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24 Results Found

  • Article
  • Open Access
1 Citations
2,401 Views
11 Pages

Influence of Left Ventricular Diastolic Dysfunction on the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve

  • Zhixin Xie,
  • Tianlong Wu,
  • Jing Mu,
  • Ping Zhang,
  • Xuan Wang,
  • Tao Liang,
  • Yihan Weng,
  • Jianfang Luo and
  • Huimin Yu

21 February 2023

Objectives: Our study aimed to demonstrate the influence of left ventricular (LV) diastolic dysfunction on the diagnostic performance of coronary computed tomography angiography-derived fractional flow reserve (CT-FFR). Methods: One hundred vessels f...

  • Article
  • Open Access
6 Citations
4,222 Views
12 Pages

Comparison of Machine Learning Computed Tomography-Based Fractional Flow Reserve and Coronary CT Angiography-Derived Plaque Characteristics with Invasive Resting Full-Cycle Ratio

  • Stefan Baumann,
  • Markus Hirt,
  • Christina Rott,
  • Gökce H. Özdemir,
  • Christian Tesche,
  • Tobias Becher,
  • Christel Weiss,
  • Svetlana Hetjens,
  • Ibrahim Akin and
  • Dirk Lossnitzer
  • + 4 authors

Background: The aim is to compare the machine learning-based coronary-computed tomography fractional flow reserve (CT-FFRML) and coronary-computed tomographic morphological plaque characteristics with the resting full-cycle ratio (RFRTM) as a novel i...

  • Review
  • Open Access
1 Citations
3,158 Views
19 Pages

Intravascular Imaging versus Physiological Assessment versus Biomechanics—Which Is a Better Guide for Coronary Revascularization

  • Miłosz Starczyński,
  • Stanisław Dudek,
  • Piotr Baruś,
  • Emilia Niedzieska,
  • Mateusz Wawrzeńczyk,
  • Dorota Ochijewicz,
  • Adam Piasecki,
  • Karolina Gumiężna,
  • Krzysztof Milewski and
  • Mariusz Tomaniak
  • + 2 authors

Today, coronary artery disease (CAD) continues to be a prominent cause of death worldwide. A reliable assessment of coronary stenosis represents a prerequisite for the appropriate management of CAD. Nevertheless, there are still major challenges pert...

  • Case Report
  • Open Access
1 Citations
3,362 Views
11 Pages

Discordance between Invasive and Non-Invasive Coronary Angiography: An In-Depth Functional and Anatomical Analysis

  • Shigetaka Kageyama,
  • Kaoru Tanaka,
  • Shinichiro Masuda,
  • Momoko Kageyama,
  • Scot Garg,
  • Adam Updegrove,
  • Johan De Mey,
  • Mark La Meir,
  • Yoshinobu Onuma and
  • Patrick W. Serruys

A 79-year-old male with chronic coronary syndrome with complex coronary artery disease was included in the first-in-man trial of surgical revascularization guided solely by coronary computed tomography angiography (CCTA) and fractional flow reserve d...

  • Article
  • Open Access
35 Citations
7,026 Views
15 Pages

Fractional Flow Reserve Derived from Coronary Computed Tomography Angiography Safely Defers Invasive Coronary Angiography in Patients with Stable Coronary Artery Disease

  • Mark Rabbat,
  • Jonathon Leipsic,
  • Jeroen Bax,
  • Brian Kauh,
  • Rina Verma,
  • Demetrios Doukas,
  • Sorcha Allen,
  • Gianluca Pontone,
  • David Wilber and
  • John Lopez
  • + 2 authors

24 February 2020

Objectives: In the United States, the real-world feasibility and outcome of using fractional flow reserve from coronary computed tomography angiography (FFRCT) is unknown. We sought to determine whether a strategy that combined coronary computed tomo...

  • Review
  • Open Access
3 Citations
4,647 Views
30 Pages

Clinical Impact of CT-Based FFR in Everyday Cardiology: Bridging Computation and Decision-Making

  • Maria Bozika,
  • Anastasios Apostolos,
  • Kassiani-Maria Nastouli,
  • Michail I. Papafaklis,
  • Ioannis Skalidis,
  • Dimitrios Terentes-Printzios,
  • Antonios Karanasos,
  • Christos Koutsogiannis-Korkontzelos,
  • Georgios Boliaris and
  • Grigorios Tsigkas
  • + 4 authors

A revolutionary non-invasive method for the thorough evaluation of coronary artery disease (CAD) is fractional flow reserve (FFR) obtained from coronary computed tomography angiography (CCTA). Computed tomography-derived FFR (FFRCT) assesses both the...

  • Article
  • Open Access
14 Citations
4,752 Views
16 Pages

Additional Value of Machine-Learning Computed Tomographic Angiography-Based Fractional Flow Reserve Compared to Standard Computed Tomographic Angiography

  • Dirk Lossnitzer,
  • Leonard Chandra,
  • Marlon Rutsch,
  • Tobias Becher,
  • Daniel Overhoff,
  • Sonja Janssen,
  • Christel Weiss,
  • Martin Borggrefe,
  • Ibrahim Akin and
  • Stefan Baumann
  • + 1 author

Background: Machine-learning-based computed-tomography-derived fractional flow reserve (CT-FFRML) obtains a hemodynamic index in coronary arteries. We examined whether it could reduce the number of invasive coronary angiographies (ICA) showing no obs...

  • Article
  • Open Access
738 Views
16 Pages

Performance of a Novel Computational Hyperemic Resistance Index Derived from Cardiac CT in Coronary Chronic Syndromes

  • Yahia Bellouche,
  • Clement Benic,
  • Sinda Hannachi,
  • Pierre Phillipe Nicol,
  • Christopher Jousse,
  • Florent Le Ven,
  • Jacques Mansourati,
  • Bastien Pasdeloup and
  • Romain Didier

15 October 2025

Background/Objectives: Coronary artery disease (CAD) remains the leading global cause of mortality, underscoring the need for functional assessments that extend beyond anatomical evaluation. The Hyperemic Stenosis Resistance (HSR) index combines inva...

  • Article
  • Open Access
7 Citations
3,294 Views
15 Pages

A Novel CT Perfusion-Based Fractional Flow Reserve Algorithm for Detecting Coronary Artery Disease

  • Xuelian Gao,
  • Rui Wang,
  • Zhonghua Sun,
  • Hongkai Zhang,
  • Kairui Bo,
  • Xiaofei Xue,
  • Junjie Yang and
  • Lei Xu

9 March 2023

Background: The diagnostic accuracy of fractional flow reserve (FFR) derived from coronary computed tomography angiography (CCTA) (FFR-CT) needs to be further improved despite promising results available in the literature. While an innovative myocard...

  • Article
  • Open Access
978 Views
17 Pages

With the advancement of fractional flow reserve (FFR) derived from computed tomography (FFRCT), virtual stenting technology has gradually developed. This study investigated the performance of virtual stenting based on FFRCT in predicting post-percuta...

  • Review
  • Open Access
17 Citations
5,558 Views
18 Pages

30 December 2022

Coronary artery disease (CAD) represents a widespread burden to both individual and public health, steadily rising across the globe. The current guidelines recommend non-invasive anatomical or functional testing prior to invasive procedures. Both cor...

  • Article
  • Open Access
9 Citations
4,701 Views
14 Pages

Feasibility and Comparison of Resting Full-Cycle Ratio and Computed Tomography Fractional Flow Reserve in Patients with Severe Aortic Valve Stenosis

  • Hendrik Wienemann,
  • Marcel C. Langenbach,
  • Victor Mauri,
  • Maryam Banazadeh,
  • Konstantin Klein,
  • Christopher Hohmann,
  • Samuel Lee,
  • Isabel Breidert,
  • Alexander Hof and
  • Matti Adam
  • + 6 authors

Background: Computed tomography derived Fractional Flow Reserve (CT-FFR) has been shown to decrease the referral rate for invasive coronary angiography (ICA). The purpose of the study was to evaluate the diagnostic performance of CT-FFR compared to h...

  • Review
  • Open Access
3 Citations
3,128 Views
13 Pages

Cardiac Computed Tomography in Monitoring Revascularization

  • Elisabetta Tonet,
  • Veronica Amantea,
  • Davide Lapolla,
  • Paolo Assabbi,
  • Alberto Boccadoro,
  • Maria Letizia Berloni,
  • Marco Micillo,
  • Federico Marchini,
  • Serena Chiarello and
  • Gianluca Campo
  • + 1 author

15 November 2023

The use of coronary computed tomography angiography (CCTA) in the setting of stable coronary artery disease is highly recommended for low-risk patients. High-risk patients, such as symptomatic subjects with prior revascularization, are suggested to b...

  • Review
  • Open Access
1 Citations
4,863 Views
20 Pages

Fractional Flow Reserve from Coronary CT: Evidence, Applications, and Future Directions

  • Arta Kasaeian,
  • Mohadese Ahmadzade,
  • Taylor Hoffman,
  • Mohammad Ghasemi-Rad and
  • Anoop Padoor Ayyappan

Coronary computed tomography angiography (CCTA) has emerged as the leading noninvasive imaging modality for the assessment of coronary artery disease (CAD), offering high-resolution visualization of the coronary anatomy and plaque characterization. T...

  • Review
  • Open Access
1,627 Views
18 Pages

Cardiac Computed Tomography for the Assessment of Myocardial Bridging: A Scoping Review of the Emerging Role of Artificial Intelligence and Machine Learning

  • Amro Abu Suleiman,
  • Federico Russo,
  • Luigi Della Valle,
  • Davide Ausiello,
  • Ewelina Bukowska-Olech,
  • Vincenzo Iannibelli,
  • M. Omar Al Droubi,
  • Gabriella Sannino,
  • Marco Bernardi and
  • Luigi Spadafora

(1) Background: Myocardial bridging (MB) is a congenital coronary anomaly with potential clinical significance. Artificial intelligence (AI) applied to cardiac computed tomography angiography (CCTA), particularly through CT-derived fractional flow re...

  • Article
  • Open Access
31 Citations
4,692 Views
17 Pages

Sequential Strategy Including FFRCT Plus Stress-CTP Impacts on Management of Patients with Stable Chest Pain: The Stress-CTP RIPCORD Study

  • Andrea Baggiano,
  • Laura Fusini,
  • Alberico Del Torto,
  • Patrizia Vivona,
  • Marco Guglielmo,
  • Giuseppe Muscogiuri,
  • Margherita Soldi,
  • Chiara Martini,
  • Enrico Fraschini and
  • Gianluca Pontone
  • + 27 authors

Stress computed tomography perfusion (Stress-CTP) and computed tomography-derived fractional flow reserve (FFRCT) are functional techniques that can be added to coronary computed tomography angiography (cCTA) to improve the management of patients wit...

  • Review
  • Open Access
611 Views
16 Pages

Multimodality Cardiovascular Imaging in Patients After Coronary Artery Bypass Grafting: Diagnosis and Risk Stratification

  • Lucia La Mura,
  • Annalisa Pasquini,
  • Adriana D′Antonio,
  • Eirini Beneki,
  • Irfan Ullah,
  • Ashot Avagimyan,
  • Mahmoud Abdelnabi,
  • Ramzi Ibrahim,
  • Vikash Jaiswal and
  • Francesco Perone

17 December 2025

Coronary artery bypass grafting (CABG) remains a cornerstone of treatment for patients with advanced or complex coronary artery disease, yet long-term success is influenced by graft patency, progression of native disease, and ventricular remodeling....

  • Article
  • Open Access
1 Citations
1,737 Views
12 Pages

Combined Computed Coronary Tomography Angiography and Transcatheter Aortic Valve Implantation (TAVI) Planning Computed Tomography Reliably Detects Relevant Coronary Artery Disease Pre-TAVI

  • Dominik Felbel,
  • Christoph Buck,
  • Natalie Riedel,
  • Michael Paukovitsch,
  • Tilman Stephan,
  • Marvin Krohn-Grimberghe,
  • Johannes Mörike,
  • Birgid Gonska,
  • Christoph Panknin and
  • Dominik Buckert
  • + 3 authors

19 August 2024

Background: Before surgical or transcatheter aortic valve implantation (TAVI), coronary status evaluation is required. The role of combined computed coronary tomography angiography (cCTA) and TAVI planning CT in this context is not yet well elucidate...

  • Review
  • Open Access
6 Citations
2,635 Views
23 Pages

The Role of Multimodality Imaging (CT & MR) as a Guide to the Management of Chronic Coronary Syndromes

  • Luigi Tassetti,
  • Enrico Sfriso,
  • Francesco Torlone,
  • Andrea Baggiano,
  • Saima Mushtaq,
  • Francesco Cannata,
  • Alberico Del Torto,
  • Fabio Fazzari,
  • Laura Fusini and
  • Gianluca Pontone
  • + 13 authors

13 June 2024

Chronic coronary syndrome (CCS) is one of the leading cardiovascular causes of morbidity, mortality, and use of medical resources. After the introduction by international guidelines of the same level of recommendation to non-invasive imaging techniqu...

  • Article
  • Open Access
5 Citations
2,421 Views
12 Pages

22 December 2022

This study aimed to assess and compare the efficiency of non-invasive imaging modalities in detecting myocardial ischemia in patients with suspected stable angina as easy-to-understand indices. Our study included 1000 patients with chest pain and pos...

  • Article
  • Open Access
288 Views
13 Pages

Impact of Diabetes on Management and Outcomes in Patients with Borderline FFRCT

  • Yanchun Chen,
  • Zhan Feng,
  • Wenjing Jia,
  • Xiaoyu Ma,
  • Zhengjie He,
  • Hui Lou,
  • Hongjie Hu,
  • Zhen Zhou and
  • Lei Xu

Background: The impact of diabetes on the management and outcomes of patients with borderline CT-derived fractional flow reserve (FFRCT) remains unclear. Methods: This multicenter study enrolled symptomatic patients with suspected coronary artery dis...

  • Article
  • Open Access
4 Citations
3,189 Views
16 Pages

Diagnostic Performance of On-Site Computed Tomography Derived Fractional Flow Reserve on Non-Culprit Coronary Lesions in Patients with Acute Coronary Syndrome

  • Abdelkrim Ahres,
  • Judit Simon,
  • Balazs Jablonkai,
  • Bela Nagybaczoni,
  • Tamas Baranyai,
  • Astrid Apor,
  • Marton Kolossvary,
  • Bela Merkely,
  • Pal Maurovich-Horvat and
  • Peter Andrassy
  • + 1 author

8 November 2022

The role of coronary computed tomography angiography (CCTA) derived fractional flow reserve (CT-FFR) in the assessment of non-culprit lesions (NCL) in patients with acute coronary syndrome (ACS) is debated. In this prospective clinical study, a total...

  • Article
  • Open Access
9 Citations
4,694 Views
14 Pages

Background: Coronary computed tomography angiography (CCTA) is an established first-line test in the investigation of patients with suspected coronary artery disease (CAD), while the perivascular fat attenuation index (FAI) derived from CT seems to b...

  • Review
  • Open Access
2,634 Views
15 Pages

11 September 2023

Purpose of Review: Functional stress testing is frequently used to assess for coronary artery disease (CAD) in symptomatic, stable patients with low to intermediate pretest probability. However, patients with highly vulnerable plaque may have preserv...