Current Research in Drug Metabolism and Drug–Drug Interactions (DDIs)

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 1724

Special Issue Editor


E-Mail Website
Guest Editor
Department of Pharmaceutical Chemistry, Semmelweis University, 1085 Budapest, Hungary
Interests: in vitro early ADME models; CNS and ophthalmic drug permeability; eye drop formulas; drug metabolism; rheology-mucoadhesivity correlation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

One of the most complex pharmacokinetic characteristics of drug research that covers the entire process is drug metabolism and the associated drug–drug interactions (DDIs). A repeated summary of the new research and development of the field is highly justified and helps the scientific community to identify new problems and outline possible solutions.

In accordance with the above, the Special Issue entitled “Current Research in Drug Metabolism and Drug-Drug Interactions (DDIs)” will consider for publication manuscripts describing the results of original basic and clinical research that contribute significant and novel information on the following topics:

  • The metabolic studies of important existing drugs or known toxicants that address their potential clinical or translational significance;
  • Novel in vivo, in vitro, ex vivo, or in silico model systems for drug metabolism and DDIs, such as 3-D culture, stem cells, and liver-on-a-chip systems;
  • Novel analytical technologies and toolboxes that can be broadly applied to the study of drug metabolism and DDIs;
  • The mechanistic aspects of drug metabolism and DDIs, including the structural studies of formed (reactive) metabolites, enzymes, and transporters and the biochemical studies of nuclear receptors that regulate drug metabolism;
  • The impact of drug metabolism on pharmacokinetics, pharmacodynamics, or drug adverse effects, such as DDIs;
  • The studies of drug metabolism by microbiome or other non-animal species offer new insights into the biological fate of drugs or other xenobiotics in living systems.

I look forward to receiving your contributions.

Prof. Dr. György T. Balogh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmacokinetic
  • drug metabolism
  • drug–drug interactions (DDIs)
  • pharmacodynamics
  • drug adverse
  • in vivo
  • in vitro
  • stem cells
  • liver-on-a-chip

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

10 pages, 3427 KiB  
Article
High-Throughput Drug Stability Assessment via Biomimetic Metalloporphyrin-Catalyzed Reactions Using Laser-Assisted Rapid Evaporative Ionization Mass Spectrometry (LA-REIMS)
by András Marton, Zsombor Mohácsi, Balázs Decsi, Balázs Csillag, Júlia Balog, Richard Schäffer, Tamás Karancsi and György Tibor Balogh
Pharmaceutics 2024, 16(10), 1266; https://doi.org/10.3390/pharmaceutics16101266 - 27 Sep 2024
Cited by 1 | Viewed by 1123
Abstract
Background: Building extensive drug candidate libraries as early in the development pipeline as possible, with high-throughput in vitro absorption, distribution, metabolism, and excretion (ADME) profiling, is crucial for the selection of lead compounds to guide subsequent research and production phases. Traditionally, the analysis [...] Read more.
Background: Building extensive drug candidate libraries as early in the development pipeline as possible, with high-throughput in vitro absorption, distribution, metabolism, and excretion (ADME) profiling, is crucial for the selection of lead compounds to guide subsequent research and production phases. Traditionally, the analysis of metabolic stability assays heavily relies on high-throughput LC-MS/MS (liquid chromatography tandem mass spectrometry) techniques to meet with the lead profiling demands. Laser-assisted rapid evaporative ionization mass spectrometry (LA-REIMS) is a quick and efficient technique for characterizing complex biological samples without laborious sample preparation. Objective: In this study, using an automated LA-REIMS well plate reader, achieving an 8 s per sample measurement time, the oxidative metabolic stability of active drug agents was assessed using biomimetic metalloporphyrin-based oxidative model reactions. Results: The results obtained using the novel LA-REIMS-based protocol were compared to and corroborated by those obtained using conventional HPLC-UV-MS (high performance liquid chromatography with ultra-violet detection coupled with mass spectrometry) measurements. Conclusions: LA-REIMS emerges as a promising technique, demonstrating potential suitability for semi-quantitative high-throughput metabolic stability in an optimized solvent environment. Full article
Show Figures

Graphical abstract

Back to TopTop