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Molecules, Volume 24, Issue 19 (October-1 2019)
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Cover Story (view full-size image) RNAs are receiving increasing recognition for their new roles in biology, or as new drug targets [...] Read more. RNAs are receiving increasing recognition for their new roles in biology, or as new drug targets and nanomaterials. Yet, their biophysical characterization continues to lag behind those of proteins. In particular, NMR spectroscopy remains a versatile tool for probing RNA structure and dynamics. Yet, NMR suffers from chemical shift overlap and line broadening, both of which become worse in large RNAs. Incorporating stable isotope labels into RNA—especially via solid-phase chemical synthesis using phosphoramidites—completely circumvents the spectral overlap problem. Here, we highlight the practical aspects of this methodology for RNA analysis, and showcase how labeled phosphoramidites enable collaborative efforts toward tackling integrative structural dynamics problems in RNA biology. View this paper.