Rift Valley Fever Virus: New Insights into a One Health Archetype

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1645

Special Issue Editors


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Guest Editor
Department of Microbiology, Immunology and Pathology, Center for Vector-Borne Infectious Diseases, Colorado State University, Fort Collins, CO 80523, USA
Interests: emerging infectious diseases; bats; mosquitoes; vector biology; arbovirology; medical entomology; disease ecology; One Health
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Guest Editor
Department of Microbiology, Immunology and Pathology, Center for Vector-Borne Infectious Diseases, Colorado State University, Fort Collins, CO 80523, USA
Interests: virus-host interactions; immunology; vector biology; virology; bats; mosquitoes

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Guest Editor
One Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Interests: epidemiology; diagnostics; vaccinology; virology; wildlife medicine; One Health

Special Issue Information

Dear Colleagues,

Rift Valley fever virus is an emerging zoonotic arbovirus that has severe health consequences for people and livestock. Historically, RVFV transmission has been restricted to the African continent; however, significant outbreaks have spread to the Arabian Peninsula, presenting a changing context of viral ecology and imminent threat of invasion to new geographic areas. Significant gaps in research pertain to viral ecology and epidemiology, host–pathogen interactions, vaccine and countermeasures development, diagnostics, virology, and vector biology and control. Global shifts in climate and weather patterns will likely potentiate the devastating consequences on humans and animals across affected regions. A transdisciplinary One Health research approach is particularly impactful in this disease system.

We are pleased to invite you to contribute original research or review articles to this Special Issue. Research areas may include (but are not limited to) field studies on viral ecology and epidemiology, veterinary aspects, molecular virology, vaccine development or clinical trials, vector factors, or detection and response approaches. Articles focused on One Health aspects of RVF are especially encouraged. We look forward to receiving your contributions by 31 January 2026

Dr. Rebekah C. Kading
Dr. Juliette Lewis
Dr. Brian H. Bird
Guest Editors

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Keywords

  • One Health
  • emerging infectious diseases
  • mosquito
  • bunyavirus
  • arbovirus
  • medical entomology
  • medical countermeasures
  • livestock

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Published Papers (1 paper)

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Research

22 pages, 1471 KB  
Article
Rift Valley Fever Virus Transmission During an Unreported Outbreak Among People and Livestock in South-Central Tanzania
by Robert D. Sumaye, Ana Pérola D. Brandão, Frank Chilanga, Goodluk Paul, Grace W. Mwangoka, Woutrina A. Smith, Abel B. Ekiri, Christopher Kilonzo, Solomon Mwakasungula, George Makingi, Amina A. Kinyogori, Walter S. Magesa, Aziza J. Samson, Catherine Mkindi, Peter Pazia, Feisal Hassan, Thabit A. Mbaga, Robinson H. Mdegela, Honorati Masanja, Deborah Cannon, Aridith Gibbons, John D. Klena, Joel M. Montgomery, Stuart T. Nichol, Lucija Jurisic, Alexandre Tremeau-Bravard, Hezron Nonga, Jamie Sebastian, Saba Zewdie, Leah Streb, Anna C. Fagre, Nicholas A. Bergren, Daniel A. Hartman, David J. Wolking, Rebekah C. Kading, Jonna A. K. Mazet and Brian H. Birdadd Show full author list remove Hide full author list
Viruses 2025, 17(10), 1329; https://doi.org/10.3390/v17101329 - 30 Sep 2025
Viewed by 1473
Abstract
Rift Valley fever (RVF) is a re-emerging vector-borne zoonotic disease that causes outbreaks in humans and animals across Africa. To better understand RVF at human–animal interfaces, a prospective longitudinal survey of people, livestock, and mosquitoes was conducted from 2016 to 2018, in two [...] Read more.
Rift Valley fever (RVF) is a re-emerging vector-borne zoonotic disease that causes outbreaks in humans and animals across Africa. To better understand RVF at human–animal interfaces, a prospective longitudinal survey of people, livestock, and mosquitoes was conducted from 2016 to 2018, in two regions of Tanzania, with distinct climatic zones (Iringa and Morogoro). Molecular and serological tools for testing (RT-qPCR and IgM/IgG ELISA) for RVF virus (RVFV) were used to assess infection and exposure in people and animals. Mosquitoes were collected quarterly from 10 sentinel locations. In total, 1385 acutely febrile humans, 4449 livestock, and 3463 mosquito pools were tested. In humans, IgM seroprevalence was 3.75% (n = 52/1385), and overall seroprevalence (IgM and/or IgG positive) was 8.30% (n = 115/1385). People from Iringa had a higher exposure risk than those from Morogoro (aOR 2.63), and livestock owners had an increased risk compared to non-owners (aOR 2.51). In livestock, IgM seroprevalence was 1.09%, while overall seroprevalence was 10.11%. A total of 68.4% of herds had at least one seropositive animal. Sentinel animal follow-up revealed that the probability of seroconversion was significantly higher in Morogoro. Low-level RVFV RNA was detected in 8 human and 22 mosquito pools. These findings indicate active transmission among vectors, livestock, and people during the study period, highlighting the need for One Health surveillance approaches for RVFV and other arboviruses. Full article
(This article belongs to the Special Issue Rift Valley Fever Virus: New Insights into a One Health Archetype)
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