Personalizing Drug Therapy: The Role of Pharmacokinetics and Therapeutic Drug Monitoring
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 25
Special Issue Editors
2. Department of Medicine, Surgery and Dentistry, University of Salerno, Fisciano, Italy
Interests: pharmacology; medicinal chemistry; drug monitoring; chromatography; mass spectrometry
2. Department of Medicine, Surgery and Dentistry, University of Salerno, Fisciano, Italy
Interests: laboratory medicine; biochemistry; drug monitoring; chromatography; mass spectrometry
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Special Issue Information
Dear Colleagues,
Recent developments in clinical pharmacology and bioanalytical technology are revolutionizing customized medication treatment. Standardized dosing can often be subtherapeutic or potentially dangerous; this is due to interindividual variability in drug metabolism, distribution, and excretion, which is influenced by genetic, physiological, and pathological variables. Personalized dosing approaches can be developed through therapeutic drug monitoring (TDM) and pharmacokinetic modeling, even for medications with a narrow therapeutic index, such as immunosuppressants, antimicrobials, and antiepileptics. This Special Issue aims to explore the critical roles that TDM and pharmacokinetics play in improving treatment efficacy and reducing toxicity in different patient groups, including pediatric and geriatric patients. We seek studies on novel TDM approaches; the combination of Bayesian predictions and population pharmacokinetics; practical clinical applications; cutting-edge technologies such as microsampling and high-resolution LC-MS/MS platforms; the clinical application of TDM methods; and the practical implications of PK models in real-world clinical settings. This Special Issue particularly focuses on the interplay between pharmacokinetics (PK) and TDM, which are necessary for tailoring drug regimens according to unique patient characteristics. Moreover, it seeks to promote an evidence-based, patient-centered approach for medication personalization.
Dr. Bruno Charlier
Dr. Viviana Izzo
Guest Editors
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Keywords
- therapeutic drug monitoring (TDM)
- pharmacokinetics
- personalized medicine
- LC-MS/MS bioanalysis
- dose individualization
- precision pharmacotherapy
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