Baculovirus as Vaccine Vectors, RNA Interference Mediators, and Gene Delivery Vectors: 2nd Edition

Dear Colleagues,

Baculoviruses are DNA viruses capable of infecting more than 600 insects. Among these, Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is the best characterized and most extensively utilized. Baculovirus infects insects in nature and is non-pathogenic toward humans. Baculovirus is an attractive and convenient tool for use as a vaccine expression/delivery vector and has been extensively utilized to produce recombinant proteins in insect cells. In addition to insect cells, baculovirus is capable of transducing a broad range of animal cells. Due to its biosafety, significant cloning capacity, low cytotoxicity, and non-replication nature in transduced cells, its ease of manipulation and production, and its protein expression/display, baculovirus has been used in RNA interference mediators and gene delivery vectors in a wide variety of applications. This Special Issue will highlight applications of baculoviruses as vaccine vectors in producing vaccines and emphasize the use of baculoviruses as RNA interference mediators and gene delivery vectors.

Prof. Dr. Hung-Jen Liu
Guest Editor

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