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22 Results Found

  • Article
  • Open Access

Objective: Solid pseudopapillary neoplasms (SPN) and pancreatoblastoma (PB) have a low overall incidence but represent the most common pancreatic tumors in childhood. Currently, there is a lack of systematic descriptions of contrast-enhanced ultrasou...

  • Communication
  • Open Access
8 Citations
2,515 Views
7 Pages

Background: Many previous studies have investigated the risk factors for the recurrence of pancreatic solid pseudopapillary neoplasms (SPNs), although a consensus has not yet been reached, despite this effort. We aimed to identify the predictive fact...

  • Article
  • Open Access
976 Views
13 Pages

Background: Pancreatic solid pseudopapillary neoplasms (SPNs) are rare exocrine tumours with predominance in young women. These tumours are of low malignant potential, become considerably large before causing symptoms and are associated with good pro...

  • Review
  • Open Access
10 Citations
6,529 Views
20 Pages

The Role of MRI in the Diagnosis of Solid Pseudopapillary Neoplasm of the Pancreas and Its Mimickers: A Case-Based Review with Emphasis on Differential Diagnosis

  • Jelena Djokic Kovac,
  • Aleksandra Djikic-Rom,
  • Aleksandar Bogdanovic,
  • Aleksandra Jankovic,
  • Nikica Grubor,
  • Goran Djuricic and
  • Vladimir Dugalic

Solid pseudopapillary neoplasm (SPN) is rare pancreatic tumor occurring most commonly in young females. The typical imaging appearance of SPN is of well-defined, encapsulated, and large heterogeneous tumors, consisting of solid and cystic components...

  • Article
  • Open Access
1 Citations
3,137 Views
14 Pages

Surgical Outcomes of Pancreatic Solid Pseudopapillary Neoplasm: Experiences of 24 Patients in a Single Institute

  • Peng-Yu Ku,
  • Shao-Bin Cheng,
  • Yi-Ju Chen,
  • Chia-Yu Lai,
  • Hsiao-Tien Liu and
  • Wei-Hsin Chen

Background and Objectives: The pancreatic solid pseudopapillary neoplasm (SPN), a rare tumor predominantly affecting young women, has seen an increased incidence due to improved imaging and epidemiological knowledge. This study aimed to understand th...

  • Review
  • Open Access
2 Citations
2,678 Views
20 Pages

4 July 2025

Background: Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor with malignant potential. Its diagnosis has grown alongside increased use of abdominal imaging. SPN is suspected after classical findings in abdominal imaging studies; howeve...

  • Article
  • Open Access
11 Citations
3,722 Views
16 Pages

Introduction. Pancreatic solid-pseudopapillary neoplasm (SPN) is a rare tumor that typically occurs in young females. Although a cytological diagnosis may be easily made in this age group when there are typical features, atypical clinical presentatio...

  • Article
  • Open Access
430 Views
10 Pages

Solid Pseudopapillary Neoplasm of the Pancreas: EUS Features and Diagnostic Accuracy of EUS-Guided Fine Needle Biopsy Using a 22-Gauge Fork-Tip Needle in a High Volume Center

  • Nicolò de Pretis,
  • Pietro Mastella,
  • Roberto Baldan,
  • Luigi Martinelli,
  • William Mantovani,
  • Federico Caldart,
  • Salvatore Crucillà,
  • Claudio Luchini,
  • Paola Mattiolo and
  • Luca Frulloni
  • + 8 authors

20 November 2025

Background and Aims: Solid pseudopapillary neoplasms (SPN) are rare neoplasms of the pancreatic gland. Despite the indolent behavior, surgical resection is required according to the risk of metastasis development. Few data are available on endoscopic...

  • Article
  • Open Access
10 Citations
2,269 Views
10 Pages

27 April 2021

Predicting the aggressiveness of solid pseudopapillary neoplasms (SPNs) remains an important goal. The present study aimed to identify perioperative factors that can predict patients who will develop clinically aggressive SPN. Records of individuals...

  • Review
  • Open Access
17 Citations
5,367 Views
12 Pages

Pancreatic Cystic Lesions: Pathogenesis and Malignant Potential

  • Antoinette J. Pusateri and
  • Somashekar G. Krishna

Pancreatic cancer remains one of the most lethal cancers despite extensive research. Further understanding of precursor lesions may enhance the ability to treat and prevent pancreatic cancer. Pancreatic cystic lesions (PCLs) with malignant potential...

  • Review
  • Open Access
5 Citations
3,398 Views
19 Pages

Rare Non-Neuroendocrine Pancreatic Tumours

  • Agata Mormul,
  • Emilia Włoszek,
  • Julia Nowoszewska,
  • Marta Fudalej,
  • Michał Budzik,
  • Anna Badowska-Kozakiewicz and
  • Andrzej Deptała

9 April 2023

The most common tumour of the pancreas is ductal adenocarcinoma (PDAC). It remains one of the most lethal non-neuroendocrine solid tumours despite the use of a multi-approach strategy. Other, less-common neoplasms, which are responsible for 15% of pa...

  • Article
  • Open Access
6 Citations
3,184 Views
10 Pages

Clinical Course, Genetic, and Immunohistochemical Characterization of Solid Pseudopapillary Tumor of the Pancreas (Frantz Tumors) in a Brazilian Cohort

  • Francinne T. Tostes,
  • Parisina Fraga Dutra Cabral de Carvalho,
  • Raphael L. C. Araújo,
  • Rodrigo Chaves Ribeiro,
  • Franz Robert Apodaca-Torrez,
  • Edson José Lobo,
  • Diogo Bugano Diniz Gomes,
  • Donato Callegaro-Filho,
  • Gustavo Schvartsman and
  • Pedro Luiz Serrano Uson Junior
  • + 5 authors

6 October 2022

Frantz tumors or solid pseudopapillary pancreatic neoplasm (SPN) are rare exocrine neoplasms that carry a favorable prognosis; they represent up to 3% of all tumors located in the region of the pancreas and have specific age and gender predisposition...

  • Article
  • Open Access
5 Citations
3,721 Views
15 Pages

Pancreatic Cystic Tumors: A Single-Center Observational Study

  • Beata Jabłońska,
  • Arkadiusz Gudz,
  • Tomasz Hinborch,
  • Bartosz Bujała,
  • Katarzyna Biskup and
  • Sławomir Mrowiec

27 January 2023

Background and Objectives: The aim of the study was to analyze the prevalence and characteristics of pancreatic cystic tumors (PCTs). Material and Methods: A retrospective analysis of the medical records of 124 patients, 102 (69%) women and 46 (31%)...

  • Case Report
  • Open Access
19 Citations
3,565 Views
10 Pages

Solid Pseudopapillary Neoplasm of the Pancreas and Abdominal Desmoid Tumor in a Patient Carrying Two Different BRCA2 Germline Mutations: New Horizons from Tumor Molecular Profiling

  • Andrea Mafficini,
  • Rita T. Lawlor,
  • Claudio Ghimenton,
  • Davide Antonello,
  • Cinzia Cantù,
  • Gaetano Paolino,
  • Alessia Nottegar,
  • Maria L. Piredda,
  • Roberto Salvia and
  • Claudio Luchini
  • + 4 authors

26 March 2021

This case report describes the history of a 41 year-old woman with a solid pseudopapillary neoplasm (SPN) of the pancreas and a metachronous abdominal desmoid tumor (DT) that occurred two years after the SPN surgical resection. At next-generation seq...

  • Review
  • Open Access
7 Citations
5,228 Views
21 Pages

Diagnostic, Structured Classification and Therapeutic Approach in Cystic Pancreatic Lesions: Systematic Findings with Regard to the European Guidelines

  • Christopher Kloth,
  • Benedikt Haggenmüller,
  • Annika Beck,
  • Martin Wagner,
  • Marko Kornmann,
  • Jochen P. Steinacker,
  • Nora Steinacker-Stanescu,
  • Daniel Vogele,
  • Meinrad Beer and
  • Stefan A. Schmidt
  • + 1 author

Due to the increasing use of cross-sectional imaging techniques and new technical possibilities, the number of incidentally detected cystic lesions of the pancreas is rapidly increasing in everyday radiological routines. Precise and rapid classificat...

  • Review
  • Open Access
464 Views
18 Pages

Pancreatic Cystic Lesions: From Basic Knowledge to Recent Guidelines

  • Ginevra Danti,
  • Ludovica Scalzone,
  • Lavinia Mattolini,
  • Matilde Anichini,
  • Francesca Treballi,
  • Linda Calistri,
  • Diletta Cozzi and
  • Vittorio Miele

11 January 2026

Pancreatic cystic lesions (PCLs) are increasingly detected due to widespread use of cross-sectional imaging. They encompass a heterogeneous group of lesions, ranging from benign pseudocysts and serous cystic neoplasms (SCNs) to premalignant mucinous...

  • Article
  • Open Access
34 Citations
6,699 Views
12 Pages

Somatic Genetic Variation in Solid Pseudopapillary Tumor of the Pancreas by Whole Exome Sequencing

  • Meng Guo,
  • Guopei Luo,
  • Kaizhou Jin,
  • Jiang Long,
  • He Cheng,
  • Yu Lu,
  • Zhengshi Wang,
  • Chao Yang,
  • Jin Xu and
  • Chen Liu
  • + 2 authors

Solid pseudopapillary tumor of the pancreas (SPT) is a rare pancreatic disease with a unique clinical manifestation. Although CTNNB1 gene mutations had been universally reported, genetic variation profiles of SPT are largely unidentified. We conducte...

  • Case Report
  • Open Access
1 Citations
2,265 Views
9 Pages

Primary Solid Pseudopapillary Tumor of the Ovary: A Case Report and Review of the Literature

  • Juhun Lee,
  • Seung Ho Song,
  • In Hee Lee,
  • Dong Ja Kim and
  • Hyun Jung Lee

9 May 2024

Introduction: Solid pseudopapillary neoplasms (SPNs) are rare and mainly originate from the pancreas. SPNs originating from the ovary (SPN-O) are extremely rare, and only 13 cases have been reported in the English literature since 2010. Case: We repo...

  • Article
  • Open Access
23 Citations
2,943 Views
9 Pages

Diagnostic Fine-Needle Biopsy of Small Solid Pancreatic Lesions Using a Franseen Needle during Endoscopic Ultrasound Examination

  • Kosuke Takahashi,
  • Ichiro Yasuda,
  • Tatsuyuki Hanaoka,
  • Yuka Hayashi,
  • Yasuhiro Araki,
  • Iori Motoo,
  • Shinya Kajiura,
  • Takayuki Ando,
  • Haruka Fujinami and
  • Terumi Takahara
  • + 2 authors

Background and aim: During endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNB), Franseen needles can help collect sufficient tissue to permit histopathological assessment. However, its efficacy might be limited by the size of the tar...

  • Review
  • Open Access
7 Citations
5,450 Views
42 Pages

Rare Solid Pancreatic Lesions on Cross-Sectional Imaging

  • Ana Veron Sanchez,
  • Nuria Santamaria Guinea,
  • Silvia Cayon Somacarrera,
  • Ilias Bennouna,
  • Martina Pezzullo and
  • Maria Antonietta Bali

21 August 2023

Several solid lesions can be found within the pancreas mainly arising from the exocrine and endocrine pancreatic tissue. Among all pancreatic malignancies, the most common subtype is pancreatic ductal adenocarcinoma (PDAC), to a point that pancreatic...

  • Article
  • Open Access
7 Citations
2,294 Views
19 Pages

Rare Pancreatic/Peripancreatic Cystic Lesions Can Be Accurately Characterized by EUS with Through-the-Needle Biopsy—A Unique Pictorial Essay with Clinical and Histopathological Correlations

  • Maria Cristina Conti Bellocchi,
  • Erminia Manfrin,
  • Alessandro Brillo,
  • Laura Bernardoni,
  • Andrea Lisotti,
  • Pietro Fusaroli,
  • Alice Parisi,
  • Sokol Sina,
  • Antonio Facciorusso and
  • Stefano Francesco Crinò
  • + 1 author

14 December 2023

Due to their aspecific macroscopic appearance, uncommon pancreatic cystic lesions (PCLs) are often misdiagnosed as mucinous lesions and improperly resected. We aimed to evaluate the endoscopic ultrasound (EUS)-guided through-the-needle biopsy (TTNB)...

  • Article
  • Open Access
12 Citations
3,595 Views
18 Pages

Pancreatic Mass Characterization Using IVIM-DKI MRI and Machine Learning-Based Multi-Parametric Texture Analysis

  • Archana Vadiraj Malagi,
  • Sivachander Shivaji,
  • Devasenathipathy Kandasamy,
  • Raju Sharma,
  • Pramod Garg,
  • Siddhartha Datta Gupta,
  • Shivanand Gamanagatti and
  • Amit Mehndiratta

Non-invasive characterization of pancreatic masses aids in the management of pancreatic lesions. Intravoxel incoherent motion-diffusion kurtosis imaging (IVIM-DKI) and machine learning-based texture analysis was used to differentiate pancreatic masse...