Emerging Controversies and Advances in Neurovirology

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 21

Special Issue Editor

Special Issue Information

Dear Colleagues,

Neurovirology is rapidly evolving, driven by novel discoveries and complex new challenges. Persistent viral infections are increasingly recognized for their potential roles in chronic neurological disorders, yet causal relationships and mechanisms remain active areas of debate. Recent events, such as the neurological sequelae of SARS-CoV-2 infection, have further highlighted the intricate interplay between viral pathogens and the nervous system, sparking urgent questions about viral invasion, immune responses, and long-term outcomes.

Innovative therapeutic strategies, including the use of oncolytic viruses for brain tumors, and novel research models such as neural organoids, are pushing the boundaries of the field, while simultaneously raising important ethical, safety, and regulatory concerns. In parallel, expanding knowledge about viral latency, neuroimmune interactions, and zoonotic threats underscores the need for interdisciplinary approaches and new frameworks for understanding virus–host dynamics within the central nervous system.

This Special Issue seeks to showcase cutting-edge research, comprehensive reviews, and thought-provoking perspectives that explore both established and emerging themes in neurovirology. Contributions addressing basic mechanisms, clinical implications, novel methodologies, therapeutic innovations, or ethical considerations are all welcome. By gathering a broad spectrum of insights, we aim to foster dialogue, inspire innovation, and highlight the pivotal role of viruses in shaping nervous system health and disease.

Dr. Karolina Akinosoglou
Guest Editor

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Keywords

  • neurovirology
  • viral encephalitis
  • persistent viral infection
  • neuroinflammation
  • viral latency
  • oncolytic viruses
  • brain tumors
  • neurodegeneration
  • SARS-CoV-2
  • long COVID
  • zoonotic viruses
  • neural organoids
  • microglia activation
  • virus–host interactions
  • viral neuropathogenesis
  • central nervous system infections
  • herpesviruses
  • immune-mediated neurodegeneration
  • viral reactivation
  • ethical issues in neurovirology

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Published Papers

This special issue is now open for submission.
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