13 Results Found

Currently the 25-hydroxy vitamin D (25(OH)D) concentration is thought to be the best estimate of the vitamin D status of an individual. Unfortunately, its measurement remains complex, despite recent technological advances. We evaluated the biological...

Rotational thromboelastometry (ROTEM) is a viscoelastic hemostasis test used primarily in the management of bleeding after trauma or in cardiac surgery. To allow safe and valid clinical interpretation of test results, objective specifications for ana...

Nanomaterial-based aptasensors serve as useful instruments for detecting small biological entities. This work utilizes data gathered from three electrochemical aptamer-based sensors varying in receptors, analytes of interest, and lengths of signals....

Background: Glial fibrillary acidic protein (GFAP) is an important biomarker for neuroinflammatory conditions. Recently, advancements in the treatment of neurological diseases have highlighted the increasing importance of biomarkers, creating a deman...

Extracellular vesicles (EVs) are known as potential biomarkers for several diseases; nevertheless, the degree of technical and biological variability is not yet adequately characterized. Because pre-analytical factors such as blood collection time an...

Cortisol measurement in dogs commonly supports the diagnosis of hypercortisolism or hypoadrenocorticism. Unlike serum cortisol, urine cortisol is less affected by daily fluctuations, and collection is non-invasive, making the urine cortisol-to-creati...

YKL-40 is a glycoprotein that may be present at elevated levels in many cancers and neurodegenerative diseases. It has been investigated in numerous studies as a potential biomarker for several conditions, including Alzheimer’s Disease (AD). In...

The metabolome is the underlying biochemical layer of the phenotype and offers a functional readout of the cellular mechanisms involved in a biological system. Since metabolites are considered end-products of regulatory processes at a cellular level,...

The aim of this article review is to analyze some models and clinical issues related to the implementation of accelerated diagnostic protocols based on specific cardiac biomarkers in patients admitted to the emergency department (ED) with symptoms co...

Vitamin B12 (VB12) is an important nutrient, and its quality control in food is crucial. In this study, based on the principle of specific recognition of target analyte by monoclonal antibodies (mAbs), a time-resolved fluorescent microsphere immunoch...

Background: Rigorous evaluation of vacuum blood collection tubes is essential to ensure the reliability of laboratory results. Methods: In this study, we compared the serum separator tube V-Tube™ (V-Tube SST), the quick-clotting serum separator...

Background: We compared the performance of 21 different assays performed by the Wantai Wan200+ (Wantai BioPharm, Beijing, China) with respect to other methods in use at the University Hospital of Padova (AOPD), Italy. Methods: The plasma (P) or serum...

Introduction: Vibrational spectroscopy (VS) is a new and rapidly evolving technology in cancer diagnostics. Originating from analytical chemistry, VS evaluates vibrations of nuclei to produce a unique “biological fingerprint.” While multiple studies...