Nanoparticles to Co-Deliver Immunopotentiators and Antigens
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: closed (15 July 2016) | Viewed by 88164
Special Issue Editor
Interests: preparation methods to obtain antigen and/or immunopotentiator-loaded polymeric nanoparticles; physicochemical characterization of the nanoparticles using standardized methods and protocols; interaction studies of the nanoparticles with biological membranes and with immune cells; immunotoxicological tests with nanoparticles; immunization studies and evaluation of the cellular and humoral immune response
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Special Issue Information
Dear Colleagues,
Antigen delivery systems have primarily been used for protecting and gradually delivering antigens, achieving multimeric antigen presentation or simply mimicking the structure of virus. More recently, it has been reported that, in some cases, a direct effect on innate immune system cells is observed such as inflammasome activation, recognition by toll-like receptors, etc. Therefore, a depth and broad knowledge on the modes of action of the adjuvants will enable to better design nanoparticle-based adjuvants with predictable immune regulation. Since antigens should be close associated with adjuvants, a good strategy would be to construct nanoparticles that would be able to co-delivery immunopotentiators and recombinant antigens. Nanoparticles can have inherent immunopotentiator effect, so, the association or encapsulation of a second immunopotentiator will allow to better modulating the immune response, allowing different applications like the development of immunotherapies, or vaccines for chronic diseases.
This special issue of vaccines will cover topics close related with the emerging approaches in immunobioengineering with specific focus on considerations related with the rationale behind the design of an antigen delivery system, including, besides the recombinant antigen, the encapsulation of substances with immunopotentiator effect or for example the link of molecules that would be recognized by antigen presenting cell surface receptors.
Assist. Prof. Olga Borges
Guest Editor
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Keywords
- nanoparticles
- co-deliver
- immunopotentiators
- vaccine adjuvants
- modulation of the immune response
- Adjuvant mechanistic studies
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