Special Issues

Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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SARS-CoV-2 Neutralizing Antibodies, 3rd Edition
edited by Youchun Wang
submission deadline 31 Jan 2026 | 3 articles | Viewed by 4819 | Submission Open
Keywords: SARS-CoV-2; neutralizing antibodies; neutralization assays; standards; monoclonal antibodies; vaccines; viral variants
(This special issue belongs to the Section Coronaviruses)
Role of Lectins in Viral Infections and Antiviral Intervention
edited by Yuan Guo
submission deadline 31 Jan 2026 | 3 articles | Viewed by 4444 | Submission Open
Keywords: lectin– glycan interaction; membrane fusion; immune evasion; multivalency; glycan conjugates; lectin constructs; antivirals
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Translational Research in Virology submission deadline 31 Jan 2026 | 2 articles | Viewed by 3923 | Submission Open
Keywords: vaccines; antiviral drugs; monoclonal antibodies; viral vectors; self-amplifying RNA; clinical trials; translational medicine; proteomic analysis; antiviral resistance; bioinformatics; structural virology; immune escape mechanisms; viral evolution; diagnostic virology; high-throughput screening; nanotechnology in virology; viral assembly and disassembly; host-pathogen interactions; emerging viral infections
(This special issue belongs to the Section Human Virology and Viral Diseases)
Viral Infection in Airway Epithelial Cells
edited by Camille Ehré and Raymond J. Pickles
submission deadline 31 Jan 2026 | 2 articles | Viewed by 3758 | Submission Open
Keywords: respiratory viral infections; airway epithelial cells; virus– host interactions; viral pathogenesis; immune responses; Influenza viruses; respiratory syncytial virus (rsv); coronaviruses; SARS-CoV-2; respiratory tract
(This special issue belongs to the Section Animal Viruses)
Emerging and Re-Emerging Plant Viruses and Vector Complexes: Advances in Characterization, Surveillance, and Mitigation submission deadline 31 Jan 2026 | 3 articles | Viewed by 3326 | Submission Open
Keywords: climate change and emerging/re-emerging virus threats; impact of virus evolution on the emerging/re-emerging virus diseases; innovative virus detection and surveillance methods; plant defense and virus resistance mechanisms responding to new outbreaks; plant defenses that respond to virus infection in lieu of extreme climate circumstances; plant virus diseases; plant– virus and/or plant– vector interactions; including tritrophic interactions; plant/crop resistance to viruses and/or arthropod vectors; strategies for management of viruses and vectors; virus– vector interactions; specific scenarios of emerging and reemerging viruses:; insect or mite-transmitted viruses of plants; seed-borne or seed-transmitted viruses of plants; soil-borne or soil-transmitted viruses; viruses infecting nursery crops and trees; water-borne or water-transmitted plant viruses
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
HIV and Drugs of Abuse, 4th Edition submission deadline 31 Jan 2026 | 2 articles | Viewed by 3099 | Submission Open
Keywords: substance use disorders; HIV; HAND; methamphetamine
(This special issue belongs to the Section Human Virology and Viral Diseases)
Rift Valley Fever Virus: New Insights into a One Health Archetype
edited by , Juliette Lewis and Brian H. Bird
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2861 | Submission Open
Keywords: One Health; emerging infectious diseases; mosquito; bunyavirus; arbovirus; medical entomology; medical countermeasures; livestock
(This special issue belongs to the Section Animal Viruses)
Cellular Immune Response to Hepatitis Viruses submission deadline 31 Jan 2026 | 1 articles | Viewed by 2675 | Submission Open
Keywords: viral hepatitis; viral/host interactions; immune response; immune evasion; immunopathogenesis; immunomodulatory therapy; pre-clinical models
(This special issue belongs to the Section Human Virology and Viral Diseases)
Long-Acting Antiretrovirals
edited by Camilla Muccini and Antonella Castagna
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2654 | Submission Open
Keywords: HIV infection; HIV prevention; long-acting; antiretroviral therapy; clinical studies
(This special issue belongs to the Section Human Virology and Viral Diseases)
Emerging Controversies and Advances in Neurovirology submission deadline 31 Jan 2026 | 2 articles | Viewed by 2477 | Submission Open
Keywords: neurovirology; viral encephalitis; persistent viral infection; neuroinflammation; viral latency; oncolytic viruses; brain tumors; neurodegeneration; SARS-CoV-2; long COVID; zoonotic viruses; neural organoids; microglia activation; virus– host interactions; viral neuropathogenesis; central nervous system infections; herpesviruses; immune-mediated neurodegeneration; viral reactivation; ethical issues in neurovirology
(This special issue belongs to the Section Human Virology and Viral Diseases)
Bluetongue, Epizootic Haemorrhagic Disease, and Other Emerging Orbiviruses, 2nd Edition
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2387 | Submission Open
Keywords: bluetongue; epizootic haemorrhagic disease; orbiviruses; African horse sickness; vector-borne diseases
(This special issue belongs to the Section Animal Viruses)
Host Defense, Viruses and Cell Death Pathways submission deadline 31 Jan 2026 | 1 articles | Viewed by 1385 | Submission Open
Keywords: virus– host; programmed cell death; apoptosis; necroptosis; pyroptosis; viral factors and cell death effector interplay; oncolytic
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Viruses in the Reproductive Tract
edited by , and Christina Farr
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1138 | Submission Open
Keywords: reproductive tract virome; viruses in pregnancy; virus infections and adverse fetal health; virus-associated malignancies of the reproductive tract; immune response to viruses of the reproductive tract; antiviral biomarkers; antiviral vaccines and drugs; hormonal regulation of virus infections
(This special issue belongs to the Section General Virology)
Bornaviruses 2025: News, Gaps and Future Directions submission deadline 31 Jan 2026 | Viewed by 548 | Submission Open
Keywords: bornaviruses; zoonotic; epidemiology; transmission; molecular infection mechanisms; pathogenesis; antiviral
(This special issue belongs to the Section Animal Viruses)
Research Progress on Porcine Reproductive and Respiratory Syndrome Virus: 2nd Edition
edited by Tongqing An and Xingyang Cui
submission deadline 31 Jan 2026 | Viewed by 282 | Submission Open
Keywords: PRRSV; genetic evolution; replication regulation; immunological or pathogenic mechanism; vaccine development; prevention and control
(This special issue belongs to the Section Animal Viruses)
Viral Dynamics in Aquatic Environments: Pathogens, Transmission and Impacts submission deadline 31 Jan 2026 | Viewed by 228 | Submission Open
Keywords: waterborne viruses; emerging pathogens; human and animal health; viral dynamics; viral ecology; bacteriophages; transmission
(This special issue belongs to the Section General Virology)
Congenital Cytomegalovirus Infection, 3rd Edition
edited by
submission deadline 31 Jan 2026 | Viewed by 212 | Submission Open
Keywords: primary cytomegalovirus infection; pregnancy; CMV screening; hyperimmune globulin; valaciclovir
(This special issue belongs to the Section Human Virology and Viral Diseases)
Antiviral Drugs and Biologics Targeting HIV: Drug Resistance to Newer Treatment and Pre-Exposure Prophylaxis (PrEP) Options: 2nd Edition
edited by
submission deadline 31 Jan 2026 | Viewed by 165 | Submission Open
Keywords: HIV; antiretroviral therapy (ART); pre-exposure prophylaxis (PrEP); antiviral drugs; drug resistance
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Baculovirus as Vaccine Vectors, RNA Interference Mediators, and Gene Delivery Vectors: 2nd Edition
edited by
submission deadline 31 Jan 2026 | Viewed by 109 | Submission Open
Keywords: baculovirus; vaccine vectors; subunit vaccine; baculovirus display vectors; RNA interference mediators; gene delivery vectors
(This special issue belongs to the Section Invertebrate Viruses)
Insect-Specific Viruses and Biological Control of Arboviruses submission deadline 6 Feb 2026 | Viewed by 354 | Submission Open
Keywords: insect-specific virus; mosquito-specific virus; arbovirus; evolution; vaccine; biological control; interference
(This special issue belongs to the Section Invertebrate Viruses)
Infectious Disease Epidemiology: Current Updates and Perspectives submission deadline 10 Feb 2026 | Viewed by 175 | Submission Open
Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments
(This special issue belongs to the Section General Virology)
Role of Bacteriophage in Intestine Microbial Communities
edited by Yi Duan
submission deadline 15 Feb 2026 | 1 articles | Viewed by 1373 | Submission Open
Keywords: bacteriophage; intestinal microbiome; virome; microbial homeostasis; phage therapy; gut ecology; intestinal dysbiosis; antimicrobial resistance; microbiome engineering; host– microbe interactions
(This special issue belongs to the Section Bacterial Viruses)
15-Year Anniversary of Viruses submission deadline 28 Feb 2026 | 16 articles | Viewed by 33023 | Submission Open
Keywords: diversity; innovation; and impact of modern virology research; virology across all domains; Viruses  fifteenth year anniversary  
(This special issue belongs to the Section General Virology)
Evolution and Adaptation of Avian Viruses submission deadline 28 Feb 2026 | 7 articles | Viewed by 14781 | Submission Open
Keywords: virus; poultry; evolution; genetics; diagnosis; host; epidemiology; control; vaccine
(This special issue belongs to the Section Animal Viruses)
PANoptosis in Viral Infection submission deadline 28 Feb 2026 | 4 articles | Viewed by 13912 | Submission Open
Keywords: • Viruses• Inflammation• PANoptosis• PANoptosome
(This special issue belongs to the Section General Virology)
Bovine Viral Diarrhea Viruses and Other Pestiviruses
edited by
submission deadline 28 Feb 2026 | 9 articles | Viewed by 9777 | Submission Open
Keywords: epidemiological survey; prevalence; seroprevalence; bovine viral diarrhoea; mucosal disease; neutralizing antibodies; taxonomy; antiviral drugs; vaccines; species and subgenotypes; wild animal
(This special issue belongs to the Section Animal Viruses)
Viral Diseases of Domestic Animals
edited by
submission deadline 28 Feb 2026 | 6 articles | Viewed by 9606 | Submission Open
Keywords: viral diseases; emerging infections; domestic animals; epidemiology; pathogenesis
(This special issue belongs to the Section Animal Viruses)
Virus-Host Protein Interactions
edited by
submission deadline 28 Feb 2026 | 6 articles | Viewed by 8382 | Submission Open
Keywords: protein– protein interactions; antiviral drug discovery; protein target inhibitors
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Diversity and Evolution of Viruses in Ecosystem 2025
edited by
submission deadline 28 Feb 2026 | 3 articles | Viewed by 5458 | Submission Open
Keywords: environmental virology; viral metagenomics; viral metatranscriptomics; phage genomics; virus evolution and phylogeny
(This special issue belongs to the Section General Virology)
Bacteriophage Diversity, 2nd Edition
edited by Bert Ely
submission deadline 28 Feb 2026 | 3 articles | Viewed by 3773 | Submission Open
Keywords: bacteriophages phage; diversity genome; evolution; new genera; phage-host interactions
(This special issue belongs to the Section Bacterial Viruses)
Veterinary Virology: Unraveling Host–Pathogen Interactions for Animal Health submission deadline 28 Feb 2026 | 2 articles | Viewed by 1636 | Submission Open
Keywords: veterinary virology; host– pathogen interactions; viral replication and immune evasion; zoonotic viruses; One Health; vaccine and therapeutic development; molecular virology and genomics; emerging and re-emerging viral pathogens or diseases; animal health and welfare; high-throughput or deep sequencing; outbreak prevention and control; food security
(This special issue belongs to the Section Animal Viruses)
Pharmacology of Antiviral Drugs, 2nd Edition
edited by
submission deadline 28 Feb 2026 | 2 articles | Viewed by 1578 | Submission Open
Keywords: pharmacology; clinical pharmacology; antiviral therapy; antiviral prophylaxis; human viruses; animal viruses; pharmacokinetics; pharmacodynamics; drug resistance
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
One Health Approach: Tackling the Spillover of Zoonotic Viruses from Wildlife to Humans submission deadline 28 Feb 2026 | 1 articles | Viewed by 1508 | Submission Open
Keywords: One Health; spillover; viruses; emerging viruses
(This special issue belongs to the Section Animal Viruses)
Advancing Understanding of Filoviruses
edited by John Misasi and
submission deadline 28 Feb 2026 | 1 articles | Viewed by 951 | Submission Open
Keywords: filoviruses; Ebola virus; Marburg virus; Sudan virus; Tai Forest virus; Bundibugyo virus; Reston virus; Lloviu virus; Bombali virus; Mengla virus; Dehong virus
(This special issue belongs to the Section Animal Viruses)
Nuclear Architecture in Viral Infection
edited by Veronica Sanchez and Elizabeth White
submission deadline 28 Feb 2026 | 1 articles | Viewed by 896 | Submission Open
Keywords: nuclear architecture; viral transcription; viral replication; viral assembly
(This special issue belongs to the Section General Virology)
Foot-and-Mouth Disease Virus submission deadline 28 Feb 2026 | 1 articles | Viewed by 610 | Submission Open
Keywords: foot-and-mouth disease; foot-and-mouth disease virus; hoof-and-mouth disease; FMD; FMD virus; foot-and-mouth disease vaccines
(This special issue belongs to the Section Animal Viruses)
Synanthropy and Zoonotic Viral Spillover submission deadline 28 Feb 2026 | Viewed by 556 | Submission Open
Keywords: zoonoses; synanthropic interactions; virus; emergence; spillover
(This special issue belongs to the Section Animal Viruses)
Endogenous Retrovirus Proteins and Their Functions, 2nd Edition
edited by
submission deadline 28 Feb 2026 | Viewed by 487 | Submission Open
Keywords: endogenous retrovirus; ERV envelope protein; receptor; cell fusion; cancer; pre-eclampsia; obstetric disorder; diagnosis; evolutionary conservation; gene regulation
(This special issue belongs to the Section Human Virology and Viral Diseases)
Innovative Prophylactic and Therapeutics for the Treatment of Coronavirus Infection
edited by and Jun-Gyu Park
submission deadline 28 Feb 2026 | Viewed by 350 | Submission Open
Keywords: prophylactic; therapeutics; SARS-CoV-2; viral variants; antivirals
(This special issue belongs to the Section Coronaviruses)
Pathogenesis and Persistence in Flavivirus Infections: Mechanisms, Biomarkers, and Clinical Implications submission deadline 28 Feb 2026 | Viewed by 177 | Submission Open
Keywords: tropical infectious diseases; flaviviruses; co-infection; cross-reactivity; long-term sequelae; neurological symptoms; autoimmunity; pathogenesis; molecular virology; diagnosis; biomarkers
(This special issue belongs to the Section Human Virology and Viral Diseases)
HIV Accessory Proteins
edited by
submission deadline 28 Feb 2026 | Viewed by 165 | Submission Open
Keywords: accessory proteins; cellular interactions; drug design; liquid– liquid phase separations; molecular condensate; HIV; novel accessory proteins from other viruses
(This special issue belongs to the Section General Virology)
Functional RNAs in Virology submission deadline 28 Feb 2026 | Viewed by 163 | Submission Open
Keywords: functional RNA elements; viral RNA structure; cis-acting RNA motifs; non-coding RNAs; RNA– protein interactions; RNA-based regulation; RNA virus biology; structured RNA; computational RNA analysis; virus bioinformatics
(This special issue belongs to the Section General Virology)
Food-Associated and Foodborne Viruses: A Food Safety Concern or Tool?
edited by , Daofeng Liu and
submission deadline 28 Feb 2026 | Viewed by 134 | Submission Open
Keywords: foodborne viruses; norovirus epidemiology; viral zoonoses; phage biocontrol; food viromics; virus detection technologies
(This special issue belongs to the Section General Virology)
Chronic Infection by Oncogenic Viruses: 2nd Edition
edited by
submission deadline 28 Feb 2026 | Viewed by 128 | Submission Open
Keywords: virus transmission; virus replication; virus pathogenesis; virus latency; virus– host interactions; antiviral immune responses; virus-induced cellular transformation; antiviral drugs and vaccines
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Viruses of Plant Pathogens and Pests
edited by Alexander V. Karasev
submission deadline 28 Feb 2026 | Viewed by 112 | Submission Open
Keywords: plant virus; virus diversity; transmission; genetic diversity; evolution; virus– host interactions
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Mpox (Monkeypox): From Neglected Tropical Disease to Emerging Global Pathogen
edited by , and Patrick Katoto
submission deadline 1 Mar 2026 | 16 articles | Viewed by 32330 | Submission Open
Keywords: monkeypox; mpox; monkeypox virus; mpxv; poxvirus; Poxviridae; Africa; DR Congo; outbreak; epidemic; stillbirth; sexual transmission; vaccination; emerging infection
(This special issue belongs to the Section Human Virology and Viral Diseases)
Spumaretroviruses: Research and Applications
edited by , , , Martin Löchelt and Paul Lesbats
submission deadline 1 Mar 2026 | 2 articles | Viewed by 2950 | Submission Open
Keywords: ancient retroviruses; antivirals; complex retroviruses; endogenous elements; foamy viruses; foamy virus-host interactions; foamy virus prevalence; foamy virus vectors; immune responses; molecular biology and replication; natural infections; nonhuman primates and non-primates; restriction factors spumaretroviruses; structural biology; taxonomy; viral proteins; virus detection assays; zoonoses
(This special issue belongs to the Section Animal Viruses)
Nucleocytoviricota
edited by Natalya Yutin
submission deadline 1 Mar 2026 | Viewed by 161 | Submission Open
Keywords: Nucleocytoviricota; giant viruses; virophages; host– virus (-virophage) interactions; virion structure; viral ecology; diversity and classification; evolution of Nucleocytoviricota Planned Paper  Title: Unveiling Intra-Clonal Diversity of Monkeypox Virus from Brazil’ s First Outbreak Wave Abstract: Orthopoxvirus monkeypox (MPXV) is an emerging zoonotic pathogen responsible for mpox; a disease characterized by smallpox-like symptoms; typically mild but occasionally fatal. The largest recorded global outbreak began in May 2022; with over 162; 000 cases across 140 countries (WHO; September 2025). Herein; we have analyzed a skin lesion sample from a male patient (June 2022); molecularly diagnosed as MPXV. The virus was isolated; purified; and characterized ultrastructurally; phenotypically; and genomically. In this study; three viral clones were obtained following phenotypic evaluation of MPXV lysis plaque characteristics over a three-course infection in BSC-40 cells. Unlike the vaccinia virus Western Reserve (VACV-WR) strain; MPXV clones did not form comet-like structures; suggesting reduced EEV particle release; which is associated with viral dissemination. Whole-genome sequencing and assembly identified subtle differences among clones. Comparative genomic analyses; including synteny and SNP calling; revealed intra-clonal differences and divergence from clade I and II references; although the variety of mutations found did not reveal possible variations at the protein level. Altogether; these findings provide novel insights into the MPXV replication cycle in vitro and the genomic characteristics of a strain isolated in Brazil during the early mpox outbreak. Keywords: Monkeypox virus; clone; phenotypic characterization; genome; SNPs; 2022 outbreak; MPOX
(This special issue belongs to the Section General Virology)
Epidemiology, Pathogenesis and Immunity of Adenovirus
edited by Adriana Kajon and
submission deadline 6 Mar 2026 | 6 articles | Viewed by 6737 | Submission Open
Keywords: human adenovirus; viral infection; pathogenesis; epidemiology; immune response; diagnosis; therapeutics; vaccine development
(This special issue belongs to the Section Human Virology and Viral Diseases)
Biotechnological Applications of Phage and Phage-Derived Proteins 2025
edited by
submission deadline 16 Mar 2026 | 3 articles | Viewed by 7484 | Submission Open
Keywords: bacteriophage; biotechnological applications; genetic engineering; antimicrobials; diagnostic
(This special issue belongs to the Section Bacterial Viruses)
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