Drug Delivery across the Blood–Brain Barrier: Latest Advances and Prospects
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 6467
Special Issue Editor
Special Issue Information
Dear Colleagues,
The structural and physiological properties of the blood–brain barrier (BBB) present a challenging obstacle to drug delivery to the central nervous system (CNS), limiting the treatment of many CNS diseases. The therapeutic molecule must reach the target cell in a sufficient concentration and in a suitable time frame in order for the treatment to be effective. Different approaches to improve delivery and circumvent the BBB may be local, regional, or global, and can be simulated by using in silico, in vitro, and in vivo models to understand and improve the specific mechanisms of drug permeation across the BBB. Overall, these experimental and theoretical techniques and strategies at different levels of complexity could provide new insights and future directions for diagnosis, treatment improvement, and a deeper understanding of BBB-related neuropathological events.
Prof. Dr. Sergey Shityakov
Guest Editor
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Keywords
- blood–brain barrier
- molecular modeling
- biomedicine
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