Innate Immune Sensing of Viruses
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 199
Special Issue Editor
Interests: virus–host innate immune interactions; antiviral immunity; coronavirus replication and pathogenesis; neuroimmunology
Special Issue Information
Dear Colleagues,
The innate immune system constitutes the first line of defense against viral infections, relying on pattern recognition receptors (PRRs) to detect pathogen-associated molecular patterns (PAMPs). This recognition triggers potent antiviral responses, primarily through the production of type I interferons and pro-inflammatory cytokines. Importantly, virus-induced cell damage also releases host-derived damage-associated molecular patterns (DAMPs), which can amplify and modulate these innate immune signals. This synergistic or antagonistic interplay between PAMPs and DAMPs critically shapes the intensity, quality, and outcome of the antiviral response, influencing both viral control and immunopathology.
This Special Issue will highlight cutting-edge research on the molecular mechanisms of innate immune sensing of viruses. We welcome original research and reviews focusing on novel sensing pathways, the intricate crosstalk between PAMP and DAMP signaling, viral strategies to evade or manipulate these systems, and the translational implications for understanding pathogenesis and developing novel immunomodulatory therapies.
Prof. Dr. Zi Li
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Keywords
- innate immunity
- viral sensing
- pattern recognition receptors (PRRs)
- damage-associated molecular patterns (DAMPs)
- interferon response
- inflammasome activation
- viral immune evasion
- antiviral defense
- trained immunity
- immunometabolism
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