Advanced Research on Transdermal Drug Delivery
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 20
Special Issue Editors
Interests: transdermal drug delivery; dissolving microneedles; nano-microparticulate drug delivery
Special Issues, Collections and Topics in MDPI journals
Interests: transdermal drug delivery; dissolving microneedles; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Interests: microneedles; pulmonary drug delivery; novel drug-delivery systems
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Skin, the largest organ in the human body, offers several advantages over other routes of drug administration. Transdermal drug delivery can circumvent the gastrointestinal and hepatic first-pass effect, ensuring consistent and predictable drug concentrations in the blood. This method of delivery is also convenient, providing a simple and hassle-free means by which to administer medication. Notably, it has the unique benefit of reducing toxic side effects and enhancing compliance, making it a highly appealing option for patients and healthcare providers. In comparison with those in other mucous membranes, the protein hydrolysis enzymes in skin tissue are present in comparatively low concentrations. This property is conducive to maintaining the stability of macromolecular drugs. However, the skin stratum corneum functions as a barrier for the organism against external aggression and also as a barrier to the entry of active ingredients into the body, thereby limiting the transdermal delivery of most drugs, especially macromolecular drugs. Over the past few decades, various systems have been developed for the transdermal delivery of different therapeutic agents, including small molecules, biological macromolecules, vaccines, and even nanoparticles.
This Special Issue addresses the design, preparation, and characterization of transdermal drug delivery systems, including microneedles, patches, hydrogels, and creams, among others, and their use in strategies for the prevention or treatment of medical conditions such as cancer, infection, diabetes, vaccination, and dermatological diseases.
Dr. Tingting Peng
Dr. Guilan Quan
Dr. Xin Pan
Guest Editors
Manuscript Submission Information
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Keywords
- transdermal drug delivery
- skin drug delivery
- percutaneous drug delivery
- topical drug delivery
- microneedles
- patches
- hydrogels
- creams
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