Advances in Nanoparticle-Based Drug Delivery Systems for Tumor-Targeted Combination Treatment

Dear Colleagues,

In this Special Issue, we will focus on recent advances in tumor-targeted combination therapy strategies based on the design of nano-drug delivery systems. The complexity and heterogeneity of tumors result in critical obstacles that severely impede treatment efficiency, such as the development of multidrug resistance, immunosuppressive tumor microenvironments and narrow therapeutic windows. Therefore, it is impossible to eliminate drug-resistant tumors and prevent cancer metastasis using a single treatment modality. Nanomedicine-mediated combination therapies provide promising approaches to synergistically potentiating the therapeutic efficacy of treatments against malignancies or to exerting superadditive (namely “1 + 1 > 2”) effects that are stronger than those of any monotherapy or their theoretical combinations. Nanotechnology-assisted cooperation among different treatments modalities including chemotherapy, chemodynamic therapy, sonotherapy, radiotherapy, phototherapy, immunotherapy and tumor metabolic reprogramming has been exploited to reverse tumor growth or even to eliminate drug-resistant cancer cells.

This Special Issue aims to publish high-quality research papers and reviews focusing on the design, synthesis, and applications of nanomedicines for tumor multimodal synergistic therapy. Both original research articles and reviews are welcome. Research areas include (but are not limited to) the following topics:

• organic/inorganic nanoparticles;
• stimuli-responsive nanomedicines;
• passive and active targeting;
• programmable drug release;
• chemotherapy;
• chemodynamic therapy;
• sonotherapy;
• radiotherapy;
• photodynamic therapy;
• photothermal therapy;
• immunotherapy;
• tumor metabolic reprogramming.

We look forward to receiving your contributions.

Prof. Dr. Zifu Li
Dr. Xiao Dong
Guest Editors

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