Pathogenesis and Persistence in Flavivirus Infections: Mechanisms, Biomarkers, and Clinical Implications
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 16
Special Issue Editors
Interests: coronaviruses; neutralizing antibody; flaviviridae; filoviruses; blood-brain-barrier; coagulopathy; vaccines; autoimmunity
Interests: emerging and re-emerging tropical viruses
Special Issue Information
Dear Colleagues,
Emerging and re-emerging flaviviruses—including Dengue, Zika, Yellow Fever, and West Nile viruses—remain major contributors to the global burden of tropical infectious diseases. Understanding their complex pathogenesis is essential not only for managing acute illness but also for addressing the growing recognition of long-term sequelae, such as neurological syndromes, congenital abnormalities, autoimmune complications, and chronic inflammation.
The development of these sequelae is shaped not only by the initial viral infection but also by host immune responses and, importantly, by co-infections with other flaviviruses. In regions where multiple flaviviruses co-circulate, overlapping clinical presentations and cross-reactive immune responses make accurate and timely diagnosis particularly challenging. These diagnostic uncertainties may lead to under-recognition of co-infections, obscuring their role in shaping disease trajectory and long-term outcomes.
This Special Issue focuses on the long-term impact of flaviviral infections, emphasizing research that clarifies how early viral dynamics, immune modulation, and co-infection contribute to persistent or delayed clinical manifestations. It highlights current advances in molecular virology, immunopathology, and biomarker discovery that are improving the identification, monitoring, and potential mitigation of these outcomes.
By bringing together basic, clinical, and translational research, this collection aims to advance our understanding of the full disease spectrum and support the development of more precise diagnostic and therapeutic strategies that address both the acute and chronic dimensions of flavivirus-associated disease.
Dr. Aleksandra Drelich
Dr. Barbara Judy
Guest Editors
Manuscript Submission Information
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Keywords
- tropical infectious diseases
- flaviviruses
- co-infection
- cross-reactivity
- long-term sequelae
- neurological symptoms
- autoimmunity
- pathogenesis
- molecular virology
- diagnosis
- biomarkers
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