The Development of Novel Cancer Immunotherapies and Target Antigens

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Cancer Vaccines and Immunotherapy".

Deadline for manuscript submissions: closed (1 January 2025) | Viewed by 2469

Special Issue Editors


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Guest Editor
Department of Pathological Anatomy Hospital '12 de Octubre', Biomedical Research Institute Hospital '12 de Octubre' IMAS12, Madrid, Spain
Interests: immune–tumor connection for the development of new therapies against brain tumor

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Guest Editor
Biomedical Innovation Unit, CIEMAT/CIBERER/IIS Fundación Jiménez Díaz, Madrid, Spain
Interests: development of novel immunotherapy approaches for treating gliomas and brain metastasis
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Special Issue Information

Dear Colleagues,

A wide variety of solid tumors still lack an effective therapy. Unfortunately, complete surgical resection often fails to completely eliminate the tumor, leading to the recurrence of cancer and resistance to current therapies. This Special Issue aims to address new immunotherapy strategies along with a description of the immunological microenvironment of tumors, which are difficult to manage clinically. Advances in the design of new strategies against cancer such as immunotherapy, neoantigen vaccines and novel immunomodulators will be evaluated. Furthermore, new immunotherapy strategies may be key to improving current immune checkpoint blockade (ICB) therapies to allow for overcoming the barriers intrinsic to the tumor microenvironment and rethinking the next steps in the evolution of cancer immunotherapy.

Dr. Ricardo Gargini
Dr. Marina I. Garin
Guest Editors

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Keywords

  • cancer immunotherapy
  • immune checkpoint blockade, ICB
  • tumor microenvironment
  • immunomodulators
  • new immune checkpoint molecules
  • cancer vaccines
  • novel vaccine platforms
  • cell-based vaccines
  • virus-based vaccines
  • peptide-based vaccines
  • nucleic-acid-based vaccines

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Published Papers (1 paper)

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Review

26 pages, 2360 KiB  
Review
Emerging Immunotherapies for Advanced Non-Small-Cell Lung Cancer
by Emily Wolf, Guilherme Sacchi de Camargo Correia, Shenduo Li, Yujie Zhao, Rami Manochakian and Yanyan Lou
Vaccines 2025, 13(2), 128; https://doi.org/10.3390/vaccines13020128 - 27 Jan 2025
Cited by 1 | Viewed by 1861
Abstract
Lung cancer remains the leading cause of cancer-related mortality worldwide. Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer, with nearly half of all patients diagnosed at an advanced stage. Immune checkpoint inhibitors (ICIs) harness the host immune system to [...] Read more.
Lung cancer remains the leading cause of cancer-related mortality worldwide. Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer, with nearly half of all patients diagnosed at an advanced stage. Immune checkpoint inhibitors (ICIs) harness the host immune system to combat malignant cells. ICIs, which target programmed death-ligand 1 (PD-L1), programmed cell death 1 (PD-1), and cytotoxic T-cell lymphocyte-4 (CTLA-4), have transformed the treatment landscape for advanced NSCLC. While a subset of patients experiences a long-term durable response, most patients will develop disease progression. New drugs targeting novel pathways are being tested in clinical trials to improve the efficacy of immunotherapy and overcome resistance patterns. This review aims to summarize the currently available ICIs for advanced NSCLC and describe emerging immunotherapies with recently published data from phase I/II clinical trials. Full article
(This article belongs to the Special Issue The Development of Novel Cancer Immunotherapies and Target Antigens)
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