formaldehyde, these product...

  • Article
  • Open Access
14 Citations
3,768 Views
15 Pages

Relativistic Effects on NMR Parameters of Halogen-Bonded Complexes

  • Ibon Alkorta,
  • José Elguero,
  • Manuel Yáñez,
  • Otilia Mó and
  • M. Merced Montero-Campillo

2 December 2019

Relativistic effects are found to be important for the estimation of NMR parameters in halogen-bonded complexes, mainly when they involve the heavier elements, iodine and astatine. A detailed study of 60 binary complexes formed between dihalogen mole...

  • Article
  • Open Access
25 Citations
3,681 Views
14 Pages

Simultaneous Use of Stimulatory Agents to Enhance the Production and Hypoglycaemic Activity of Polysaccharides from Inonotus obliquus by Submerged Fermentation

  • Mengya Wang,
  • Zhezhen Zhao,
  • Xia Zhou,
  • Jinrong Hu,
  • Jiao Xue,
  • Xiao Liu,
  • Jingsheng Zhang,
  • Ping Liu and
  • Shisheng Tong

2 December 2019

This study aimed to determine the effect of applying stimulatory agents to liquid cultured Inonotus obliquus on the simultaneous accumulation of exo-polysaccharides (EPS) and their monosaccharide composition. Different stimulatory agents (VB6, VB1, b...

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Molecules - ISSN 1420-3049