Advanced Imaging, Physiology, and Biomarkers in Ischemic Heart Disease

Dear Colleagues,

Ischemic heart disease (IHD) continues to represent a major global health burden despite significant advances in revascularization techniques and pharmacotherapy. The integration of advanced cardiac imaging, coronary physiology, and biomarker assessment offers new opportunities to refine diagnosis, risk stratification, and therapeutic decision-making. This Topic, entitled “Advanced Imaging, Physiology, and Biomarkers in Ischemic Heart Disease”, aims to highlight contemporary developments and emerging evidence in these interrelated domains.

We welcome submissions that address novel applications of non-invasive and invasive imaging modalities (including CT, MRI, echocardiography, and intravascular imaging) for characterizing coronary anatomy, plaque vulnerability, myocardial perfusion, and viability. Studies exploring physiological assessment tools such as FFR, iFR, and novel computational indices, as well as investigations of circulating or tissue biomarkers reflecting ischemia, inflammation, or myocardial recovery, are particularly encouraged.

By integrating insights across imaging, physiology, and molecular biology, this Topic seeks to advance a mechanistic understanding of IHD and promote precision cardiovascular medicine. Contributions encompassing translational research, prospective clinical studies, and comprehensive reviews will be of particular interest.

This Topic aims to foster interdisciplinary collaboration between clinicians, imaging specialists, physiologists, and basic scientists to define new paradigms in the diagnosis and management of ischemic heart disease.

Dr. Krishnaraj Sinhji Rathod
Dr. Alexandru Corlateanu
Topic Editors