12 Results Found

Pilot bioavailability/bioequivalence (BA/BE) studies are downsized trials that can be conducted prior to the definitive pivotal trial. In these trials, 12 to 18 subjects are usually enrolled, although, in principle, a sample size is not formally calc...

The bidirectional reflectance distribution function (BRDF) factor ƒ′ provides a bridge between the inherent and apparent optical properties (IOPs and AOPs) of inland waters. The previous BRDF studies focused on ocean waters, while few stud...

Pilot bioavailability/bioequivalence (BA/BE) studies are usually conducted and analysed similarly to pivotal studies. Their analysis and interpretation of results usually rely on the application of the average bioequivalence approach. However, due to...

Over the past few decades, general relativity and the concordance ΛCDM model have been successfully tested using several different astrophysical and cosmological probes based on large datasets (precision cosmology). Despite their successes, some shor...

Isomers of hexachlorocyclohexanes (HCHs) and metabolites of dichlorodiphenyltrichloroethanes (DDTs) are still frequently detected worldwide in considerable amounts, even decades after their prohibition. Carbonaceous materials (CMs) have been shown to...

Bacterial resistance and antibiotic drug effectiveness can be related to administering generic products with a subtherapeutic dose or poor in vivo drug release. The aim of this study was to investigate whether locally marketed amoxicillin tablets hav...

Purpose: To review in vitro testing and simulation platforms that are in current use to predict in vivo performances of generic products as well as other situations to provide evidence for biowaiver and support drug formulations development. Methods:...

In order to reveal the formation mechanism of different garnets and its implications for the fluid evolution in the Laoshankou Fe-Cu-Au deposit in the northern margin of East Junggar (NW China), three types of garnet have been investigated in detail...

This paper describes the design, fabrication, and characterization of tightly focused (ƒ-number close to 1) high frequency needle-type transducers based on lead-free Na0.5Bi4.5Ti3.975Co0.025O15 (NBT-Co) piezo-ceramics. The NBT-Co ceramics, are f...

Converting graphene oxide (GO) nanosheets into high-performance paper-like GO films has significant practical value. However, it is still challenging because the mechanical properties significantly decreased when the nanosheets are assembled into fil...

The recently discovered 460 Gaodi porphyry Mo-Cu deposit is a sub-economic deposit characterized by low Mo-Cu grades, dispersed mineralization, and separated Mo- and Cu-ore bodies. This study aims to elucidate the factors underlying this type of sub-...

Emerging research suggests that body dissatisfaction (BD) is prevalent among midlife and older women (i.e., upwards of 70%). Cross-sectionally, BD is associated with myriad poor health and wellness outcomes (e.g., depression, disordered eating, bad n...