Non-Communicable Diseases Silent Killer: Metabolic and Obesity Risks of Sedentary Behaviors

Dear Colleagues,

Non-communicable diseases (NCDs) remain the leading cause of death worldwide, accounting for the majority of preventable morbidity and mortality. Among the most significant contributors are sedentary behaviors, which silently increase the risk of obesity, metabolic dysfunction, cardiovascular disease, and related health complications. As modern lifestyles become increasingly inactive, the need to better understand the biological, clinical, and societal impacts of sedentary behavior has never been more urgent. This Topic aims to shed light on these silent killers by bringing together innovative research, critical analyses, and practical solutions that can guide both clinical practice and public health policy. The fourth Ellisras Longitudinal Study and Other None-Communicable Diseases Studies International Conference dated 25 to 27 November 2025 at University of Limpopo and Radibaki Primary School, South Africa aim to combat thsese silent killer at community level. We warmly invite researchers to contribute original articles, reviews, and perspectives that deepen our understanding of sedentary behavior as a modifiable risk factor for NCDs. Original research and review papers with emphasis on, but not limited to, the following topics are welcome:

1. Metabolic and obesity-related risks associated with sedentary behavior in diverse populations.
2. Mechanistic insights, epidemiological trends, and intervention strategies targeting sedentary lifestyles.
3. Platform for cross-disciplinary collaboration between medicine, public health, behavioral science, and policy.
4. Evidence-based strategies to reduce the global burden of NCDs through prevention, early detection, and sustainable health promotion.
5. None communicable diseases  reproductive and environmetal health  risk factors

Prof. Dr. Kotsedi Daniel Monyeki
Dr. Machoene Derrick Sekgala
Topic Editors