Special Issue "Oligonucleotides and Nucleic-Acid-Based Strategies to Address Therapeutic Challenges: From the Bench to the Bedside"
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 31705
Interests: pharmaceutical development; formulation and delivery; nucleic acid derivatives
Interests: modified oligonucleotides; nucleic acid bioconjugates for multiple applications; ranging from molecular building blocks for self-assemblies to biomedical and therapeutic applications
Special Issues, Collections and Topics in MDPI journals
The recent pandemic events have demonstrated the importance of alternative strategies to tackle new therapeutic challenges and unmet needs. Oligonucleotides and nucleic-acid-based drugs have appeared as a promising but underused strategy. Whereas the concept of oligonucleotides for therapeutic purposes goes back to the late nineties, several commercialized therapies have made the proof of concept of their therapeutic potential. The growing interest for this field in certain research areas allows for an increase in the known information and the possible applications. The rational design and the choice of the type of nucleic acid allows one to optimize the mechanism of action. Chemical modifications and conjugations of nucleic acids confer the prolonged half-life, but also enhanced efficacy, due to better controlled pharmacokinetics and increased specificity while reducing the target effects. The recent success of lipid nanoparticles for nucleic acid delivery has underlined the importance of their formulation. The aim of this Special Issue is to highlight and structure the knowledge available in terms of design strategy, chemistry used, delivery systems and therapeutic applications.
Dr. Tina Kauss
Prof. Dr. Philippe Barthélémy
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- nucleic acid
- chemically modified