Advances in Glycoconjugate Vaccines and Nanovaccines

Dear Colleagues,

Glycoconjugate vaccines, obtained by linking carbohydrates to protein carriers, have had a critical role in fighting infectious diseases. RNA-based technologies are a novel approach to developing anti-infection and anti-cancer vaccines from preclinical to clinical stages. They are particularly effective in targeting carbohydrates, one of the most important classes of surface antigens, and can also be used as adjuvants to promote immunostimulant effects.

While traditional conjugation approaches and using soluble proteins as carriers have been common, recent advancements have been made in the field. New glycosylation strategies have been established, and nanotechnology is increasingly used in vaccine development. Chemically glycosylated organic and inorganic nanoparticles are being used to enhance immunostimulation and delivery. Finally, the complexity of glycoconjugate structures requires suitable analytical methods to support their design and development.

We are pleased to invite you to contribute to this Special Issue, which will focus on recent advancements in the design, development, and characterization of glycosylated proteins and nanoparticles as potential vaccines. The Special Issue is open to original research articles and reviews on antigenic/immunogenic oligosaccharides or new glyco-derivatives, as well as pre-clinical and clinical studies on anti-infection or anticancer glyco-(nano)vaccines. Investigations on analytical approaches to support the design and production of glycoconjugates will also be considered.

We look forward to receiving your contributions.

Prof. Dr. Marco Terreni
Dr. Sara Tengattini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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