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12 Results Found

  • Article
  • Open Access
7 Citations
3,755 Views
15 Pages

The Challenging Diagnosis of Pediatric Multisystem Inflammatory Syndrome Associated with Sars-Cov-2 Infection-Two Case Reports and Literature Review

  • Marcela Daniela Ionescu,
  • Roxana Taras,
  • Bianca Dombici,
  • Mihaela Balgradean,
  • Elena Camelia Berghea and
  • Alin Nicolescu

19 April 2021

Severe acute respiratory coronavirus 2 (SARS-CoV-2) is a novel coronavirus discovered in 2019 that caused the coronavirus disease 2019 (COVID19). During the last year, over 70 million people were infected and more than 1.5 million people died. Despit...

  • Article
  • Open Access
36 Citations
7,634 Views
14 Pages

Pediatric Inflammatory Multisystem Syndrome (PIMS) Did Occur in Poland during Months with Low COVID-19 Prevalence, Preliminary Results of a Nationwide Register

  • Magdalena Okarska-Napierała,
  • Kamila M. Ludwikowska,
  • Leszek Szenborn,
  • Natalia Dudek,
  • Anna Mania,
  • Piotr Buda,
  • Janusz Książyk,
  • Katarzyna Mazur-Malewska,
  • Magdalena Figlerowicz and
  • Ernest Kuchar
  • + 13 authors

22 October 2020

Pediatric inflammatory multisystem syndrome (PIMS) is a new entity in children, likely associated with previous coronavirus disease 19 (COVID-19) infection. Most of the reports about PIMS come from countries particularly hit by the COVID-19 pandemic....

  • Article
  • Open Access
892 Views
13 Pages

The X-Linked TLR7 rs179008 T Allele Is Associated with an Increased Risk of Severe Multisystem Inflammatory Syndrome in Children/Kawasaki-like Syndrome in SARS-CoV-2-Infected Boys

  • Adriana de Souza Andrade,
  • Aline Almeida Bentes,
  • Lilian Martins Diniz,
  • Silvia Hees Carvalho,
  • Erna Geessien Kroon and
  • Marco Antonio Campos

1 September 2025

The X-linked TLR7 rs179008 T allele has been associated with altered antiviral immunity. Given their shared inflammatory pathways and higher pediatric mortality rates in Brazil during the pandemic, we investigated their association with multisystem i...

  • Review
  • Open Access
27 Citations
16,045 Views
19 Pages

4 November 2020

Intravenous immune globulin (IVIG) is made after processing plasma from healthy donors. It is composed mainly of pooled immunoglobulin and has clinical evidence-based applications in adult and pediatric populations. Recently, several clinical applica...

  • Article
  • Open Access
3 Citations
2,363 Views
11 Pages

“Multisystem Inflammatory Syndrome in Children” (MIS-C) after COVID-19 Infection in the Metropolitan Area of Nuremberg-Erlangen, Germany—Expectations and Results of a Two-Year Period

  • Steven Hébert,
  • Marius Schmidt,
  • Georg Topf,
  • Daniel Rieger,
  • Jens Klinge,
  • Jan Vermehren,
  • Christoph Fusch,
  • Christian Grillhösl,
  • Michael Schroth and
  • André Hoerning
  • + 6 authors

9 August 2023

Background: Multisystemic Inflammatory Syndrome in children (MIS-C) is a rare autoimmune disorder occurring after a latency period following acute SARS-CoV-2 infection. The therapeutic regime of MIS-C is adapted to the therapy of the Kawasaki disease...

  • Review
  • Open Access
4 Citations
3,074 Views
26 Pages

Proteomic Signatures of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Narrative Review

  • Maria-Myrto Dourdouna,
  • Elizabeth-Barbara Tatsi,
  • Vasiliki Syriopoulou and
  • Athanasios Michos

26 September 2024

Background/Objectives: Multisystem Inflammatory Syndrome in Children (MIS-C) is a post-infectious complication of COVID-19. MIS-C has overlapping features with other pediatric inflammatory disorders including Kawasaki Disease (KD), Macrophage Activat...

  • Article
  • Open Access
2,945 Views
12 Pages

Immune Responses to Some Viral Infections That Have a High Evolutionary Potential—A Case Report with Literature Review

  • Maria Lucia Sur,
  • Bogdan-Stefan Moldovan,
  • Diana Mocanu,
  • Gabriel Samasca,
  • Iulia Lupan,
  • Ionel Armat,
  • Marin Harabagiu,
  • Genel Sur and
  • Calin Lazar

23 June 2022

Viral infections are a key issue in modern medicine. SARS-CoV-2 infection confirms that we are not sufficiently prepared for these unforeseen infections. The COVID-19 pandemic has cultivated a great sense of fear and distrust in patients. If viral in...

  • Review
  • Open Access
80 Citations
11,687 Views
14 Pages

In recent weeks, several reports have emerged of skin lesions with different clinical presentations in COVID-19 cases. All dermatologists should be aware of these cutaneous lesions, which may be early clinical symptoms of infection. We reviewed the l...

  • Review
  • Open Access
1 Citations
2,204 Views
15 Pages

16 July 2024

Multisystem inflammatory syndrome in children (MIS-C) is a disease that made its mark in the early days of the COVID-19 pandemic due to the diverse course and symptoms affecting multiple body systems. It is a condition that develops in pediatric pati...

  • Review
  • Open Access
302 Citations
39,213 Views
24 Pages

Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms

  • Bruno Silva Andrade,
  • Sérgio Siqueira,
  • Wagner Rodrigues de Assis Soares,
  • Fernanda de Souza Rangel,
  • Naiane Oliveira Santos,
  • Andria dos Santos Freitas,
  • Priscila Ribeiro da Silveira,
  • Sandeep Tiwari,
  • Khalid J Alzahrani and
  • Debmalya Barh
  • + 2 authors

18 April 2021

The COVID-19 pandemic has infected millions worldwide, leaving a global burden for long-term care of COVID-19 survivors. It is thus imperative to study post-COVID (i.e., short-term) and long-COVID (i.e., long-term) effects, specifically as local and...

  • Article
  • Open Access
21 Citations
2,903 Views
13 Pages

Circulating Endothelial Cells: A New Possible Marker of Endothelial Damage in Kawasaki Disease, Multisystem Inflammatory Syndrome in Children and Acute SARS-CoV-2 Infection

  • Marianna Fabi,
  • Biljana Petrovic,
  • Laura Andreozzi,
  • Elena Corinaldesi,
  • Emanuele Filice,
  • Carlotta Biagi,
  • Alessia Rizzello,
  • Bianca Elisa Mattesini,
  • Simone Bugani and
  • Marcello Lanari

3 September 2022

Background: Kawasaki Disease (KD) and Multisystem Inflammatory Syndrome in Children (MIS-C) are pediatric diseases characterized by systemic inflammation and vascular injury, potentially leading to coronary artery lesions (CALs). Data on vascular inj...

  • Article
  • Open Access
2 Citations
2,438 Views
17 Pages

Kawasaki Disease Diagnosis and Treatment in over 1000 Patients: A Continuum of Dysregulated Inflammatory Responses

  • Stejara A. Netea,
  • Giske Biesbroek,
  • Diana van Stijn,
  • Sietse Q. Nagelkerke,
  • Kawasaki Study Group,
  • CAHAL Group,
  • KIRI Group,
  • Irene M. Kuipers and
  • Taco W. Kuijpers

Background: Kawasaki disease (KD) is a pediatric vasculitis, leading to coronary artery aneurysms (CAAs) in ~4–14%. Attention to the etiology and course of KD was generated by the close mimic of a SARS-CoV-2-induced phenotype, called multisyste...