Rotaviruses and Rotavirus Vaccines: 2nd Edition

Dear Colleagues,

Rotaviruses remain a major cause of acute gastroenteritis in infants, young children, and the young of mammalian and avian hosts. Although widespread vaccination programs have significantly reduced the disease burden, vaccine performance continues to vary geographically, with the lowest efficacy observed in the low- and middle-income countries where the need for prevention is greatest. In addition, novel and reassortant strains continue to emerge from animal reservoirs, highlighting the dynamic nature of rotavirus evolution and the importance of ongoing surveillance. Since the publication of the first edition of this Special Issue of Viruses, technological advances—including reverse genetics, human intestinal enteroid and organoid models, high-resolution structural virology, and systems immunology—have provided powerful tools to assess viral replication, immune evasion, and host–virus interactions. This second edition will highlight new frontiers, including the durability of vaccine-induced protection, vaccine coverage, the interference of maternal passive antibodies and the development of passive immune strategies for animals and humans, microbiome and environmental influences, innovative vaccine platforms and therapeutics, zoonotic and evolutionary dynamics, and next-generation approaches to diagnostics and surveillance. Together, this Special Issue’s contributions will guide progress toward achieving durable and equitable control of rotavirus disease worldwide.

Prof. Dr. Lijuan Yuan
Dr. Viviana Parreño
Guest Editors

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