Special Issue "Advanced Characterization of Inhalation Medicinal Products"
Deadline for manuscript submissions: closed (31 December 2020).
Interests: pharmaceutical nanotechnology; nasal delivery; brain delivery; lung cancer; polysaccharides
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Special Issue in Molecules: Advances on Pharmaceutical Nanotechnology at the Interface with Biological Barriers
Pulmonary drug delivery over the past twenty years has been demonstrated not only to be a valuable approach to treat a number of local diseases such as infections, asthma, and COPD but has shown great potential for drug delivery systemically thanks to its high surface area and the absorptive potential of the respiratory region of the lungs. This has presented the possibility to develop new and promising products for the delivery of small molecules, as well as peptide and proteins, for the treatment of clinically relevant diseases such as diabetes. However, the look for new therapeutic approaches has led to lead compounds that in comparison to those in the clinical use present some challenges such as lower aqueous solubility; poor permeability; and high dosages sometimes combined with challenging solid state properties impacting aerosol performances such as cohesiveness, hygroscopicity, and poor flowability. On the other side, more complex formulations are proposed, in some cases in view of providing a controlled release of drugs after lung deposition. In this scenario, the classic pharmacopoeial tests for inhalation products do not appear to be the set of tools appropriate to investigate and characterize such new products.
The aim of this Special Issue is to showcase a series of advanced approaches for the characterization of innovative products for pulmonary delivery, with special emphasis on issues related to aerosol performance, physico-chemical characterisation, dissolution studies, particle engineering, controlled release formulations, and the behavior of the product at biological interfaces. As Guest Editors, we cordially invite you to contribute a research paper or comprehensive review on any aspect related to this topic.
Prof. Dr. Fabio Sonvico
Prof. Dr. Francesca Buttini
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Pulmonary delivery
- Dry powders inhalers
- In vitro models of airways epithelia
- Dissolution studies
- Solid state characterization
- Aerosol performance.