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Pharmaceutics
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Natural and Synthetic Compounds in Pharmaceutical Formulations and Drug Delivery...
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Natural and Synthetic Compounds in Pharmaceutical Formulations and Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 4069

Special Issue Editors

Prof. Dr. Ademar Alves Da Silva Filho

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Guest Editor
Faculdade de Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Juiz de Fora, R. José Lourenço Kelmer s/n, Campus Universitário, Juiz de Fora 36036-900, MG, Brazil
Interests: chemistry and biological activities of natural products; antischistosomal compounds; propolis and medicinal plants
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Guilherme Diniz Tavares

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Guest Editor
Faculdade de Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Juiz de Fora, R. José Lourenço Kelmer s/n, Campus Universitário, Juiz de Fora 36036-900, MG, Brazil
Interests: development and characterization of polymeric; lipidic nanocarriers for drug delivery; pulmonary drug delivery
Prof. Dr. Frederico Pittella

E-Mail Website
Guest Editor
Faculdade de Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Juiz de Fora, R. José Lourenço Kelmer s/n, Campus Universitário, Juiz de Fora 36036-900, MG, Brazil
Interests: siRNA; RNAi; nanoparticles; nanocarriers; qPCR; molecular biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural and synthetic compounds may be applied in various pharmaceutical formulations, including in nanosized drug delivery systems. Numerous natural products derived from plants, marine or microbial sources have fascinating biological activities, offering novel prospects for the drug discovery process. In addition, synthetic bioactive compounds or semisynthetic natural derivatives may be produced as promising candidates for treating diseases. On the other hand, various chemical properties, including stability, or biological properties, such as pronounced adverse effects, may limit their clinical application. To overcome these challenges in the development of pharmaceutical products, drug delivery systems incorporating natural or synthetic compounds may be developed. In this sense, conventional formulations (e.g., tablets, capsules, creams, gels, etc.) or nanosized drug delivery systems (such as, liposomes, micelles, dendrimers, polymeric nanoparticles, etc.) could be designed in order to enhance the stability and biopharmaceutical properties of formulations, and ensure the efficacy and safety of the active ingredient.

This Special Issue aims to address recent research on the biological/therapeutic activities of formulations containing natural molecules, semi-synthetic derivatives, and synthetic compounds, including the isolation, purification, synthesis and biological evaluation of the molecules. Manuscripts that reflect novel approaches to the design and development of drug delivery systems containing natural, semi-synthetic, and synthesized molecules for the treatment of diseases are especially welcome.

We are pleased to invite you to submit original and review articles attending to all aspects of delivery systems with natural products, semi-synthetic derivatives, and synthesized compounds.

In this Special Issue, original research articles and reviews are welcome. Research areas may include, but are not limited to, the following:

  • Drug design, development and delivery systems with natural products, semi-synthetic derivatives, and synthetic compounds;
  • In vitro and in vivo studies of all drug delivery systems with natural products, semi-synthetic derivatives, and synthetic compounds;
  • Drug delivery properties, manufacturing processes, and quality control studies with natural products, semi-synthetic derivatives, and synthetic compounds;
  • Microparticles, nanoparticles, and macromolecular conjugates as drug delivery systems for natural products, semi-synthetic derivatives, and synthetic compounds;
  • Conventional drug delivery systems for natural products, semi-synthetic derivatives, and synthetic compounds;
  • Physicochemical and chemical methods for drug delivery systems with natural products, semi-synthetic derivatives, and synthetic compounds;
  • Innovative aspects of drug delivery systems with natural products, semi-synthetic derivatives, and synthetic compounds;
  • Bioavailability and drug delivery systems employing natural products, semi-synthetic derivatives, and synthetic compounds.

We look forward to receiving your contributions.

Prof. Dr. Ademar Alves Da Silva Filho
Prof. Dr. Guilherme Diniz Tavares
Prof. Dr. Frederico Pittella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • synthetic compounds
  • drug delivery systems
  • nanotechnology
  • pharmaceutical formulations

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Published Papers (2 papers)

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Research

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16 pages, 2621 KiB  
Article
New Chalcone-Derived Molecule for the Topical Regulation of Hyperpigmentation and Skin Aging
by Alfredo Martínez-Gutiérrez, Alexandra Bertran, Teresa Noya, Eloy Pena-Rodríguez, Susana Gómez-Escalante, Sergio Pascual, Luis Shotze Luis and Mari Carmen González
Pharmaceutics 2024, 16(11), 1405; https://doi.org/10.3390/pharmaceutics16111405 - 31 Oct 2024
Viewed by 1497
Abstract
Background/Objectives: Skin hyperpigmentation is a biological process that results in an excessive production of melanin and is highly regulated by several mechanisms, tyrosinase being one of the key enzymes involved. Current reported inhibitors lack clinical efficacy, show toxic side effects, have poor [...] Read more.
Background/Objectives: Skin hyperpigmentation is a biological process that results in an excessive production of melanin and is highly regulated by several mechanisms, tyrosinase being one of the key enzymes involved. Current reported inhibitors lack clinical efficacy, show toxic side effects, have poor bioavailability, or low formulation compatibility. The aim of this study was to design a new effective tyrosinase inhibitor for topical hyperpigmentation and anti-aging treatments. Methods: Homology modeling was used to build the tridimensional structure of human tyrosinase, and virtual docking was used to predict molecule–enzyme binding modes. The tyrosinase activity of the designed and synthesized compounds was assessed and water solubility was determined by HPLC. Cell assays were performed to determine melanin content, cytotoxicity, wound healing, anti-glycation, antioxidation, and autophagy efficacy. Gene expression and miRNA levels were quantified by qPCR and chromatin accessibility by ATAC-Seq. Human reconstructed epidermis was used to test the depigmenting efficacy as well as the skin irritation potential. Results: The 3D structure of human tyrosinase was designed and validated. The new molecule could effectively inhibit human tyrosinase and melanin synthesis in 2D monocultures and a 3D epidermis model. Two melanogenesis-related miRNAs were increased in treated cells. Anti-glycation, antioxidant, mitochondria protection, autophagy activation, and wound healing properties were also observed, with special emphasis on epigenetics. Conclusions: The designed molecule is a potential candidate to be used as a depigmenting and anti-aging agent, with suitable properties to be introduced in final product formulations for dermatology or cosmetics treatments. Full article
(This article belongs to the Special Issue Natural and Synthetic Compounds in Pharmaceutical Formulations and Drug Delivery Systems)
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Review

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31 pages, 3407 KiB  
Review
Glucose Metabolism-Modifying Natural Materials for Potential Feed Additive Development
by Wei-Chih Lin, Boon-Chin Hoe, Xianming Li, Daizheng Lian and Xiaowei Zeng
Pharmaceutics 2024, 16(9), 1208; https://doi.org/10.3390/pharmaceutics16091208 - 13 Sep 2024
Cited by 2 | Viewed by 1890
Abstract
Glucose, a primary energy source derived from animals’ feed ration, is crucial for their growth, production performance, and health. However, challenges such as metabolic stress, oxidative stress, inflammation, and gut microbiota disruption during animal production practices can potentially impair animal glucose metabolism pathways. [...] Read more.
Glucose, a primary energy source derived from animals’ feed ration, is crucial for their growth, production performance, and health. However, challenges such as metabolic stress, oxidative stress, inflammation, and gut microbiota disruption during animal production practices can potentially impair animal glucose metabolism pathways. Phytochemicals, probiotics, prebiotics, and trace minerals are known to change the molecular pathway of insulin-dependent glucose metabolism and improve glucose uptake in rodent and cell models. These compounds, commonly used as animal feed additives, have been well studied for their ability to promote various aspects of growth and health. However, their specific effects on glucose uptake modulation have not been thoroughly explored. This article focuses on glucose metabolism is on discovering alternative non-pharmacological treatments for diabetes in humans, which could have significant implications for developing feed additives that enhance animal performance by promoting insulin-dependent glucose metabolism. This article also aims to provide information about natural materials that impact glucose uptake and to explore their potential use as non-antibiotic feed additives to promote animal health and production. Further exploration of this topic and the materials involved could provide a basis for new product development and innovation in animal nutrition. Full article
(This article belongs to the Special Issue Natural and Synthetic Compounds in Pharmaceutical Formulations and Drug Delivery Systems)
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