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Pharmaceutics
Special Issues
Transforming Textbook Concepts into Novel Drug Delivery Systems
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Transforming Textbook Concepts into Novel Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (10 December 2022) | Viewed by 4636

Special Issue Editor

Dr. Aeri Kim

E-Mail Website
Guest Editor
College of Pharmacy, CHA University, Seongnam-si 463-400, Gyeonggi-do, Korea
Interests: liposomes; polymeric micelles; coacervates; pulmonary targeting; wound healing; solid dispersion; cocrystal; SMEDDS; controlled release

Special Issue Information

Dear Colleagues,

Recent scientific advancements in understanding the pathophysiology of diseases, identifying novel targets and molecules, call for further innovation in formulations and delivery systems. Although many pharmaceutical formulations and drug delivery technologies are described in textbooks, pharmaceutical scientists are still making efforts to transform the already known scientific concepts into novel delivery systems with enhanced efficacy and safety profiles. Their efforts are worth the attention of others in this field because bringing a novel delivery system to clinical application often requires overcoming several barriers one might face during research. Sharing such efforts will benefit others in the area collectively and eventually accelerate the development of novel products that patients need. This Special Issue highlights some of the most promising approaches that identify disadvantages of conventional formulations or delivery systems and provide solutions to those challenges. We invite articles on all aspects of such research in this field, which may help to accelerate the development of novel formulations or delivery systems and their clinical applications.

Dr. Aeri Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

15 pages, 4127 KiB  
Article
Cupriavidus necator-Produced Polyhydroxybutyrate/Eudragit FS Hybrid Nanoparticles Mitigates Ulcerative Colitis via Colon-Targeted Delivery of Cyclosporine A
by Juho Lee, Aruzhan Saparbayeva, Shwe Phyu Hlaing, Dongmin Kwak, Hyunwoo Kim, Jihyun Kim, Eun Hee Lee and Jin-Wook Yoo
Pharmaceutics 2022, 14(12), 2811; https://doi.org/10.3390/pharmaceutics14122811 - 15 Dec 2022
Cited by 6 | Viewed by 1486
Abstract
Polyhydroxybutyrate (PHB) has emerged as a novel material for replacing various plastics used in the medical field. However, its application as a drug-delivery carrier for colitis-targeted delivery has not been explored. In this study, we used biosynthesized PHB combined with Eudragit FS (EFS) [...] Read more.
Polyhydroxybutyrate (PHB) has emerged as a novel material for replacing various plastics used in the medical field. However, its application as a drug-delivery carrier for colitis-targeted delivery has not been explored. In this study, we used biosynthesized PHB combined with Eudragit FS (EFS) and cyclosporine A (CSA) to develop pH-responsive controlled CSA-releasing nanoparticles (CSA-PENPs) for colitis-targeted drug delivery and demonstrated its enhanced therapeutic efficacy in a dextran sulfate sodium (DSS)-induced murine colitis model. PHB was successfully biosynthesized in the bacterium Cupriavidus necator, as demonstrated by 1H-NMR and FT-IR analyses. CSA-PENPs were fabricated via the oil-in-water emulsion solvent evaporation method. Owing to the potent pH-responsive and sustained drug release properties provided by PHB and EFS, CSA-PENPs could deliver a sufficient amount of CSA to inflamed tissues in the distal colon; in contrast, CSA-loaded EFS nanoparticles displayed premature burst release before reaching the target site. Due to enhanced CSA delivery to colitis tissues, CSA-PENPs exhibited potent anti-inflammatory effects in the DSS-induced murine colitis model. Overall, CSA-PENPs could be a promising drug-delivery system for treating ulcerative colitis. Full article
(This article belongs to the Special Issue Transforming Textbook Concepts into Novel Drug Delivery Systems)
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12 pages, 7997 KiB  
Article
Preparation of PLGA Nanoparticles by Milling Spongelike PLGA Microspheres
by Jimin Lee and Hongkee Sah
Pharmaceutics 2022, 14(8), 1540; https://doi.org/10.3390/pharmaceutics14081540 - 24 Jul 2022
Cited by 6 | Viewed by 2807
Abstract
Currently, emulsification-templated nanoencapsulation techniques (e.g., nanoprecipitation) have been most frequently used to prepare poly-d,l-lactide-co-glycolide (PLGA) nanoparticles. This study aimed to explore a new top-down process to produce PLGA nanoparticles. The fundamental strategy was to prepare spongelike PLGA [...] Read more.
Currently, emulsification-templated nanoencapsulation techniques (e.g., nanoprecipitation) have been most frequently used to prepare poly-d,l-lactide-co-glycolide (PLGA) nanoparticles. This study aimed to explore a new top-down process to produce PLGA nanoparticles. The fundamental strategy was to prepare spongelike PLGA microspheres with a highly porous texture and then crush them into submicron-sized particles via wet milling. Therefore, an ethyl formate-based ammonolysis method was developed to encapsulate progesterone into porous PLGA microspheres. Compared to a conventional solvent evaporation process, the ammonolysis technique helped reduce the tendency of drug crystallization and improved drug encapsulation efficiency accordingly (solvent evaporation, 27.6 ± 4.6%; ammonolysis, 65.1 ± 1.7%). Wet milling was performed on the highly porous microspheres with a D50 of 64.8 μm under various milling conditions. The size of the grinding medium was the most crucial factor for our wet milling. Milling using smaller zirconium oxide beads (0.3~1 mm) was simply ineffective. However, when larger beads with diameters of 3 and 5 mm were used, our porous microspheres were ground into submicron-sized particles. The quality of the resultant PLGA nanoparticles was demonstrated by size distribution measurement and field emission scanning electron microscopy. The present top-down process that contrasts with conventional bottom-up approaches might find application in manufacturing drug-loaded PLGA nanoparticles. Full article
(This article belongs to the Special Issue Transforming Textbook Concepts into Novel Drug Delivery Systems)
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