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18 Results Found

  • Article
  • Open Access
4 Citations
2,503 Views
8 Pages

Basal cell carcinoma (BCC) is the most common keratinocyte carcinoma and the most prevalent skin cancer in humans, worldwide. BCC is histologically characterized by the proliferation of basaloid cells, arranged in globular masses of varying size, oft...

  • Case Report
  • Open Access
4 Citations
5,458 Views
8 Pages

Histological and Immunohistochemical Features of Trichoblastoma in a Sarda Breed Sheep

  • Marta Polinas,
  • Giovanni P. Burrai,
  • Veronica Vitiello,
  • Laura Falchi,
  • Maria T. Zedda,
  • Gerolamo Masala,
  • Vincenzo Marras,
  • Giulia Satta,
  • Alberto Alberti and
  • Elisabetta Antuofermo

4 November 2020

Skin tumors with adnexal differentiation are commonly reported in dogs and cats, while only anecdotal evidence is available in sheep. Here we illustrate the macroscopic, histologic, and immunohistochemical features of a cutaneous lesion with adnexal...

  • Article
  • Open Access
2,729 Views
20 Pages

Canine Visceral Leishmaniasis: A Histological and Immunohistochemical Study of Fibropoiesis in Chronic Interstitial Pneumonitis

  • Frederico C. Gonçalves,
  • Ramon de Alencar Pereira,
  • Adriano Francisco Alves,
  • Aldair Pinto Woyames Junio,
  • Ricardo T. Fujiwara,
  • David M. Mosser,
  • Helida Monteiro Andrade,
  • Geovanni D. Cassali,
  • Enio Ferreira and
  • Wagner Luiz Tafuri

We studied some fibrotic aspects of chronic interstitial pneumonitis in the lungs of dogs infected with Leishmania infantum. The lungs of eleven naturally infected dogs, twelve experimentally infected with two distinct strains of L. infantum (BH401 a...

  • Article
  • Open Access
3 Citations
2,422 Views
24 Pages

14 November 2022

The immunolocalization of the cytoskeletal and the extracellular matrix proteins was investigated in the testicular excurrent duct system of healthy Japanese quail at 4, 6–7, 12 and 52 weeks of age. TdT dUTP Nick End Labeling (TUNEL) assay was...

  • Case Report
  • Open Access
1 Citations
1,903 Views
11 Pages

17 December 2024

Atypical polypoid adenomyoma (APA) is a benign uterine lesion with a premalignant potential and occurs in women of reproductive age. The histological pattern is characterized by irregular epithelial proliferation and muscular stroma. Based on a case...

  • Article
  • Open Access
1,293 Views
20 Pages

Hepatic Histopathological Benefit, Microbial Cost: Oral Vancomycin Mitigates Non-Alcoholic Fatty Liver Disease While Disrupting the Cecal Microbiota

  • Gül Çirkin,
  • Selma Aydemir,
  • Burcu Açıkgöz,
  • Aslı Çelik,
  • Yunus Güler,
  • Müge Kiray,
  • Başak Baykara,
  • Ener Çağrı Dinleyici and
  • Yeşim Öztürk

4 September 2025

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) encompasses a spectrum of liver conditions and involves gut–liver axis crosstalk. We aimed to evaluate whether oral vancomycin modifies liver injury and the ceca...

  • Article
  • Open Access
25 Citations
4,558 Views
17 Pages

Silver Nanoparticle-Coated Polyhydroxyalkanoate Based Electrospun Fibers for Wound Dressing Applications

  • Ozlem Ipek Kalaoglu-Altan,
  • Havva Baskan,
  • Timo Meireman,
  • Pooja Basnett,
  • Bahareh Azimi,
  • Alessandra Fusco,
  • Niccola Funel,
  • Giovanna Donnarumma,
  • Andrea Lazzeri and
  • Ipsita Roy
  • + 2 authors

28 August 2021

Wound dressings are high performance and high value products which can improve the regeneration of damaged skin. In these products, bioresorption and biocompatibility play a key role. The aim of this study is to provide progress in this area via nano...

  • Review
  • Open Access
2 Citations
2,435 Views
11 Pages

Leiomyomas are common lesions that are usually located in the genitourinary and gastrointestinal tracts. Primary leiomyomas at the skull base are uncommon. They are composed of well-differentiated smooth muscle cells without cellular atypia. The diag...

  • Communication
  • Open Access
4 Citations
3,280 Views
9 Pages

l-Lactate Dehydrogenase B Chain Associated with Milk Protein Content in Dairy Cows

  • Tao Wang,
  • Seung Woo Jeon,
  • U Suk Jung,
  • Min Jeong Kim and
  • Hong Gu Lee

15 July 2019

This study aimed to explore genes associated with milk protein content in dairy cows and their relationships with l-leucine. Ten primiparous Holstein cows (93.8 ± 11.56 milking days) fed the same diet were divided into two groups depending on...

  • Case Report
  • Open Access
13 Citations
4,698 Views
9 Pages

Low-Grade Myofibroblastic Sarcoma of the Oral Cavity: A Report of Three Cases Illustrating an Emerging Disease in Children

  • Primali Rukmal Jayasooriya,
  • Chamara Athukorala,
  • Manjula Attygalla,
  • Balapuwaduge Ranjit Rigobert Nihal Mendis and
  • Tommaso Lombardi

Low-grade myofibroblastic sarcoma (LGMS) is a mesenchymal tumor of myofibroblasts that occurs more frequently in adults. A series of three cases is presented to illustrate that LGMS may also occur within the oral cavity in children and adolescents. T...

  • Article
  • Open Access
5 Citations
1,868 Views
13 Pages

14 July 2023

We investigated the diagnostic capacity of selected circulating biomarkers (CBMs) for the early detection of bone metastasis (BMets) in patients with pancreatic neuroendocrine neoplasms (PanNENs). A total of 115 patients with PanNENs and 40 controls...

  • Article
  • Open Access
14 Citations
6,055 Views
10 Pages

Background: The present study aims to evaluate the diagnostic roles of various immunohistochemical (IHC) markers in thymic tumors, including thymic carcinoma (TC) and thymoma (TM). Methods: Eligible studies were obtained by searching the PubMed datab...

  • Article
  • Open Access
26 Citations
3,727 Views
12 Pages

Gene Expression Profiling of Olfactory Neuroblastoma Helps Identify Prognostic Pathways and Define Potentially Therapeutic Targets

  • Chiara Romani,
  • Eliana Bignotti,
  • Davide Mattavelli,
  • Anna Bozzola,
  • Luigi Lorini,
  • Michele Tomasoni,
  • Laura Ardighieri,
  • Vittorio Rampinelli,
  • Alberto Paderno and
  • Simonetta Battocchio
  • + 16 authors

21 May 2021

Olfactory neuroblastoma (ONB) is a rare sinonasal neoplasm with a peculiar behavior, for which limited prognostic factors are available. Herein, we investigate the transcriptional pathways altered in ONB and correlate them with pathological features...

  • Article
  • Open Access
4 Citations
3,846 Views
12 Pages

Acetyl-L-Carnitine and Liposomal Co-Enzyme Q10 Attenuate Hepatic Inflammation, Apoptosis, and Fibrosis Induced by Propionic Acid

  • Ahlam M. Alhusaini,
  • Rahaf Alsoghayer,
  • Lina Alhushan,
  • Abeer M. Alanazi and
  • Iman H. Hasan

Propionic acid (PRA) is a metabolic end-product of enteric bacteria in the gut, and it is commonly used as a food preservative. Despite the necessity of PRA for immunity in the body, excessive exposure to this product may result in disruptive effects...

  • Article
  • Open Access
7 Citations
4,547 Views
17 Pages

Secretome Analysis of Inductive Signals for BM-MSC Transdifferentiation into Salivary Gland Progenitors

  • Mahmoud Mona,
  • Firas Kobeissy,
  • Yun-Jong Park,
  • Rehae Miller,
  • Wafaa Saleh,
  • Jin Koh,
  • Mi-Jeong Yoo,
  • Sixue Chen and
  • Seunghee Cha

28 November 2020

Severe dry mouth in patients with Sjögren’s Syndrome, or radiation therapy for patients with head and neck cancer, significantly compromises their oral health and quality of life. The current clinical management of xerostomia is limited to...

  • Article
  • Open Access
5 Citations
1,230 Views
9 Pages

Baricitinib Mitigates Methotrexate-Induced Liver Fibrosis Model via YAP Pathway

  • Mehmet Ulusan,
  • Mumin Alper Erdogan,
  • Ozkan Simsek,
  • Zafer Dogan,
  • Bertug Bekir Ciftci,
  • Gultekin Atalan and
  • Oytun Erbas

Background and Objectives: Liver fibrosis, a chronic process caused by various pathogenic factors, including drug toxicity, metabolic disorders, and chronic inflammation, is associated with liver-related mortality rates worldwide. It has been establi...

  • Article
  • Open Access
1 Citations
1,099 Views
11 Pages

Pyridostigmine Mitigates Methotrexate-Induced Liver Fibrosis in Rats: Association with Changes in BMP-9, SIRT1, and Endoglin Expression

  • Mehmet Ulusan,
  • Mumin Alper Erdogan,
  • Ozkan Simsek,
  • Hilal Ustundag,
  • Zafer Dogan,
  • Bertug Bekir Ciftci,
  • Mesih Kocamuftuoglu,
  • Imdat Orhan and
  • Oytun Erbas

Background and Objectives: Methotrexate (MTX) is a widely utilised pharmaceutical agent in the treatment of various malignancies and inflammatory diseases. However, its clinical utility is often constrained by its potential for hepatotoxicity. Althou...

  • Review
  • Open Access
26 Citations
5,332 Views
17 Pages

27 December 2019

Liver injuries caused by the use of exogenous compounds such as drugs, herbs, and alcohol are commonly well diagnosed using laboratory tests, toxin analyses, or eventually reactive intermediates generated during metabolic degradation of the respectiv...