Innovative Drug Delivery Systems: From Nanotechnology to Smart Devices

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 600

Special Issue Editors


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Guest Editor
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
Interests: targetted drug delivery; nanomedicine; formulations; biologics; ingestible devices

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Guest Editor
Department of Health Technology, Danmarks Tekniske Universitet, Lyngby, Denmark
Interests: biomaterials; biofabrication; neural engineering; bone regeneration; drug delivery
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Special Issue Information

Dear Colleagues,

The effective delivery of poorly soluble therapeutic molecules, as well as modern pharmaceutical macromolecules, is a critical challenge. Traditional drug delivery systems often face significant obstacles for these types of drugs, such as inadequate dissolution, rapid degradation, and limited absorption, leading to poor bioavailability. These limitations can reduce the efficacy of drugs and require higher doses that may lead to adverse side effects. The need for more efficient, targeted, and patient-friendly drug delivery approaches has driven research toward innovative technologies that are able to overcome these challenges. Recent advances in drug delivery systems have expanded beyond conventional particles and encapsulation methods. The development of smart nanoformulations, advanced materials, and ingestible devices has opened up new opportunities to enhance drug stability, optimize drug release profiles, and improve bioavailability.

This Special Issue aims to highlight the latest advances in this field, showcasing studies on novel nanoformulations, multifunctional platforms, and smart ingestible devices with controlled drug release profiles. I invite contributions that explore both established and emerging technologies, address key challenges, and provide experimental or theoretical insights into advanced drug delivery systems.

  • Novel Drug Formulations: the development of advanced formulations to enhance drug stability, solubility, and targeted delivery.
  • Smart and Responsive Systems: drug delivery platforms that respond to physiological stimuli (e.g., pH, enzymes, and temperature) for controlled and site-specific release.
  • Drug Release Mechanisms: studies on controlled release kinetics, sustained drug delivery, and the optimization of release profiles.
  • Micro and Nanotechnology: the use of micro and nano devices to improve drug encapsulation, protect against degradation, and enhance membrane permeability.
  • Ingestible Devices: design and characterization of ingestible drug delivery systems, including capsules and microdevices with control capabilities.
  • Fabrication Techniques: advances in microfabrication, 3D printing, and other fabrication technologies for creating complex drug delivery devices.
  • In Vitro and In Vivo Studies: experimental evaluation of novel drug delivery systems, including their pharmacokinetics, pharmacodynamics, and biocompatibility.

I look forward to receiving your contributions.

Dr. Mahdi Ghavami
Dr. Zhongyang Zhang
Guest Editors

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Keywords

  • smart nanoparticles
  • innovative drug delivery
  • ingestible devices
  • targeted delivery systems
  • controlled release
  • microfabrication techniques
  • nano and microtechnology
  • biocompatible materials
  • bioavailability

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Published Papers (1 paper)

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Research

31 pages, 6969 KiB  
Article
A Green, Solvent- and Cation-Free Approach for Preparing 5-Fluorouracil-Loaded Alginate Nanoparticles Using Microfluidic Technology
by Abdolelah Jaradat, Ali Alazzo, Mohammad F. Bayan and Wasfy Obeidat
Pharmaceutics 2025, 17(4), 438; https://doi.org/10.3390/pharmaceutics17040438 - 29 Mar 2025
Viewed by 326
Abstract
Background/Objectives: Alginate nanoparticles (NPs) are commonly synthesised using either an emulsion technique that involves organic solvent use or ionotropic gelation utilising multivalent cations, e.g., Ca+2. However, the extensive use of organic solvents imposes detrimental effects on the ecosystem, and using [...] Read more.
Background/Objectives: Alginate nanoparticles (NPs) are commonly synthesised using either an emulsion technique that involves organic solvent use or ionotropic gelation utilising multivalent cations, e.g., Ca+2. However, the extensive use of organic solvents imposes detrimental effects on the ecosystem, and using multivalent cations as crosslinkers could eventually lead to the leakage of these cations, thus disrupting nanoparticle matrices. Therefore, this study aimed to overcome the limitations of these techniques by eliminating the usage of organic solvents and multivalent cations. Methods: In this research, alginate nanoparticles were synthesised using proton gelation by microfluidic technology through protonating alginate carboxylate groups to crosslink alginate chains through H-bond formation. Results: The prepared acid-gelled alginate nanoparticles demonstrated an MHD circa 200 nm and a PDI of less than 0.4 at pH 0.75. Moreover, 5-FU was successfully encapsulated into acid-gelled alginate nanoparticles and displayed a high EE% of around 30%, comparable to the EE% at high alginate concentration and molecular weight (0.4 H-ALG) achieved by Ca+2-crosslinked alginate nanoparticles; however, 5-FU NPs had superior characteristics, i.e., a lower MHD (around 500 nm) and PDI (<0.5). The optimum formula (0.4 H-ALG) was explored at various pH values, i.e., low pH of 4.5 and high pH of 10, and alginate NPs produced by acid gelation demonstrated high stability in terms of MHD and PDI, with slight changes at different pH values, indicating stable crosslinking of alginate matrices prepared by technology compared with Ca+2-crosslinked alginate NPs. Conclusions: In conclusion, this research has invented an ecologically friendly approach to producing acid-gelled alginate nanoparticles with superior characteristics compared with the conventional methods, and they could be harnessed as nanocarriers for therapeutics delivery (5-FU). Also, this research offers a promising approach for developing eco-friendly and biocompatible drug carriers. The produced nanoparticles have the potential to enhance drug stability, improve controlled release, and minimise toxic effects, making them suitable for pharmaceutical applications. Full article
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