Metal Nanoparticles for Pharmaceutical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (30 June 2025) | Viewed by 823

Special Issue Editors


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Guest Editor
Department of Chemistry, Pittsburg State University, 1701 South Broadway Street, Pittsburg, KS 66762, USA
Interests: drug delivery; electrospinning; layer-by-layer; scaffolds; wound dressings; antimicrobial coatings; hydrogels; polysaccharides; cytocompatibility; hemocompatibility; polymer-based composites; metallic nanoparticles; mammalian cells
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Guest Editor
Independent Researcher, Toronto, ON, Canada
Interests: nanotechnology; theranostics; cancer; therapy; imaging
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Special Issue Information

Dear Colleagues,

Nanoparticles present a platform for a diverse array of applications. Metal-based nanoparticles have gained attention due to their significant inert nature and ability to control their size, shape, and charge using a variety of synthesis methods. Their intrinsic electronic, magnetic, and optical (e.g., surface plasmon resonance) characteristics have made it possible to use metallic nanoparticles for numerous biomedical applications such as imaging, drug delivery, photothermal, and photodynamic therapy. Modalities that can be used for contrast-enhanced medical imaging include photoacoustic, nuclear, and magnetic resonance imaging. The surface of metal nanoparticles can also be modified to actively target cells, such as cancer cells, for improving the accumulation of nanoparticles. Moieties such as antibodies, peptides, small molecules, and aptamers can be introduced on the surface of nanoparticles through conjugation, using a variety of functionalization methods. This enables nanoparticles to attach to specific membrane proteins that are highly expressed, providing superior efficacy and minimizing off-target effects.

This Special Issue will highlight metal nanoparticles for biomedical applications and welcomes articles in this field. Review articles by experts on the development and advancements in this important field are also welcome.

Dr. Alessandro Francisco Martins
Dr. Donald Fernandes
Guest Editors

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Keywords

  • biomedical
  • diagnosis
  • therapy
  • imaging
  • metal nanoparticles

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Published Papers (1 paper)

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Review

37 pages, 3778 KB  
Review
Peptide-Based Inorganic Nanoparticles as Efficient Intracellular Delivery Systems
by Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer, Anthony Nguyen, Vian Khoury and Keykavous Parang
Pharmaceutics 2025, 17(9), 1123; https://doi.org/10.3390/pharmaceutics17091123 - 28 Aug 2025
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Abstract
Background/Objectives: Peptide-based inorganic nanoparticles (PINPs) have emerged as promising candidates for intracellular delivery due to their unique structural and functional attributes. These hybrid nanostructures combine the high surface area and tunable optical/magnetic properties of metal cores (e.g., Au, Ag, Fe3O [...] Read more.
Background/Objectives: Peptide-based inorganic nanoparticles (PINPs) have emerged as promising candidates for intracellular delivery due to their unique structural and functional attributes. These hybrid nanostructures combine the high surface area and tunable optical/magnetic properties of metal cores (e.g., Au, Ag, Fe3O4) with the biocompatibility, targeting specificity, and responsive behavior of peptides. In particular, peptides with amphipathic or cell-penetrating features could facilitate efficient transport of molecular cargos across cellular membranes while enabling stimulus-responsive drug release in target tissues. Methods: We review key synthesis methods (especially green, peptide-mediated one-pot approaches), functionalization strategies (e.g., thiol-gold bonds, click chemistries), and characterization techniques (TEM, DLS, FTIR, etc.) that underpin PINP design. In addition, we highlight diverse peptide classes (linear, cyclic, amphipathic, self-assembling) and their roles (targeting ligands, capping/stabilizing agents, reducing agents) in constructing multifunctional nanocarriers. Results: The prospects of PINPs are considerable: they enable targeted drug delivery with imaging/theranostic capability, improve drug stability and cellular uptake, and harness peptide programmability for precision nanomedicine. However, challenges such as in vivo stability, immunogenicity, and standardization of evaluation must be addressed. Conclusions: Overall, PINPs represent multifunctional platforms that could significantly advance drug delivery and diagnostic applications in the future. Full article
(This article belongs to the Special Issue Metal Nanoparticles for Pharmaceutical Applications)
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