Special Issue "African Swine Fever Virus Prevention and Control"
Deadline for manuscript submissions: 31 August 2020.
Interests: African swine fever, vaccines, host-pathogen interactions, virus assembly and replication, protective immunity, antigen discovery
Since its introduction into Georgia in 2007, African swine fever virus has spread across both Europe and Asia and has been responsible for the deaths of hundreds of millions of animals. Virulent strains of the virus cause a haemorhagic fever to occur in domestic pigs and wild boar that is invariably fatal. Current control measures based on rapid diagnosis, quarantine, and slaughter of affected animals have not been sufficient to prevent the disease from becoming established in different epidemiological situations across the globe. The main tools missing from the African swine fever control kit are vaccines suitable for preventing disease in both domestic and wild animals. Without such vaccines, it is difficult to envisage how the current epidemic can be brought under control and the disease eradicated. Novel approaches are required, as, to date, inactivated viruses and attenutation through tissue culture passage have not yielded safe and effective vaccines. The causative agent is a complex pathogen with a complex immunopathology that is not well-characterized. Mechanisms of protective immunity and protective antigens also remain to be fully described. Due to the severity of the current African swine fever virus epidemic, alternative strategies including prophylaxsis may also need to be considered. Deployment of such novel control strategies will require the development of effective implementaiton strategies based on robust epidemiological modeling.
Dr. Christopher Netherton
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- African swine fever vaccines
- African swine fever prophalyxsis
- vaccine delivery to swine
- vaccine deployment strategies
- African swine fever virus protective immunity
- African swine fever antigen discovery and characterization
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Preventing African swine fever with or without a vaccine – complementary and alternative approaches in free-ranging pig populations and backyard farming systems
Authors: Mary Louise
Affiliation: 1 Department of Veterinary Tropical Diseases, University of Pretoria, South Africa 2 TAD Scientific CC, Menlo Park, South Africa
Abstract: The spectacular recent spread of African swine fever in Eastern Europe and Asia has been strongly associated, as it is in the endemic areas in Africa, with free-ranging wild, feral and domestic pig populations and low-biosecurity, mainly backyard pig farming. Managing the disease in wild populations and in circumstances where the disease is largely driven by poverty is particularly challenging and may remain so even in the presence of an efficacious vaccine. In the absence of vaccination, the only option currently available to prevent ASF is strict biosecurity. Among small-scale to family level pig farmers, biosecurity measures are often considered to be unaffordable both by the farmers and the government veterinary services. However, as outbreaks of ASF are also unaffordable, the adoption of at least basic biosecurity measures is imperative, and many of these depend on behaviour rather than money. A longer-term approach that could prove valuable particularly for free-ranging suid populations would be exploitation of innate resistance to the pathogenic effects of the virus, which is fully effective in wild African suids and has been observed in some domestic pig populations in long-time endemic areas. We explore the available options for preventing ASF in terms of feasibility, practicality and affordability among suid populations that are most at risk both of being decimated by ASF and of becoming a permanent source of infection for the global pig population.