Antiviral Innate Immunity

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: closed (29 February 2016) | Viewed by 542

Special Issue Editors


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Guest Editor
Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion, INSERM UMR 1187, CNRS 9192, IRD 249. Technology platform CYROI, 2 rueMaxime Rivière, 97491 Sainte-Clotilde, La Réunion, France
Interests: molecular virology; mosquito-borne RNA virus; viral pathogenicity; viral disease; host-virus interactions; viral diagnosis; vaccine; antiviral compounds
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Unité de Recherche en Pharmaco-Immunologie (UR-EPI), Université et CHU de La Réunion, 97400 Saint-Denis, France
Interests: neuroimmunology; neuroinfection; neuroinflammation; pharmacology; innate immunity; glial immunity; microglia; complement; mesenchymal stem cells

Special Issue Information

Dear Colleagues,

An important obstacle that an invading mosquito-borne RNA virus belonging to flavivirus (e.g, dengue, West Nile, yellow fever, Japanese encephalitis, Zika), alphaviruses (e.g., Chikungunya, Ross River, Sindbis, Semliki Forest), or bunyavirus (e.g., Rift Valley fever) genus has to overcome is the host antiviral innate immunity. Understanding the mechanisms of antiviral innate immune responses provides new clues for the development of arthopod-borne virus (arbovirus) control strategies. The host immune response to arbovirus is initiated when the pattern recognition receptors recognize highly conserved motifs in viral products. In vertebrate hosts, such interactions lead to activation of transcription factors which stimulate the expression of genes encoding the type-I interferons and, which in turn, activate the expression of interferon-stimulated genes (ISGs) capable of major antiviral properties. In mosquito vector, RNAi associated to JAK/STAT pathway has been proposed as the most important mechanism of antiviral immune response. In the last years, knowledge on antiviral innate immunity to mosquito-borne RNA virus infection has greatly increased. Recent studies have also shown that arboviruses have developed sophisticated strategies to evade host innate immune responses.

This special issue of Vaccines will cover all the aforementioned topics relevant to antiviral innate immunity against mosquito-borne RNA viruses and their perturbation in both invertebrate vector and vertebrate hosts.

Prof. Dr. Philippe Desprès
Prof. Dr. Philippe Gasque
Guest Editors

Manuscript Submission Information

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Keywords

  • Arthropod-borne virus
  • RNA virus
  • mosquito-borne virus
  • flavivirus
  • alphavirus
  • bunyavirus
  • vertebrate host
  • mosquito vector
  • innate immunity
  • antiviral immune responses
  • pathogen recognition receptors
  • type-I interferon pathway
  • interferon-stimulated genes
  • insect RNAi
  • insect JAK/STAT pathway
  • cytokine
  • chemokine
  • alarmin
  • viral subversion to innate immune response

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Published Papers

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