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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Spotlight on Bocavirus and Other Parvoviruses, and Overlooked Respiratory Viruses

edited by

Suncanica Ljubin‐Sternak

and

Tatjana Vilibic-Cavlek

submission deadline 30 Aug 2026 | 4 articles | Viewed by 5007 | Submission Open

Keywords: bocavirus; Parvovirus B19; canine parvovirus; porcine parvovirus; metapneumovirus; rhinovirus

(This special issue belongs to the Section Animal Viruses)

Porcine Epidemic Diarrhea Virus (PEDV): A Persistent Threat to the Global Swine Industry

edited by

Ke Liu

submission deadline 31 Aug 2026 | 4 articles | Viewed by 8301 | Submission Open

Keywords: porcine epidemic diarrhea virus; global epidemiology; economic loss; vaccines and drugs; molecular mechanism; transmission and pathogenic mechanisms

(This special issue belongs to the Section Animal Viruses)

Long-Acting Antiretrovirals

edited by Camilla Muccini and Antonella Castagna

submission deadline 31 Aug 2026 | 3 articles | Viewed by 7235 | Submission Open

Keywords: HIV infection; HIV prevention; long-acting; antiretroviral therapy; clinical studies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Polyomavirus

edited by

Sunnie R. Thompson

and Patrick S. Moore

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5800 | Submission Open

Keywords: virus–host interactions; viral life cycle; viral replication; pathogenesis; phylogeny; structure; transcription; packaging; trafficking; persistence; re-arrangements; gene regulation; reactivation; miRNA; viral immune evasion; vaccines

(This special issue belongs to the Section Animal Viruses)

Pathogenesis and Persistence in Flavivirus Infections: Mechanisms, Biomarkers, and Clinical Implications

edited by

Aleksandra Drelich

and

Barbara Judy

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3876 | Submission Open

Keywords: tropical infectious diseases; flaviviruses; co-infection; cross-reactivity; long-term sequelae; neurological symptoms; autoimmunity; pathogenesis; molecular virology; diagnosis; biomarkers

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advancing Understanding of Filoviruses

edited by John Misasi and

Adam Hume

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3810 | Submission Open

Keywords: filoviruses; Ebola virus; Marburg virus; Sudan virus; Tai Forest virus; Bundibugyo virus; Reston virus; Lloviu virus; Bombali virus; Mengla virus; Dehong virus

(This special issue belongs to the Section Animal Viruses)

Mosquito-Borne Encephalitis Viruses: 2nd Edition

edited by

Megan Lloyd

and

Allison Imrie

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3173 | Submission Open

Keywords: mosquito-borne arboviruses; encephalitic togaviruses; encephalitic flaviviruses; encephalitic bunyaviruses; mosquito vectors; laboratory diagnostics; one health approaches to arbovirus ecology; arbovirus surveillance; vaccines to encephalitic arboviruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Hepatitis Viruses: Detection, Diagnosis and Treatment

edited by

Daryl Lau

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3140 | Submission Open

Keywords: molecular virology; virus–host interactions; epidemiology; novel biomarkers and therapy; HBV; HCV; HDV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Japanese Encephalitis Virus and Other Closely Related Clinically Important Orthoflaviviruses—a Persistent Threat to Public and Animal Health

edited by

Ke Liu

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3061 | Submission Open

Keywords: Japanese encephalitis virus; mosquito-borne; orthoflaviviruses; public and animal health; transmission; infection; host

(This special issue belongs to the Section General Virology)

Contribution of the Host Cell Integrated Stress Response (ISR) to Immunopathogenesis of Human RNA Viral Infections

edited by

Qiyi Tang

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3036 | Submission Open

Keywords: RNA viruses; immunopathogenesis; unfolded protein response; organelle stress; innate immunity

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Arboviruses and Climate, 2nd Edition

edited by José Lourenço and

Marta Giovanetti

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2228 | Submission Open

Keywords: arbovirus; climate; climate change; arthropods; vectors; epidemiology; evolution; ecology; public health

(This special issue belongs to the Section Invertebrate Viruses)

Insights into Feline Viruses: Molecular, Structural, Pathogenic, and Clinical Aspects

edited by

Barbara Di Martino

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1529 | Submission Open

Keywords: cats; feline viruses; emerging viruses; molecular virology; pathogenesis; clinical virology; molecular and serological diagnostics; metagenomics; therapeutic and control strategies; One Health

(This special issue belongs to the Section Animal Viruses)

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus: 2nd Edition

edited by Tongqing An and Xingyang Cui

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1354 | Submission Open

Keywords: PRRSV; genetic evolution; replication regulation; immunological or pathogenic mechanism; vaccine development; prevention and control

(This special issue belongs to the Section Animal Viruses)

Rotaviruses and Rotavirus Vaccines: 2nd Edition

edited by

Lijuan Yuan

and

Viviana Parreño

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1247 | Submission Open

Keywords: rotaviruses; molecular biology; reverse genetics; molecular epidemiology; vaccine development; human intestinal organoid models

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virus-Mediated Genome Editing in Plants

edited by

Jeanmarie Verchot

submission deadline 31 Aug 2026 | Viewed by 386 | Submission Open

Keywords: genetic vectors; viral vectors; gene editing; genetically modified plants; genetically modified insects; CRISPR-Cas systems

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Therapeutic Antibodies in HIV

edited by

Pradeep Uchil

and

Jonathan Richard

submission deadline 31 Aug 2026 | Viewed by 380 | Submission Open

Keywords: HIV-1; therapeutic antibodies; Fc-effector functions; broadly neutralizing antibodies; non-neutralizing antibodies; CD4 mimetics; Env conformation; antibody-based CAR T cells; epitope location; ADCC; ADCP; antibody engineering; HIV-1 reservoir clearance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Extracellular Vesicles in Viral Pathogenesis and Therapy

edited by

Fatah Kashanchi

and

Shilpa Buch

submission deadline 31 Aug 2026 | Viewed by 358 | Submission Open

Keywords: extracellular vesicles; viral infection; host–pathogen interaction; intercellular communication; immune evasion

(This special issue belongs to the Section General Virology)

Virus Discovery: Innovative Approaches to Detection and Characterization of Emerging Viruses

edited by

Steve Wylie

submission deadline 31 Aug 2026 | Viewed by 357 | Submission Open

Keywords: virus detection; virus assay; emerging viruses; virus threats; cryptic viruses

(This special issue belongs to the Section General Virology)

Seed-Borne and Seed-Transmitted Virus

edited by Qinsheng Gu

submission deadline 31 Aug 2026 | Viewed by 319 | Submission Open

Keywords: seed-borne virus; seed-transmitted virus; management; detection

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Baculovirus as Vaccine Vectors, RNA Interference Mediators, and Gene Delivery Vectors: 2nd Edition

edited by

Hung-Jen Liu

submission deadline 31 Aug 2026 | Viewed by 317 | Submission Open

Keywords: baculovirus; vaccine vectors; subunit vaccine; baculovirus display vectors; RNA interference mediators; gene delivery vectors

(This special issue belongs to the Section Invertebrate Viruses)

Mechanisms of Herpesvirus Resistance

edited by

Graciela Andrei

submission deadline 1 Sep 2026 | 3 articles | Viewed by 8218 | Submission Open

Keywords: human herpesviruses; cytomegalovirus; drug resistance; antiviral agents; immunocompromised host; novel anti-herpesvirus therapies; DNA polymerase; terminase

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Hepatitis B Virus—Mechanisms of Persistence and Progress Towards a Cure

edited by

Qiong Zhao

and

Yongzhen Liu

submission deadline 16 Sep 2026 | Viewed by 434 | Submission Open

Keywords: hepatitis B virus (HBV); animal models; viral–host interactions; immune responses; pathogenesis; antivirals; HBV persistence

(This special issue belongs to the Section Human Virology and Viral Diseases)

Coronaviruses Pathogenesis, Immunity, and Antivirals (2nd Edition)

edited by

Wentao Li

and Fei Yu

submission deadline 30 Sep 2026 | 13 articles | Viewed by 24771 | Submission Open

Keywords: coronavirus; pathogenesis; molecular; vaccines; evolution; immunity; antivirals

(This special issue belongs to the Section Coronaviruses)

Viral Diseases of Domestic Animals

edited by

Scott P. Kenney

submission deadline 30 Sep 2026 | 7 articles | Viewed by 15297 | Submission Open

Keywords: viral diseases; emerging infections; domestic animals; epidemiology; pathogenesis

(This special issue belongs to the Section Animal Viruses)

Viruses in the Reproductive Tract

edited by

Mimi Ghosh

Raina Nakova Fichorova

and Christina Farr

submission deadline 30 Sep 2026 | 8 articles | Viewed by 10257 | Submission Open

Keywords: reproductive tract virome; viruses in pregnancy; virus infections and adverse fetal health; virus-associated malignancies of the reproductive tract; immune response to viruses of the reproductive tract; antiviral biomarkers; antiviral vaccines and drugs; hormonal regulation of virus infections

(This special issue belongs to the Section General Virology)

Herpesviruses and Associated Diseases, 2nd Edition

edited by

Sherif T.S. Hassan

submission deadline 30 Sep 2026 | 4 articles | Viewed by 7793 | Submission Open

Keywords: human herpesviruses; animal herpesviruses; viral latency and reactivation; immune evasion strategies; herpesvirus–host interactions; herpesvirus biology and pathogenesis; herpesvirus diagnosis; environmental factors; herpesvirus-associated diseases; prevention and treatment strategies; antiviral therapies; vaccine development

(This special issue belongs to the Section Human Virology and Viral Diseases)

Wastewater-Based Epidemiology and Viral Surveillance

edited by

Elisabetta Carraro

Cristina Pignata

and

Silvia Bonetta

submission deadline 30 Sep 2026 | 5 articles | Viewed by 7456 | Submission Open

Keywords: wastewater‐based epidemiology; WBE; viral surveillance; virus shedding; sewage; viral dynamics

(This special issue belongs to the Section Human Virology and Viral Diseases)

Pestivirus 2026

edited by

Benjamin J. Lamp

and Christiane M. Riedel

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6426 | Submission Open

Keywords: pestiviruses; classical swine fever virus; bovine viral diarrhea virus; BVDV-1; BVDV-2; CSF

(This special issue belongs to the Section Animal Viruses)

Antigenic Drift in Respiratory Viruses

edited by

Gabriel Gonzalez

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6196 | Submission Open

Keywords: respiratory viruses; virus diversity; viral recombination; reassortment; zoonotic viruses; wastewater pathogen surveillance; viral sequencing; virus evolutionary characterization; animal viruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Progress and Prospects in Oncolytic Virotherapy 2025–2026

edited by

Arianna Calistri

and

Sandra Tuyaerts

submission deadline 30 Sep 2026 | 2 articles | Viewed by 5862 | Submission Open

Keywords: oncovirotherapy; chemotherapy; preclinical studies; clinical trials; combinatory strategy; safety profile; therapeutic efficacy; immunotherapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Cross-Pathogen Insights into Infectious Diseases: From Biomarkers to Burden and Therapeutic Strategies of Viral Pathogens

edited by

Karolina Akinosoglou

submission deadline 30 Sep 2026 | 4 articles | Viewed by 5531 | Submission Open

Keywords: cross-pathogen perspective; biomarkers; viral sepsis; therapeutic landscape

(This special issue belongs to the Section General Virology)

Nucleocytoviricota

edited by Natalya Yutin

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5121 | Submission Open

Keywords: Nucleocytoviricota; giant viruses; virophages; host–virus (-virophage) interactions; virion structure; viral ecology; diversity and classification; evolution of Nucleocytoviricota

(This special issue belongs to the Section General Virology)

The Structure and Function of Flavivirus Genes and Proteins

edited by

Tadahisa Teramoto

and Kay Choi

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4890 | Submission Open

Keywords: flavivirus; structural protein; non-structural protein; 5'UTR; 3'UTR

(This special issue belongs to the Section General Virology)

Coronavirus Therapy: Antiviral Drugs and Anti-Inflammatory Immunopharmacology

edited by

Chengyuan Liang

Lei Tian

and

Mengzhou Wang

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3260 | Submission Open

Keywords: coronavirus therapeutics; antiviral target; host-directed antivirals; immunomodulation; diagnostics; prevention; antiviral resistance; AI-driven drug discovery

(This special issue belongs to the Section Coronaviruses)

Veterinary Virology: Unraveling Host–Pathogen Interactions for Animal Health

edited by

Muhammad Jasim Uddin

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3012 | Submission Open

Keywords: veterinary virology; host–pathogen interactions; viral replication and immune evasion; zoonotic viruses; One Health; vaccine and therapeutic development; molecular virology and genomics; emerging and re-emerging viral pathogens or diseases; animal health and welfare; high-throughput or deep sequencing; outbreak prevention and control; food security

(This special issue belongs to the Section Animal Viruses)

The Entry and Fusion of Enveloped Virus

edited by

Tsutomu Murakami

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2923 | Submission Open

Keywords: enveloped virus; entry; attachment; virus binding; membrane fusion; internalization; endocytosis; uncoating; intracellular trafficking; nuclear import; receptor; carbohydrates; antiviral; neutralizing antibody; vaccine

(This special issue belongs to the Section General Virology)

Coronaviruses: Variants, Antivirals, and Vaccination

edited by

Cheng-Wen Lin

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2396 | Submission Open

Keywords: coronavirus variants; SARS-CoV-2 evolution; antivirals; vaccination; immune response; global health; viral pathogenesis; public health preparedness; host genomics; monoclonal antibodies

(This special issue belongs to the Section Coronaviruses)

Unraveling Human Herpesviruses: From Molecular Mechanisms to Antiviral Approaches

edited by

Christopher B. Whitehurst

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2320 | Submission Open

Keywords: human herpesviruses; post-translational modifications; epigenetics; cancer; molecular mechanisms; antivirals; protein interactions

(This special issue belongs to the Section Human Virology and Viral Diseases)

3D Models in Viral Pathogenesis

edited by

David C. Bloom

Leonardo D'Aiuto

and Elizabeth Fortunato

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1958 | Submission Open

Keywords: organoids; viral pathogenesis; mini-brains; 3D culture; viruses; in vitro models

(This special issue belongs to the Section General Virology)

Common Pathogenic Mechanisms of Plant Viruses

edited by

Yen-Wen Kuo

and Jun Jiang

submission deadline 30 Sep 2026 | 1 articles | Viewed by 689 | Submission Open

Keywords: plant viruses; viral pathogenicity; host–virus interactions; viral replication; virus movement; suppression of RNA silencing; plant immunity; conserved mechanisms; molecular virology

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Innate Immune Sensing of Viruses

edited by Zi Li

submission deadline 30 Sep 2026 | Viewed by 476 | Submission Open

Keywords: innate immunity; viral sensing; pattern recognition receptors (PRRs); damage-associated molecular patterns (DAMPs); interferon response; inflammasome activation; viral immune evasion; antiviral defense; trained immunity; immunometabolism

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Immune Evasion and Viral Carcinogenesis

edited by

Christoph Weigel

and Tuan L. Phan

submission deadline 30 Sep 2026 | Viewed by 398 | Submission Open

Keywords: viral oncogenesis; viral carcinogenesis; immune evasion; immune surveillance; oncogenic viruses; immunosuppression; host-pathogen interactions

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Alphavirus Structural Dynamics and Host–Cell Entry: Structure-Guided Therapeutic and Vaccine Development

edited by

Qibin Geng

submission deadline 30 Sep 2026 | Viewed by 372 | Submission Open

Keywords: alphavirus virion architecture; cryo-EM/cryo-ET; E1/E2 glycoproteins; receptor recognition and tropism; membrane fusion; structural dynamics; nsP replication complexes; structure-guided antiviral discovery; neutralizing antibodies/nanobodies; alphavirus-induced arthritis

(This special issue belongs to the Section Animal Viruses)

Neuropathogenesis in HIV Infection: Mechanisms and Reservoirs

edited by Rebecca T. Veenhuis

submission deadline 30 Sep 2026 | Viewed by 359 | Submission Open

Keywords: HIV-associated neuroinflammation; HIV reservoirs; HIV-associated neuropathogenesis; HIV-associated comorbidities

(This special issue belongs to the Section Human Virology and Viral Diseases)

Re-Emergence of Yellow Fever Virus

edited by Rosemary Sang

submission deadline 30 Sep 2026 | Viewed by 331 | Submission Open

Keywords: yellow fever virus; Orthoflavivirus; mosquito-borne transmission; viral evolution; outbreak expansion; vaccination challenges; molecular epidemiology; control strategies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viruses Associated with Gastroenteritis: 2nd Edition

edited by

Celso Cunha

and

Claudia Istrate

submission deadline 30 Sep 2026 | Viewed by 331 | Submission Open

Keywords: vaccines; therapeutic approaches; virus replication; molecular epidemiology; immune response; microbiome; diagnosis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Filoviruses: Ebola and Marburg—Virus–Host Interactions: New Insights into Viral Pathogenesis and Therapeutic Advances

edited by

Asuka Nanbo

submission deadline 30 Sep 2026 | Viewed by 326 | Submission Open

Keywords: virus–host interactions; viral infection mechanisms; viral pathogenesis; therapeutic strategies; vaccine development; advanced experimental technologies

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Imaging Neurotropic Viruses

edited by

Elena Criscuolo

and

Salla Mattola

submission deadline 30 Sep 2026 | Viewed by 307 | Submission Open

Keywords: neurotropic viruses; neuroinvasion; immune evasion; host–virus interactions; neuronal models; organoids; live-cell microscopy; microfuidics

(This special issue belongs to the Section General Virology)

Plant Viruses and Their Vectors: Epidemiology, Control, and Diagnostics

edited by

Beata Hasiów-Jaroszewska

and

Matthaios M. Mathioudakis

submission deadline 30 Sep 2026 | Viewed by 266 | Submission Open

Keywords: epidemiology; diagnostics tools; virus-vector-host interactions; genetic diversity

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Zoonotic and Vector-Borne Viral Diseases: 2nd Edition

edited by

Nariman Shahhosseini

submission deadline 1 Oct 2026 | 4 articles | Viewed by 5404 | Submission Open

Keywords: vector-borne viral diseases (VBVDs); vector–host–pathogen interactions; emerging and re-emerging; zoonotic diseases; vectors or reservoirs; vaccine development, and prevention and control measures; One Health

(This special issue belongs to the Section Animal Viruses)

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