Nanoemulsions for Nose-to-Brain Drug Delivery

Dear Colleagues,

This Special Issue focuses on the emerging field of “Nanoemulsions for Nose-to-Brain Drug Delivery” via intranasal administration, targeting enhanced treatment of central nervous system (CNS) disorders. The complex structure of the blood–brain barrier (BBB) presents a significant obstacle in delivering therapeutic agents to the brain. Nanoemulsions, with their submicron droplet size and high surface area, offer a unique means to bypass the BBB by leveraging the olfactory and trigeminal pathways, allowing for direct drug transport from the nasal cavity to the brain. This approach enables both rapid absorption and reduced systemic circulation, optimizing therapeutic outcomes. We invite submissions on innovative formulation techniques, stability studies, pharmacokinetic profiles, and the experimental validation of CNS-targeted nanoemulsions via olfactory and trigeminal routes. Additionally, this Special Issue welcomes insights into the biocompatibility and regulatory challenges of nanoemulsion formulations in neurological applications, alongside interdisciplinary studies bridging pharmaceutical nanotechnology, bioengineering, and neuroscience.

Dr. Clóvis Orlando Pereira Da Fonseca
Dr. Rubiana Mara Mainardes
Guest Editors

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