Microarray Patches for Transdermal Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 2185

Special Issue Editors


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Guest Editor
Leicester Institute for Pharmaceutical Innovation, Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK
Interests: drug delivery; controlled release; nanomedicine; vaccine delivery; transdermal delivery; microneedles; diagnostics
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Guest Editor
School of Pharmacy, Queen’s University Belfast, Belfast, UK
Interests: drug delivery; microarray patches; nanosuspensions; biotherapeutics; clinical translation

Special Issue Information

Dear Colleagues,

Nearly 25 years on from the publication of the first paper on microarray patch-mediated drug delivery, the field is now tantalisingly close to achieving a commercial product. The World Economic Forum for instance has listed microarray patches as one of the Top Ten Emerging Technologies in 2020. This is owing to the number of advantages microarray patches can offer over the current routes of drug administration, such as the ability to avoid first-pass metabolism and gastrointestinal degradation, pain-free administration and avoidance of needle-stick injuries common with hypodermic syringes. To date, the transdermal delivery of both small and large molecules for therapeutic applications has been investigated using hollow, coated, dissolving, hydrogel-forming and porous microarray patch designs. Therefore, the aim of this Special Issue is to provide insights into the current and future developments of microarray patch-mediated transdermal drug delivery and how this can truly achieve patient and commercial benefits. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) scalable manufacturing methods to aid commercialisation, delivery of biologics, development approaches to achieve long-acting transdermal drug delivery, end-user considerations and product designs.

We look forward to receiving your contributions.

Dr. Ana Sara Cordeiro
Dr. Aaron Hutton
Guest Editors

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Keywords

  • microarray patches
  • manufacturing methods
  • biotherapeutic agents
  • long-acting transdermal drug delivery
  • end-user microarray patch designs

Published Papers (1 paper)

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Review

17 pages, 1788 KiB  
Review
Microneedle-Mediated Transdermal Delivery of Genetic Materials, Stem Cells, and Secretome: An Update and Progression
by Avelia Devina Calista Nainggolan, Qonita Kurnia Anjani, Pietradewi Hartrianti, Ryan F. Donnelly, Arief Kurniawan and Delly Ramadon
Pharmaceutics 2023, 15(12), 2767; https://doi.org/10.3390/pharmaceutics15122767 - 13 Dec 2023
Viewed by 1505
Abstract
Medical practitioners commonly use oral and parenteral dosage forms to administer drugs to patients. However, these forms have certain drawbacks, particularly concerning patients’ comfort and compliance. Transdermal drug delivery presents a promising solution to address these issues. Nevertheless, the stratum corneum, as [...] Read more.
Medical practitioners commonly use oral and parenteral dosage forms to administer drugs to patients. However, these forms have certain drawbacks, particularly concerning patients’ comfort and compliance. Transdermal drug delivery presents a promising solution to address these issues. Nevertheless, the stratum corneum, as the outermost skin layer, can impede drug permeation, especially for macromolecules, genetic materials, stem cells, and secretome. Microneedles, a dosage form for transdermal delivery, offer an alternative approach, particularly for biopharmaceutical products. In this review, the authors will examine the latest research on microneedle formulations designed to deliver genetic materials, stem cells, and their derivatives. Numerous studies have explored different types of microneedles and evaluated their ability to deliver these products using preclinical models. Some of these investigations have compared microneedles with conventional dosage forms, demonstrating their significant potential for advancing the development of biotherapeutics in the future. Full article
(This article belongs to the Special Issue Microarray Patches for Transdermal Drug Delivery)
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