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Antidiabetic and Cosmeceutical Potential of Common Barbery (Berberis vulgaris L.) Root Bark Extracts Obtained by Optimization of ‘Green’ Ultrasound-Assisted Extraction

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Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Marulićev trg 20, 10 000 Zagreb, Croatia
2
Department of Food Chemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb, Domagojeva 1, 10 000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Academic Editor: Gregory Chatel
Molecules 2019, 24(19), 3613; https://doi.org/10.3390/molecules24193613
Received: 1 August 2019 / Revised: 24 August 2019 / Accepted: 28 August 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Sonochemistry and Green Chemistry Applications II)
Berberis vulgaris is rich in berberine, an isoquinoline alkaloid, with antidiabetic activity, often used topically for skin-related problems. The aim of this work was to develop a “green” method for berberine extraction using mixtures of water with glycerol, a non-toxic, environmentally-friendly solvent. Response surface methodology based on Box–Behnken design was used to optimize the experimental conditions for ultrasound-assisted extraction of berberine and anti-radical components from B. vulgaris root bark. The independent variables were temperature (X1), glycerol concentration (X2), and ultrasound power (X3), while the responses were berberine concentration and DPPH radical scavenging activity of the extracts (RSA IC50). The response values of the extracts prepared at optimum conditions were (response, X1, X2, X3): berberine yield (145.5 μg/mL; 80 °C, 50%, 144 W) and RSA IC50 (58.88 μL/mL; 80 °C, 30%, 720 W). The observed values deviated from the predicted values by −3.45% and 6.42% for berberine and RSA IC50, respectively, thus indicating the validity of the selected models. The prepared extracts demonstrated antioxidant, anti-melanogenic, and anti-inflammatory activity, as well excellent α-glucosidase and α-amylase inhibitory activity. The displayed biological properties and lack of glycerol toxicity makes the prepared extracts suitable for direct inclusion into antidiabetic and dermatologic food supplements and topical products. View Full-Text
Keywords: berberine; Berberis vulgaris; green extraction; glycerol; response surface methodology berberine; Berberis vulgaris; green extraction; glycerol; response surface methodology
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Dulić, M.; Ciganović, P.; Vujić, L.; Zovko Končić, M. Antidiabetic and Cosmeceutical Potential of Common Barbery (Berberis vulgaris L.) Root Bark Extracts Obtained by Optimization of ‘Green’ Ultrasound-Assisted Extraction. Molecules 2019, 24, 3613.

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