Nanoparticle-Based mRNA Vaccines

Dear Colleagues,

mRNA vaccines have revolutionized the field by enabling rapid and precise immune responses against infectious diseases and cancers. However, their inherent instability and vulnerability to degradation pose significant challenges in ensuring their efficient and targeted delivery. Nanotechnology offers innovative solutions that overcome these barriers and enhance the efficacy of mRNA vaccines. Additionally, rationally designed mRNA sequences can improve molecular stability and extend the expression of desired antigens. By combining advancements in nanoparticle technology with insights from mRNA structural biology, researchers can create a modular framework for developing next-generation mRNA-based vaccines.

This Special Issue, titled “Nanoparticle-Based mRNA Vaccines”, aims to highlight the convergence of cutting-edge materials science and mRNA engineering to advance the therapeutic potential of mRNA vaccines. We welcome submissions of original research, communications, and review articles addressing topics such as mRNA’s structural optimization, novel nanomaterials, the formulation and manufacturing of nanoparticles, mRNA-related immunogenicity, and artificial intelligence-guided vaccine design.

Dr. Yunlu Dai
Dr. Yonger Xue
Dr. Zhiwei Fang
Guest Editors

Manuscript Submission Information

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