Pharmacology of Antiviral Drugs, 2nd Edition

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 427

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Inc, Jacksonville, FL, USA
Interests: antiviral; influenza virus; repurposed; respiratory syncytial virus (RSV); respiratory virus; RSV; SARS-CoV-2; therapeutic
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Special Issue Information

Dear Colleagues,

Viral infections cause significant morbidity and mortality across the globe in both humans and animals. As the world emerges from the latest viral pandemic, it is clear that considerable work remains to identify and characterize new antiviral treatments. We therefore invite submissions for our upcoming Special Issue on the pharmacology of antiviral drugs. This special issue aims to explore and elucidate the intricate pharmacological aspects of antiviral medications. Researchers and experts are encouraged to contribute original research articles, reviews, and short communications that delve into various aspects of antiviral pharmacology. We welcome submissions that cover a wide range of topics, including, but not limited to, molecular interactions between drugs and viral targets, pharmacokinetics, pharmacodynamics, and the influence of host factors on drug efficacy. Additionally, we seek contributions addressing emerging topics such as drug resistance, novel drug delivery approaches, and advancements in medicinal chemistry to optimize antiviral treatment strategies in humans and animals.

Join us in advancing our understanding of antiviral pharmacology and shaping the future of antiviral therapy. Submit your contributions to this Special Issue to contribute to the global effort in combating viral infections and improving public health outcomes.

Dr. David E. Martin
Guest Editor

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Keywords

  • pharmacology
  • clinical pharmacology
  • antiviral therapy
  • antiviral prophylaxis
  • human viruses
  • animal viruses
  • pharmacokinetics
  • pharmacodynamics
  • drug resistance

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Published Papers (1 paper)

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8 pages, 776 KiB  
Case Report
Emergence of Bictegravir Resistance in a Treatment-Experienced PWH on Functional Monotherapy and Rapid Replacement by an Ancient Wild-Type Strain Following Transient Treatment Interruption
by Pietro B. Faré, Gabriela Ziltener, Judith Bergadà Pijuan, Irene A. Abela, Britta L. Hirsch, Michael Huber, Johannes Nemeth and Huldrych F. Günthard
Viruses 2025, 17(5), 699; https://doi.org/10.3390/v17050699 - 13 May 2025
Viewed by 292
Abstract
A treatment-experienced, highly adherent person living with HIV for over 25 years developed resistance mutations against all four major ART classes, including bictegravir (BIC). This led to viral failure on a quadruple regimen including BIC and doravirine (DOR). Resistance emergence was associated with [...] Read more.
A treatment-experienced, highly adherent person living with HIV for over 25 years developed resistance mutations against all four major ART classes, including bictegravir (BIC). This led to viral failure on a quadruple regimen including BIC and doravirine (DOR). Resistance emergence was associated with M184V, thymidine analog mutations (TAMs), NNRTI mutations (108I, 234I, 318F), and INSTI mutations (T97A, G140S, Q148H, G149A), likely driven by suboptimal BIC levels due to divalent cation interactions. During a two-month ART interruption, the resistant virus was rapidly replaced by an ancient wild-type strain. Despite resistance to all four ART classes, a genotype-adapted salvage regimen, including fostemsavir, achieved viral suppression within seven months. Full article
(This article belongs to the Special Issue Pharmacology of Antiviral Drugs, 2nd Edition)
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