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Pharmaceutics
Special Issues
Preparation and Development of Amorphous Solid Dispersions
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Preparation and Development of Amorphous Solid Dispersions

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1285

Special Issue Editors

Prof. Dr. Judyta Cielecka-Piontek

E-Mail Website
Guest Editor
Department of Pharmacognosy and Biomaterials, Poznań University of Medical Sciences, 60-806 Poznań, Poland
Interests: drug delivery systems; biomaterials; functional foods; pharmaceutical products; wound care
Special Issues, Collections and Topics in MDPI journals
Dr. Szymon Sip

E-Mail Website
Guest Editor
Department of Pharmacognosy and Biomaterials, Faculty of Pharmacy, Poznań University of Medical Sciences, Rokietnicka 3, 60-806 Poznań, Poland
Interests: amorphous; polyphenols; senolytics; supercritical CO2; microbiome

Special Issue Information

Dear Colleagues,

Amorphous solid dispersions (ASDs) have emerged as a key strategy with which to enhance the bioavailability of poorly water-soluble drugs. By converting crystalline drugs into amorphous forms and stabilising them in a polymer matrix, ASDs can significantly improve their solubility, dissolution rate, and absorption. However, challenges related to their stability, manufacturing, and scalability remain active research areas.

This Special Issue seeks to explore recent advances in the preparation, characterisation, and development of ASDs. We invite original research articles and reviews on novel preparation techniques, stabilisation mechanisms, in vitro and in vivo performance, and industrial applications. Contributions addressing challenges in process optimisation, scale-up, and regulatory considerations are encouraged.

We look forward to your submissions, which will contribute to advancing the field of amorphous solid dispersions and enhancing the therapeutic effectiveness of drugs.

Prof. Dr. Judyta Cielecka-Piontek
Dr. Szymon Sip
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • amorphous solid dispersions
  • drug solubility enhancement
  • bioavailability improvement
  • polymer matrix stabilization
  • pharmaceutical formulation

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Published Papers (1 paper)

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Research

27 pages, 12316 KiB  
Article
Application of the Box–Behnken Design in the Development of Amorphous PVP K30–Phosphatidylcholine Dispersions for the Co-Delivery of Curcumin and Hesperetin Prepared by Hot-Melt Extrusion
by Kamil Wdowiak, Lidia Tajber, Andrzej Miklaszewski and Judyta Cielecka-Piontek
Pharmaceutics 2025, 17(1), 26; https://doi.org/10.3390/pharmaceutics17010026 - 27 Dec 2024
Viewed by 983
Abstract
Background: Curcumin and hesperetin are plant polyphenols known for their poor solubility. To address this limitation, we prepared amorphous PVP K30–phosphatidylcholine dispersions via hot-melt extrusion. Methods: This study aimed to evaluate the effects of the amounts of active ingredients and phosphatidylcholine, as well [...] Read more.
Background: Curcumin and hesperetin are plant polyphenols known for their poor solubility. To address this limitation, we prepared amorphous PVP K30–phosphatidylcholine dispersions via hot-melt extrusion. Methods: This study aimed to evaluate the effects of the amounts of active ingredients and phosphatidylcholine, as well as the process temperature, on the performance of the dispersions. A Box–Behnken design was employed to assess these factors. Solid-state characterization and biopharmaceutical studies were then conducted. X-ray powder diffraction (XRPD) was used to confirm the amorphous nature of the dispersions, while differential scanning calorimetry (DSC) provided insight into the miscibility of the systems. Fourier-transform infrared spectroscopy (FTIR) was employed to assess the intermolecular interactions. The apparent solubility and dissolution profiles of the systems were studied in phosphate buffer at pH 6.8. In vitro permeability across the gastrointestinal tract and blood–brain barrier was evaluated using the parallel artificial membrane permeability assay. Results: The quantities of polyphenols and phospholipids were identified as significant factors influencing the biopharmaceutical performance of the systems. Solid-state analysis confirmed the formation of amorphous dispersions and the development of interactions among components. Notably, a significant improvement in solubility was observed, with formulations exhibiting distinct release patterns for the active compounds. Furthermore, the in vitro permeability through the gastrointestinal tract and blood–brain barrier was enhanced. Conclusions: The findings suggest that amorphous PVP K30–phosphatidylcholine dispersions have the potential to improve the biopharmaceutical properties of curcumin and hesperetin. Full article
(This article belongs to the Special Issue Preparation and Development of Amorphous Solid Dispersions)
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