Natural Compounds in Plants, 3rd Edition

Topic Information

Dear Colleagues,

Following the success of the 1st and 2nd editions of “Natural Compounds in Plants” and the substantial interest in this research topic, we are pleased to announce the launch of the 3rd edition. Higher plants have provided humankind with sources of medicine, cosmetics, fragrances and flavors since prehistoric times. For this Topic, we encourage the submission of research articles and timely reviews that attend to various aspects of phytochemistry, including, but not limited to, natural product drug discovery, the biological activities of phytochemicals, and the application of plant-derived natural products in agriculture, crop protection, and green pesticides.

Dr. Zdenek Wimmer
Dr. Michal Jurasek
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Analytica analytica	7.4	7.2	2020	19.4 Days	CHF 1200	Submit
Antioxidants antioxidants	8.2	14.7	2012	18.7 Days	CHF 2900	Submit
Crops crops	2.1	2.9	2021	20.7 Days	CHF 1200	Submit
Pharmaceuticals pharmaceuticals	5.7	9.0	2004	14.3 Days	CHF 2900	Submit
Plants plants	4.7	8.5	2012	14.8 Days	CHF 2700	Submit
Seeds seeds	3.0	4.0	2022	20.6 Days	CHF 1200	Submit

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Published Papers (2 papers)

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All Crops Pharmaceuticals Plants Antioxidants Seeds Analytica

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17 pages, 5371 KB  

Open AccessArticle

Extract of Origanum vulgare L.: Chemical Composition by HPLC-DAD, Antioxidant Activity, Biocompatibility, and Antifungal and Antibiofilm Action

by Geovani Moreira da Cruz, Raquel Teles de Menezes, Lara Steffany de Carvalho, Tuana Mendonça Faria Cintra, Gabriela Torres Tediole, Paula dos Santos Avelino, Maria Cristina Marcucci, Luciane Dias de Oliveira and Vanessa Marques Meccatti-Domiciano

Analytica 2026, 7(3), 46; https://doi.org/10.3390/analytica7030046 - 11 Jul 2026

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Abstract

Candida spp. can cause systemic infections with high mortality in immunocompromised patients. Phytotherapy may be an alternative for adjunctive treatment of fungal infections. This study evaluated the phytochemical profile, cytotoxicity, genotoxicity, and antibiofilm activity of the hydroalcoholic extract of Origanum vulgare L. against [...] Read more.

Candida spp. can cause systemic infections with high mortality in immunocompromised patients. Phytotherapy may be an alternative for adjunctive treatment of fungal infections. This study evaluated the phytochemical profile, cytotoxicity, genotoxicity, and antibiofilm activity of the hydroalcoholic extract of Origanum vulgare L. against Candida albicans, Candida tropicalis, and Candida dubliniensis. The extraction and quantification (flavonoids and phenols) were performed, and its antioxidant activity (DPPH) and the presence of bio-active compounds were investigated using high-performance liquid chromatography with Diode Array Detection (HPLC-DAD). Cytotoxicity and genotoxicity tests were conducted using HaCat cell lines. Antifungal activity on planktonic cultures was evaluated using the standard (CLSI M27-S4). The analysis of the extract on biofilms was verified with different exposure times. The extract demonstrated the presence of bioactive molecules, and antioxidant activity. The cytotoxicity test showed viability >70%. Genotoxicity revealed the presence of a few micronuclei in some dilutions. The Minimum Fungicidal Concentration was obtained for C. albicans and C. tropicalis. In the biofilm analysis, there was a reduction of more than 60% in all Candida spp. species at the 24 h exposure time. The findings suggest that the O. vulgare extract exhibits activity against Candida spp. and shows biocompatibility in human keratinocytes. Full article

(This article belongs to the Topic Natural Compounds in Plants, 3rd Edition)

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19 pages, 6762 KB  

Open AccessArticle

Kuwanon A from Morus alba L. Alleviates H₂O₂-Induced Oxidative Damage in HaCaT Keratinocytes by Inhibiting Ferroptosis and Enhancing Antioxidant Capacity

by Yan Liu, Hening Fu, Junjie Ma, Youqing Wang, Zhaohua Shi, Yupeng Liu, Xianju Huang, Bingchen Han and Jun Li

Antioxidants 2026, 15(6), 657; https://doi.org/10.3390/antiox15060657 - 22 May 2026

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Abstract

The root bark of Morus alba L. is commonly used as a natural antioxidant; however, its active constituents and underlying molecular mechanisms remain unclear. In this study, a bioactivity-guided isolation approach was employed to identify antioxidant substances from the root bark of Morus [...] Read more.

The root bark of Morus alba L. is commonly used as a natural antioxidant; however, its active constituents and underlying molecular mechanisms remain unclear. In this study, a bioactivity-guided isolation approach was employed to identify antioxidant substances from the root bark of Morus alba L. and to investigate their protective effects against oxidative damage in HaCaT cells. Using techniques such as silica gel column chromatography and semi-preparative HPLC, combined with NMR and HR-ESI-MS analysis, 22 compounds were isolated and identified from the dichloromethane extract of Morus alba L. root bark, including Diels–Alder adducts, flavonoids, and benzofurans. Among them, compounds 1 and 2 are new compounds, while compounds 12 and 16 were isolated from this plant for the first time. Bioactivity screening revealed that Kuwanon A (compound 17) exhibited significant cytoprotective effects in an H₂O₂-induced HaCaT cell injury model, effectively scavenging intracellular reactive oxygen species (ROS), restoring mitochondrial function, and enhancing the activities of antioxidant enzymes such as SOD and GSH. Further studies indicated that H₂O₂ induced ferroptosis in HaCaT cells, characterized by abnormal Fe²⁺ levels, lipid peroxidation, and elevated levels of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α). Kuwanon A significantly ameliorated these pathological changes. Consistently, ELISA and Astral DIA quantitative proteomics analyses demonstrated that Kuwanon A specifically upregulates the expression of the sulfurtransferase NFS1, thereby promoting the expression of the core antioxidant enzyme GPX4 and the iron storage protein ferritin-H, collectively inhibiting ferroptosis. This study elucidates that Kuwanon A is a key active component responsible for the antioxidant and anti-inflammatory effects of Morus alba L. root bark, and its mechanism is closely associated with regulating the NFS1-mediated ferroptosis defense pathway. Full article

(This article belongs to the Topic Natural Compounds in Plants, 3rd Edition)

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