Insights into Feline Viruses: Molecular, Structural, Pathogenic, and Clinical Aspects

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1231

Editor


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Guest Editor
Department of Veterinary Medicine, University of Teramo, Località Piano D’Accio, 64100 Teramo, Italy
Interests: emerging viruses; feline viruses; viral zoonoses; molecular epidemiology; genomics; One Health
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Special Issue Information

Dear Colleagues,

Feline viruses are responsible for a wide spectrum of diseases, ranging from mild infections to severe, often fatal conditions. Recent advances in molecular diagnostics, metagenomics, and structural biology have significantly enhanced our understanding of viral diversity, evolution, and host–pathogen interactions in cats. Nevertheless, many aspects of feline viral infections, including mechanisms of virulence, immune evasion, and interspecies transmission, have yet to be fully elucidated. Intensifying the One Health perspective, efforts in the study of feline viral pathogens improve and ensure not just the health and welfare of cats but also that of susceptible endangered wild felids, also providing insights into human diseases.

The Special Issue, “Insights into Feline Viruses: Molecular, Structural, Pathogenic, and Clinical Aspects,” aims to collect original research papers, communications, case reports, and review articles addressing the identification and characterization of novel pathogens, molecular and structural insights into viral replication, pathogenesis, and clinical features, including novel and/or updated diagnostic developments and innovative therapeutic or control strategies for feline viruses.

We aim for this Special Issue to stimulate further research and collaboration in the field of feline virology within a One Health framework.

Prof. Dr. Barbara Di Martino
Guest Editor

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Keywords

  • cats
  • feline viruses
  • emerging viruses
  • molecular virology
  • pathogenesis
  • clinical virology
  • molecular and serological diagnostics
  • metagenomics
  • therapeutic and control strategies
  • One Health

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Published Papers (1 paper)

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Review

16 pages, 809 KB  
Review
Feline Rotavirus A as a Source of Spillover Infections to Humans: An In-Depth Analysis of Molecular Epidemiological Evidence
by Osamu Nakagomi and Toyoko Nakagomi
Viruses 2026, 18(2), 207; https://doi.org/10.3390/v18020207 - 5 Feb 2026
Cited by 1 | Viewed by 988
Abstract
Rotavirus A (RVA) is a leading cause of severe diarrhoea in children, and interspecies transmission significantly drives the genomic diversity of human RVAs. Cats represent a key host species, requiring in-depth analysis regarding RVA transmission to humans. This review evaluated the literature on [...] Read more.
Rotavirus A (RVA) is a leading cause of severe diarrhoea in children, and interspecies transmission significantly drives the genomic diversity of human RVAs. Cats represent a key host species, requiring in-depth analysis regarding RVA transmission to humans. This review evaluated the literature on the complex genotype constellations of feline RVAs in relation to relevant canine and human RVAs to define the role of feline RVAs in the evolutionary history of human strains. The review traces the methodological shift from genogrouping by RNA-RNA hybridisation to the current genotype constellation system enabled by whole-genome sequencing. While early methods identified a shared genomic closeness between human AU-1 and feline FRV-1, whole-genome sequencing indicated that several human RVA strains, including AU-1, HCR3A, and Ro1845, likely resulted from direct transmission of feline/canine strains, due to shared genotype constellations and high sequence identity with animal strains like feline FRV-1, Cat97 and canine CU-1. Evidence of reassortment—such as the emergence of G1P[9] and G9P[9] strains after the feline-derived G3P[9] crossed into the human population—suggests these feline-like strains have successfully overcome the host-species barrier and are capable of onward human-to-human transmission, not just dead-end spillover events. However, definitive confirmation of sustained transmission or contemporary spillover requires stringent phylogenetic criteria: multiple human strains with >99% identical sequences in a monophyletic lineage for sustained transmission, or an identical human–feline pair across all genome segments for contemporary spillover. Confirming the status of the AU-1-like constellation as a third, low-frequency human RVA type requires future studies applying these strict criteria. Full article
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