PFAS Toxicology and Metabolism—2nd Edition

Dear Colleagues,

Per- and polyfluoroalkyl substances (PFASs) have multiple beneficial uses, widespread occurrences, and numerous known and potential adverse health effects. The high number, variety of chemical properties, and extensive distribution of PFASs complicate research with the intent of more deeply understanding environmental and human health impacts. The published literature provides strong evidence of human health effects caused by the first known PFASs, perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS). However, gaps in toxicity data for legacy and emerging PFASs in this structurally diverse class persist.  

Volume 1 of the Special Issue PFAS Toxicology and Metabolism presented original research and reviews describing new approach methods (NAMs), toxicokinetics, fate and bioaccumulation, metabolism, transport, toxicity, comparative toxicity, and the adverse effects of multiple PFAS and PFAS mixtures. This Special Issue of Toxics aims to further expand our knowledge of the health and environmental effects of per- and polyfluoroalkyl substances. We welcome original research, new methodologies and protocols, and reviews of the toxicity and metabolisms of emerging PFASs with little available toxicity data, as well as methods for rapid toxicity assessment and NAMS, the use of non-targeted analytical (NTA) approaches for gathering data on biotransformations, and systems-level biological data (lipidomics, metabolomics), cross-species comparisons, and assessments of PFAS mixtuures. Research may include in vivo, in vitro, and in silico studies. We also welcome research in areas including, but not limited to, in vivo dose–response studies that evaluate health effects related to sub-chronic and chronic exposure at environmentally relevant levels; PFAS biomonitoring; bioaccumulation; dosimetry; toxicokinetics and in vitro–in vivo extrapolation (IVIVE); integrated omics; neurotoxicity; developmental and reproductive toxicology; and endocrine disruption.

Dr. Denise MacMillan
Prof. Dr. William S. Baldwin
Dr. Subham Dasgupta
Guest Editors

Manuscript Submission Information

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• PFAS
• toxicity
• metabolism
• toxicokinetics
• adverse outcomes
• omics
• biotransformation
• biomonitoring
• new approach methodologies (NAMs)
• non-targeted analysis (NTA)

• PFAS Toxicology and Metabolism in Toxics (18 articles)