Healthcare | Highly Cited Review Papers in 2025

Published online semimonthly by MDPI, Healthcare (ISSN 2227-9032) is an international, scientific, peer-reviewed, open access journal on healthcare systems, industry, technology, policy, and regulation.

All the articles published in our journal are in an open access format, granting our readers free and unlimited access to the full text. You are invited to read the highly cited papers published in 2025 and listed below.

“Emerging Evidence on Balneotherapy and Thermal Interventions in Post-COVID-19 Syndrome: A Systematic Review”
by Elisabetta Ferrara, Manela Scaramuzzino, Giovanna Murmura, Gianmaria D’Addazio and Bruna Sinjari
Healthcare 2025, 13(2), 96; https://doi.org/10.3390/healthcare13020096
Available online: https://www.mdpi.com/2227-9032/13/2/96
“The Associated Factors of Work Engagement, Work Overload, Work Satisfaction, and Emotional Exhaustion and Their Effect on Healthcare Workers: A Cross-Sectional Study”
by Marina Moreno-Martínez and Iván Sánchez-Martínez
Healthcare 2025, 13(2), 162; https://doi.org/10.3390/healthcare13020162
Available online: https://www.mdpi.com/2227-9032/13/2/162
“Identifying Access Barriers to PrEP Among Cisgender Black/African American Women in the United States: A Systematic Review of the Literature”
by JoAnna Boudreaux, Cristobal Mario Valdebenito and Latrice C. Pichon
Healthcare 2025, 13(1), 86; https://doi.org/10.3390/healthcare13010086
Available online: https://www.mdpi.com/2227-9032/13/1/86
“Assessing the Relationships of Expenditure and Health Outcomes in Healthcare Systems: A System Design Approach”
by Anca Antoaneta Vărzaru
Healthcare 2025, 13(4), 352; https://doi.org/10.3390/healthcare13040352
Available online: https://www.mdpi.com/2227-9032/13/4/352
“Effects of Motor Skills and Physical Activity Interventions on Motor Development in Children with Autism Spectrum Disorder: A Systematic Review”
by Yu Xing and Xueping Wu
Healthcare 2025, 13(5), 489; https://doi.org/10.3390/healthcare13050489
Available online: https://www.mdpi.com/2227-9032/13/5/489
“Moral Distress and Emotional Exhaustion in Healthcare Professionals: A Systematic Review and Meta-Analysis”
by Alejandro Orgambídez, Yolanda Borrego, F. Javier Alcalde and Auxiliadora Durán
Healthcare 2025, 13(4), 393; https://doi.org/10.3390/healthcare13040393
Available online: https://www.mdpi.com/2227-9032/13/4/393
“AI Applications to Reduce Loneliness Among Older Adults: A Systematic Review of Effectiveness and Technologies”
by Yuyi Yang, Chenyu Wang, Xiaoling Xiang and Ruopeng An
Healthcare 2025, 13(5), 446; https://doi.org/10.3390/healthcare13050446
Available online: https://www.mdpi.com/2227-9032/13/5/446
“The Effects of Concurrent Training Versus Aerobic or Resistance Training Alone on Body Composition in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis”
by Mousa Khalafi, Shokoufeh Kheradmand, Aref Habibi Maleki, Michael E. Symonds, Sara K. Rosenkranz and Alexios Batrakoulis
Healthcare 2025, 13(7), 776; https://doi.org/10.3390/healthcare13070776
Available online: https://www.mdpi.com/2227-9032/13/7/776
“Effects of Physical Exercise on Symptoms and Quality of Life in Women in Climacteric: A Systematic Review and Meta-Analysis”
by Providencia Juana Trujillo-Muñoz, María Angustias Sánchez-Ojeda, Eva Carolina Rodríguez-Huamán, Karima Mezyani-Haddu, Irene Hoyo-Guillot and Silvia Navarro-Prado
Healthcare 2025, 13(6), 644; https://doi.org/10.3390/healthcare13060644
Available online: https://www.mdpi.com/2227-9032/13/6/644
“Investigation into Application of AI and Telemedicine in Rural Communities: A Systematic Literature Review”
by Kinalyne Perez, Daniela Wisniewski, Arzu Ari, Kim Lee, Cristian Lieneck and Zo Ramamonjiarivelo
Healthcare 2025, 13(3), 324; https://doi.org/10.3390/healthcare13030324
Available online: https://www.mdpi.com/2227-9032/13/3/324
“A Review of Large Language Models in Medical Education, Clinical Decision Support, and Healthcare Administration”
by Josip Vrdoljak, Zvonimir Boban, Marino Vilović, Marko Kumrić and Joško Božić
Healthcare 2025, 13(6), 603; https://doi.org/10.3390/healthcare13060603
Available online: https://www.mdpi.com/2227-9032/13/6/603
“A Systematic Literature Review for Blockchain-Based Healthcare Implementations”
by Mutiullah Shaikh, Shafique Ahmed Memon, Ali Ebrahimi and Uffe Kock Wiil
Healthcare 2025, 13(9), 1087; https://doi.org/10.3390/healthcare13091087
Available online: https://www.mdpi.com/2227-9032/13/9/1087
“Ranking Nursing Diagnoses by Predictive Relevance for Intensive Care Unit Transfer Risk in Adult and Pediatric Patients: A Machine Learning Approach with Random Forest”
by Manuele Cesare, Mario Cesare Nurchis, Nursing and Public Health Group, Gianfranco Damiani and Antonello Cocchieri
Healthcare 2025, 13(11), 1339; https://doi.org/10.3390/healthcare13111339
Available online: https://www.mdpi.com/2227-9032/13/11/1339
“Bridging the Gap: From AI Success in Clinical Trials to Real-World Healthcare Implementation—A Narrative Review”
by Rabie Adel El Arab, Mohammad S. Abu-Mahfouz, Fuad H. Abuadas, Husam Alzghoul, Mohammed Almari, Ahmad Ghannam and Mohamed Mahmoud Seweid
Healthcare 2025, 13(7), 701; https://doi.org/10.3390/healthcare13070701
Available online: https://www.mdpi.com/2227-9032/13/7/701
“Technology Readiness Drives Digital Adoption in Dentistry: Insights from a Cross-Sectional Study”
by Christian Schnitzler and Sabine Bohnet-Joschko
Healthcare 2025, 13(10), 1155; https://doi.org/10.3390/healthcare13101155
Available online: https://www.mdpi.com/2227-9032/13/10/1155
“Integrating Digital Health Innovations to Achieve Universal Health Coverage: Promoting Health Outcomes and Quality Through Global Public Health Equity”
by Mohamed Mustaf Ahmed, Olalekan John Okesanya, Noah Olabode Olaleke, Olaniyi Abideen Adigun, Uthman Okikiola Adebayo, Tolutope Adebimpe Oso, Gilbert Eshun and Don Eliseo Lucero-Prisno III
Healthcare 2025, 13(9), 1060; https://doi.org/10.3390/healthcare13091060
Available online: https://www.mdpi.com/2227-9032/13/9/1060
“The Impact of AI Scribes on Streamlining Clinical Documentation: A Systematic Review”
by Maxime Sasseville, Farzaneh Yousefi, Steven Ouellet, Florian Naye, Théo Stefan, Valérie Carnovale, Frédéric Bergeron, Linda Ling, Bobby Gheorghiu, Simon Hagens et al.
Healthcare 2025, 13(12), 1447; https://doi.org/10.3390/healthcare13121447
Available online: https://www.mdpi.com/2227-9032/13/12/1447
“Endocrine and Metabolic Mechanisms Linking Obesity to Type 2 Diabetes: Implications for Targeted Therapy”
by Salvatore Allocca, Antonietta Monda, Antonietta Messina, Maria Casillo, Walter Sapuppo, Vincenzo Monda, Rita Polito, Girolamo Di Maio, Marcellino Monda and Marco La Marra
Healthcare 2025, 13(12), 1437; https://doi.org/10.3390/healthcare13121437
Available online: https://www.mdpi.com/2227-9032/13/12/1437
“Leveraging AI-Driven Neuroimaging Biomarkers for Early Detection and Social Function Prediction in Autism Spectrum Disorders: A Systematic Review”
by Evgenia Gkintoni, Maria Panagioti, Stephanos P. Vassilopoulos, Georgios Nikolaou, Basilis Boutsinas and Apostolos Vantarakis
Healthcare 2025, 13(15), 1776; https://doi.org/10.3390/healthcare13151776
Available online: https://www.mdpi.com/2227-9032/13/15/1776
“Stress, Anxiety, and Depression as Psychological Distress Among College and Undergraduate Students: A Scoping Review of Reviews Guided by the Socio-Ecological Model”
by Sharmistha Roy, Ashis Kumar Biswas and Manoj Sharma
Healthcare 2025, 13(16), 1948; https://doi.org/10.3390/healthcare13161948
Available online: https://www.mdpi.com/2227-9032/13/16/1948

You can browse more high-impact research by visiting our Most Cited & Viewed section, where all full-text articles are freely accessible: https://www.mdpi.com/journal/healthcare/most_cited.

We invite you to read these papers and consider Healthcare for your next manuscript submission. To learn more about our journal and submit your research, please visit the following link: https://www.mdpi.com/journal/healthcare.

Healthcare Editorial Office