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Molecules, Volume 22, Issue 5

2017 May - 174 articles

Cover Story: The fluorescent chemical probe PDI-1 was designed for strong binding and quantification of glycosaminoglycans, a class of complex polysaccharides, by a simple mix-and-read assay. The interaction between probe and analyte leads to the formation of fluorescence-quenched aggregates. Performance of the probe in a competitive blood plasma matrix is exemplified by the detection of dermatan sulfate, a component of antithrombotic drugs. View the paper
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Articles (174)

  • Review
  • Open Access
104 Citations
16,394 Views
19 Pages

Antidiabetic Effects of Tea

  • Qiu-Yue Fu,
  • Qing-Sheng Li,
  • Xiao-Ming Lin,
  • Ru-Ying Qiao,
  • Rui Yang,
  • Xu-Min Li,
  • Zhan-Bo Dong,
  • Li-Ping Xiang,
  • Xin-Qiang Zheng and
  • Yue-Rong Liang
  • + 3 authors

Diabetes mellitus (DM) is a chronic endocrine disease resulted from insulin secretory defect or insulin resistance and it is a leading cause of death around the world. The care of DM patients consumes a huge budget due to the high frequency of consul...

  • Article
  • Open Access
10 Citations
6,427 Views
11 Pages

Microwave-Assisted Synthesis of Imidazo[4,5-f][1,10]phenanthroline Derivatives as Apoptosis Inducers in Chemotherapy by Stabilizing Bcl-2 G-quadruplex DNA

  • Li Li,
  • Jie-Qiong Cao,
  • Hui-Min Liu,
  • Qiong Wu,
  • Qiu-Hui Pan,
  • Zhi-Ping Zeng,
  • Yu-Tao Lan,
  • Yu-Mei Li,
  • Wen-Jie Mei and
  • Wen-Jie Zheng
  • + 1 author

Herein, a series of imidazo[4,5-f][1,10] phenanthroline derivatives RPIP (PIP = imidazo [4,5-f][1,10] phenanthroline, R = NO2, 1; CF3, 2; Cl, 3; OH, 4) have been synthesized in yields of 82.3–94.7% at 100 °C under the irradiation of microwave. MTT as...

  • Review
  • Open Access
116 Citations
11,329 Views
20 Pages

The Impact of Halloysite on the Thermo-Mechanical Properties of Polymer Composites

  • Tayser Sumer Gaaz,
  • Abu Bakar Sulong,
  • Abdul Amir H. Kadhum,
  • Ahmed A. Al-Amiery,
  • Mohamed H. Nassir and
  • Ahed Hameed Jaaz

Nanotubular clay minerals, composed of aluminosilicate naturally structured in layers known as halloysite nanotubes (HNTs), have a significant reinforcing impact on polymer matrixes. HNTs have broad applications in biomedical applications, the medici...

  • Article
  • Open Access
25 Citations
6,610 Views
15 Pages

Rapid and Cost-Effective Quantification of Glucosinolates and Total Phenolic Content in Rocket Leaves by Visible/Near-Infrared Spectroscopy

  • Eva María Toledo-Martín,
  • Rafael Font,
  • Sara Obregón-Cano,
  • Antonio De Haro-Bailón,
  • Myriam Villatoro-Pulido and
  • Mercedes Del Río-Celestino

The potential of visible-near infrared spectroscopy to predict glucosinolates and total phenolic content in rocket (Eruca vesicaria) leaves has been evaluated. Accessions of the E. vesicaria species were scanned by NIRS as ground leaf, and their refe...

  • Article
  • Open Access
15 Citations
6,189 Views
13 Pages

Two novel glucosylated zinc(ІІ) phthalocyanines 7a–7b, as well as the acetyl-protected counterparts 6a–6b, have been synthesized by the Cu(I)-catalyzed 1,3-dipolar cycloaddition between the propargylated phthalocyanine and azide-substituted glucoses....

  • Communication
  • Open Access
29 Citations
5,857 Views
9 Pages

Quantitative determination of multiple effective components in a given plant usually requires a very large amount of authentic natural products. In this study, we proposed a rapid and non-destructive method for the simultaneous determination of echin...

  • Review
  • Open Access
16 Citations
5,798 Views
14 Pages

The goal of combined pharmacological approaches in the treatment of the acute radiation syndrome (ARS) is to obtain an effective therapy producing a minimum of undesirable side effects. This review summarizes important data from studies evaluating th...

  • Article
  • Open Access
6 Citations
5,276 Views
8 Pages

Emulsion-Based Intradermal Delivery of Melittin in Rats

  • Sang Mi Han,
  • Se Gun Kim and
  • Sok Cheon Pak

Bee venom (BV) has long been used as a traditional medicine. The aim of the present study was to formulate a BV emulsion with good rheological properties for dermal application and investigate the effect of formulation on the permeation of melittin t...

  • Review
  • Open Access
88 Citations
10,062 Views
13 Pages

A suitable oxidative system is crucial to electrophilic selenium catalysis (ESC). This short review offers the overview of recent development in ESC with electrophilic N-F reagents as the oxidants. Several highly selective transformations of alkenes...

  • Article
  • Open Access
28 Citations
8,348 Views
8 Pages

Electrophilic Trifluoromethylselenolation of Boronic Acids

  • Clément Ghiazza,
  • Anis Tlili and
  • Thierry Billard

Trifluoromethylselenylated compounds are emergent compounds with interesting physicochemical properties that still suffer from a lack of efficient synthetic methods. We recently developed an efficient one-pot strategy to generate in situ CF3SeCl and...

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Molecules - ISSN 1420-3049