The Development of Drug Delivery Systems and Pharmaceutical Formulations for the Treatment of Infectious Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 512

Special Issue Editors


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Guest Editor
Instituto de Investigaciones para la Industria Química, Universidad Nacional de Salta—Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Bolivia 5150, Salta 4400, Argentina
Interests: drug delivery systems; modified drug release; neglected infectious diseases; mathematical modeling

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Guest Editor
1. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA-CONICET), Haya de la Torre y Medina Allende, Córdoba X5000XHUA, Argentina
2.Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Córdoba X5000XHUA, Argentina
Interests: materials chemistry; nanotechnology; surfactants; solid dispersion; formulations; rheology; nanoparticles; vaccines; nanomaterials; gels

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the development of innovative drug delivery systems (DDSs) and pharmaceutical formulations to optimize the treatment of infectious diseases, with an emphasis on bacterial, viral, and parasitic infections. It highlights advanced DDS technologies, including polymer-based systems, nanocarriers, and emerging platforms, aimed at enhancing therapeutic efficacy, stability, and targeted drug delivery. Particular attention is given to the application of polymers in formulations designed for controlled, sustained, or targeted release, addressing challenges posed by multidrug-resistant pathogens and difficult-to-treat infections. This Special Issue also explores cutting-edge advances in nanoformulations, liposomal carriers, and biocompatible materials that improve drug penetration, reduce toxicity, and enable site-specific delivery. By bringing together the latest research, this Special Issue underscores the potential of these technologies to tackle the growing challenges of infectious diseases, enhance clinical outcomes, and combat emerging threats, including parasitic infections.

Dr. José María Bermúdez
Prof. Dr. Santiago Daniel Palma
Guest Editors

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Keywords

  • drug delivery systems
  • pharmaceutical formulations
  • nanoformulations
  • parasitic infections
  • controlled drug release

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Published Papers (1 paper)

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Research

19 pages, 2810 KiB  
Article
In Vitro Assessment of a Doubly Adjuvanted Self-Emulsified Nanoemulsion as a Delivery Vehicle for Antigenic Proteins
by Evgenia Tsanaktsidou, Maritsa Margaroni, Evdokia Karagouni, Costas Kiparissides and Olga Kammona
Pharmaceutics 2025, 17(7), 870; https://doi.org/10.3390/pharmaceutics17070870 - 2 Jul 2025
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Abstract
Background/Objectives: Leishmaniasis is a prevailing infectious disease transmitted via infected phlebotomine sandflies. The lack of an efficient vaccine with respect to immunogenic antigens and adjuvanted delivery systems impedes its control. Following the induction of immune responses in mice vaccinated with multi-epitope Leishmania peptides [...] Read more.
Background/Objectives: Leishmaniasis is a prevailing infectious disease transmitted via infected phlebotomine sandflies. The lack of an efficient vaccine with respect to immunogenic antigens and adjuvanted delivery systems impedes its control. Following the induction of immune responses in mice vaccinated with multi-epitope Leishmania peptides (LeishPts) encapsulated in doubly adjuvanted self-nanoemulsifying drug delivery systems (ST-SNEDDSs), this study aims to assess ST-SNEDDS-based nanoemulsions as vehicles for the delivery of antigenic proteins. Methods: Model antigens (e.g., BSA-FITC, OVA) were encapsulated in ST-SNEDDS after being complexed with the cationic phospholipid dimyristoyl phosphatidylglycerol (DMPG) via hydrophobic ion pairing. The nanoemulsions were characterized with respect to droplet diameter, zeta potential, stability, protein loading, protein release from the nanodroplets in different release media and cell uptake. Results: Both model antigens exhibited high encapsulation efficiency (>95%) and their release from the nanodroplets was shown to be strongly affected by the type of release medium (e.g., PBS, FBS 10% v/v) and the ratio of its volume to that of the oily phase, in agreement with predictions of protein release. Protein-loaded nanoemulsion droplets labeled with Cy-5 were found to be efficiently taken up by macrophages (J774A.1) in vitro. However, no colocalization of the labeled nanodroplets and BSA-FITC could be observed. Conclusions: It was revealed that in contrast with LeishPts, whole protein molecules may not be appropriate antigenic cargo for ST-SNEDDS formulations due to the rapid protein release from the nanodroplets in release media simulating in vitro culture and in vivo conditions such as FBS 10% v/v. Full article
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