Nanoparticles to Co-Deliver Immunopotentiators and Antigens

Dear Colleagues,

Antigen delivery systems have primarily been used for protecting and gradually delivering antigens, achieving multimeric antigen presentation or simply mimicking the structure of virus. More recently, it has been reported that, in some cases, a direct effect on innate immune system cells is observed such as inflammasome activation, recognition by toll-like receptors, etc. Therefore, a depth and broad knowledge on the modes of action of the adjuvants will enable to better design nanoparticle-based adjuvants with predictable immune regulation. Since antigens should be close associated with adjuvants, a good strategy would be to construct nanoparticles that would be able to co-delivery immunopotentiators and recombinant antigens. Nanoparticles can have inherent immunopotentiator effect, so, the association or encapsulation of a second immunopotentiator will allow to better modulating the immune response, allowing different applications like the development of immunotherapies, or vaccines for chronic diseases.

This special issue of vaccines will cover topics close related with the emerging approaches in immunobioengineering with specific focus on considerations related with the rationale behind the design of an antigen delivery system, including, besides the recombinant antigen, the encapsulation of substances with immunopotentiator effect or for example the link of molecules that would be recognized by antigen presenting cell surface receptors.

Assist. Prof. Olga Borges
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.