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Special Issue "Host Defence Peptides: Modulation of Inflammation in Health and Disease"
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: closed (30 June 2018).
Manitoba Center for Proteomics and Systems Biology, Department of Internal Medicine & Immunology, University of Manitoba, Winnipeg, Canada
Interests: Immunomodulation and Inflammation: understanding molecular processes that underlie chronic inflammation; delineating the immunomodulatory functions of host defence peptides in chronic inflammatory diseases, such as arthritis and asthma; development of immunomodulatory therapies using synthetic peptides for the control of inflammatory diseases
This Special Issue of Vaccines is focused on the immunomodulatory functions of Host Defence Peptides (HDPs). Contributions to this issue are expected to encompass basic and translation research on aspects of how HDPs influence inflammation in health and disease. HDPs, also known as antimicrobial peptides, are cationic, typically amphipathic, short peptides, expressed across diverse species that include microbes, insects, amphibians, reptiles, plants and mammals. The most well-characterized HDPs in mammals are cathelicidins and defensins. HDPs are important in host defence mechanisms required for resolution of infections and modulation of inflammation. Studies in the last three decades have established that HDPs exert a wide range of functions that influence immune responses. HDPs are essential elements of innate immunity and play an integral role in the initiation, polarisation and enhancement of adaptive immune response. Immunity-related functions of HDPs influence immune homeostasis, wound healing and various aspects of the inflammatory process. It is, thus, not surprising that altered expression of HDPs have been associated with various chronic inflammatory diseases and autoimmunity. However, the role of HDPs in chronic inflammatory and autoimmune disease is not fully elucidated. Studies have demonstrated that HDPs contribute to both immune activation and regulation of inflammation, which are dependent on cellular composition, environmental stimuli and the kinetics of inflammatory response. In this Special Issue, we seek to provide insights into the complexity of mechanisms that underlie diverse immunomodulatory functions of HDPs. We also aim to include research on HDPs in chronic inflammatory disease and autoimmunity, and the application of HDPs and/or related peptides as novel immunomodulatory therapeutics.
Dr. Neeloffer Mookherjee
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Immune homeostasis
- Chronic inflammatory disease
- Innate immunity
- Antimicrobial peptides
- Immunomodulatory therapy