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Pharmaceutics
Special Issues
Application of Supercritical Fluid to Particulate Systems
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Application of Supercritical Fluid to Particulate Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 7258

Special Issue Editor

Prof. Dr. Marco Chaud

E-Mail Website
Guest Editor
Laboratory of Biomaterials and Nanotechnology, University of Sorocaba, Sao Paulo, Brazil
Interests: biomaterial; nanotechnology; drug bioavailability; target delivery; drug encapsulation; agrochemical encapsulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to announce that I will be the Guest Editor of a Special Issue on “Application of Supercritical Fluid to Particulate Systems” in the Pharmaceutics journal. I invite all scientists around the world to present their research results to a wide audience. Original research articles and comprehensive review articles are very welcome from RD&I in the supercritical fluid area carried out at institutes, universities, and industries.

Supercritical fluid (SCF) technology is mainly used to optimize the production of drug nanonization and particulate systems for drug delivery, bioactive extraction, and chromatography. One of the critical aspects of SCF technology is the assortment of topics associated with it, all of which should be of interest to researchers and industrialists. The flexibility of SCF technology in providing safe alternative processing environments compared to those of long-established operations has enabled innovative solutions to challenging pharmaceutical situations.

Substance manipulation under supercritical conditions, that is, above a substance’s critical temperature and pressure, is attractive for a range of procedures for demanding materials, pharmaceutical operations, and blend formation. This ranges from “green” technology concepts to impressive particle design opportunities for targeted particle size and size distributions, as well as directed chemical, crystallographic, and physical characteristics. A more recent approach toward surface modification, dispersibility, single nanocrystal formation, and morphology control of nanoparticles demonstrates the versatility of SCF technologies for functionalized coverage for specific targeting purposes such as theranostics, biosensors, antigen-presenting cells, tumoral cells, and antigen-presenting cells. 

Prof. Dr. Marco Chaud
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • supercritical fluid technology
  • nanonization
  • nanoparticle
  • microparticle
  • drug delivery system
  • tissue-specific target
  • stimuli-triggered drug delivery
  • medical devices

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Published Papers (2 papers)

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20 pages, 5642 KiB  
Article
Aspirin-Loaded Polymeric Films for Drug Delivery Systems: Comparison between Soaking and Supercritical CO2 Impregnation
by Isabela Trindade Coutinho, Lígia Passos Maia-Obi and Mathilde Champeau
Pharmaceutics 2021, 13(6), 824; https://doi.org/10.3390/pharmaceutics13060824 - 2 Jun 2021
Cited by 18 | Viewed by 4274
Abstract
Polymeric implants loaded with drugs can overcome the disadvantages of oral or injection drug administration and deliver the drug locally. Several methods can load drugs into polymers. Herein, soaking and supercritical CO2 (scCO2) impregnation methods were employed to load aspirin [...] Read more.
Polymeric implants loaded with drugs can overcome the disadvantages of oral or injection drug administration and deliver the drug locally. Several methods can load drugs into polymers. Herein, soaking and supercritical CO2 (scCO2) impregnation methods were employed to load aspirin into poly(l-lactic acid) (PLLA) and linear low-density polyethylene (LLDPE). Higher drug loadings (DL) were achieved with scCO2 impregnation compared to soaking and in a shorter time (3.4 ± 0.8 vs. 1.3 ± 0.4% for PLLA; and 0.4 ± 0.5 vs. 0.6 ± 0.5% for LLDPE), due to the higher swelling capacity of CO2. The higher affinity of aspirin explained the higher DL in PLLA than in LLDPE. Residual solvent was detected in LLDPE prepared by soaking, but within the FDA concentration limits. The solvents used in both methods acted as plasticizers and increased PLLA crystallinity. PLLA impregnated with aspirin exhibited faster hydrolysis in vitro due to the catalytic effect of aspirin. Finally, PLLA impregnated by soaking showed a burst release because of aspirin crystals on the PLLA surface, and released 100% of aspirin within 60 days, whereas the PLLA prepared with scCO2 released 60% after 74 days by diffusion and PLLA erosion. Hence, the scCO2 impregnation method is adequate for higher aspirin loadings and prolonged drug release. Full article
(This article belongs to the Special Issue Application of Supercritical Fluid to Particulate Systems)
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9 pages, 13492 KiB  
Article
Supercritical CO2 Extraction of Organic Solvents from Flunisolide and Fluticasone Propionate
by Lucia Baldino, Mariarosa Scognamiglio and Ernesto Reverchon
Pharmaceutics 2021, 13(5), 612; https://doi.org/10.3390/pharmaceutics13050612 - 23 Apr 2021
Cited by 6 | Viewed by 2328
Abstract
In this work, Class 2 and Class 3 solvents contained in two corticosteroids, flunisolide (Fluni) and fluticasone propionate (Fluti), were reduced to a few ppm by supercritical CO2 extraction. The process was carried out at pressures from 80 to 200 bar, temperatures [...] Read more.
In this work, Class 2 and Class 3 solvents contained in two corticosteroids, flunisolide (Fluni) and fluticasone propionate (Fluti), were reduced to a few ppm by supercritical CO2 extraction. The process was carried out at pressures from 80 to 200 bar, temperatures of 40 °C and 80 °C, and at a fixed CO2 flow rate of 0.7 kg/h. The results demonstrated that CO2 density is the key parameter influencing the extraction kinetics and the solvent final residue. In particular, in the range investigated, optimal pressure and temperature conditions for the extraction of residual organic solvents were found working at 200 bar and 40 °C, which corresponds to a CO2 density of 0.840 g/cm3. Operating in this way, total organic solvent residues were reduced from 13,671 ppm and 326 ppm to 12 ppm and 10 ppm for Fluni and Fluti, respectively. Full article
(This article belongs to the Special Issue Application of Supercritical Fluid to Particulate Systems)
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